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Adaptation of Staphylococcus aureus to synthetic triazolides

  • Medicinal Plants
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Abstract

The ability of Staphylococcus aureus to adapt to the toxic action of 1,2,4-triazole and its sulfuryl derivates has been studied. A positive correlation is found between the lipophilicity and toxicity of substances. It is established that methylated derivates are more toxic than substances without methyl radicals. St. aureus species grown on a medium containing triazolides in a nontoxic dose become resistant to highly toxic doses of these substances. The possible mechanisms of St. aureus adaptation to triazolides are discussed.

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References

  1. T. Alarcon, J. C. Sanz, F. Blanco, et al, Eur. J. Clin. Pharmacol., 17, 877–879 (1998).

    CAS  Google Scholar 

  2. W. Witte, M. Kresken, C. Braulke, and C. Cuny, Clin. Microbiol. Infect., 3, 414–422 (1997).

    Article  PubMed  Google Scholar 

  3. M. D. Mashkovskii, Drugs [in Russian], Gamta, Vilnius (1994), Vols. 1–2.

    Google Scholar 

  4. Dangerous Substances in Industry. Vol. 1: Organic Compounds [in Russian], N. B. Lazarev (ed.), Khimiya, Moscow (1971), p. 831.

    Google Scholar 

  5. Hygienic Criteria of Environment (64): Carbamate Pesticides, WHO, Geneve (1991), p. 126.

  6. G. M. Barenboim and A. G. Malenkov, Biologically Active Substances: New Principles of Research [in Russian], Nauka, Moscow (1986), p. 363.

    Google Scholar 

  7. A. M. Amosova, E. S. Selezneva, Z. P. Belousova, and E. I. Ten’gaev, in: Nitrogen-Containing Heterocycles: Synthesis, Properties, and Applications (A Collection of Scientific Papers) [in Russian], Astrakhan (2000), pp. 99–100.

  8. E. S. Selezneva, Z. P. Belousova, E. I. Ten’gaev, et al., Khim.-Farm. Zh., 37(8), 14–17 (2003).

    Google Scholar 

  9. S. V. Ivont’eva, E. S. Selezneva, and Z. P. Belousova, Abstracts of Papers. Symp. “Safety of the Biosphere” [in Russian], Yekaterinburg (1999). pp. 154.

  10. P. P. Purygin, I. A. Poletaeva, Z. P. Belousova, et al., Khim.-Farm. Zh., 36(1), 16–17 (2002).

    CAS  Google Scholar 

  11. L. Birkofer, W. Gildenberg, and A. Ritter, Angew. Chem., 73, 143 (1961).

    CAS  Google Scholar 

  12. Z. P. Belousova and E. S. Selezneva, in: Chemistry for Medicine and Veterinary (A Collection of Scientific Papers) [in Russian], Saratov State University (1998), pp. 21–23.

  13. Methodological Instructions on Determining the Drug Sensitivity of Microbes by the Method of Diffusion into Agar from Impregnated Disks [in Russian], Ministry of Public Health, Moscow (1983), p. 16.

  14. C. Auerbach, Mutation Research, Chapman & Hall, London (1976).

    Google Scholar 

  15. Kh. D. Yuldashev, A.D. Dzhuraev, A.G. Maksudin, and N. A. Amatov, Khim.-Farm. Zh., 26(1), 57–70 (1992).

    Google Scholar 

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Authors and Affiliations

  1. Samara State University, Samara, Russia

    E. S. Selezneva, Z. P. Belousova, A. I. Ivanchina & E. I. Ten’gaev

Authors
  1. E. S. Selezneva
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  2. Z. P. Belousova
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  3. A. I. Ivanchina
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  4. E. I. Ten’gaev
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 27–29, March, 2006.

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Selezneva, E.S., Belousova, Z.P., Ivanchina, A.I. et al. Adaptation of Staphylococcus aureus to synthetic triazolides. Pharm Chem J 40, 145–148 (2006). https://doi.org/10.1007/s11094-006-0079-6

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  • DOI: https://doi.org/10.1007/s11094-006-0079-6

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