Abstract
Ion-selective sensors based on organic ion exchangers of the ampicillin (oxacillin)-tetradecylammonium (Am-TDA; Ox-TDA) type sensitive to antibiotics of the penicillin group have been developed. The ratio of components (1: 1) and the solubility products of ion associates (8.5 × 10−8 and 5.2 × 10−10 for Am-TDAand Ox-TDA, respectively) are determined. According to thermoanalytical data, both Am-TDAand Ox-TDAion associates are individual substances not containing water. The organic ion exchangers do not undergo changes on heating up to 70°C. It is established that the electrode functions are linear in the interval from 1 × 10 −5 to 1 × 10−1 M for all antibiotics studied. The slopes of the electrode functions for Am and Ox are 58 × 1 and 60 × 1, respectively, being close to the theoretical values for singly charged ions. Methods for the determination of Am and Ox in the blood serum and saliva and in various medicinal forms (tablets, powders in bottles, etc.) are described.
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References
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 53–55, March, 2006.
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Kulapina, E.G., Baraguzina, V.V. & Kulapina, O.I. Ion-selective sensors for determining ampicillin and oxacillin in biological fluids and pharmaceuticals. Pharm Chem J 40, 171–174 (2006). https://doi.org/10.1007/s11094-006-0084-9
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DOI: https://doi.org/10.1007/s11094-006-0084-9