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Synthesis of 1-alkyl-3,4-dihydroisoquinoline derivatives and study of their effect on arterial pressure

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Abstract

A series of 1-alkyl-3,4-dihydroisoquinolines and the related 4-alkyl-1,2-dihydro-benzo[f]isoquinolines was synthesized using reactions of dialkylbenzylcarbinols and their naphthyl analogs with alkylcyanides. Experiments showed that 1-alkyl-6,7-dimethoxy-3,4-dihydroisoquinolines typically produce a hypotensive action, while the benzo-annelated structures usually exhibit a hypertensive effects. The most active compound decreases the arterial pressure in cats by 52 Torr and the effect lasts for about 4 hours.

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References

  1. A. G. Mikhailovskii, B. Ya. Syropyatov, V. S. Shklyaev, et al., Khim.-Farm. Zh., 32(8), 21–23 (1998).

    CAS  Google Scholar 

  2. A. G. Mikhailovskii, Yu. N. Bubnov, B. Ya. Syropyatov, et al., Khim.-Farm. Zh., 33(3), 15–18 (1999).

    Google Scholar 

  3. A. G. Mikhailovskii, A. V. Dolzhenko, B. Ya. Syropyatov, et al., Khim.-Farm. Zh., 36(6), 8–10 (2002).

    Google Scholar 

  4. A. G. Mikhailovskii, B. Ya. Syropyatov, A. V. Dolzhenko, and M. I. Vakhrin, Khim.-Farm. Zh., 36(7), 33–35 (2002).

    Google Scholar 

  5. N. N. Polygalova, B. Ya. Syropyatov, A. G. Mikhailovskii, et al., Abstracts of Papers. The 9th All-Russian Congr. “Humans and Drugs” [in Russian], Moscow (2004), p. 565.

  6. B. B. Aleksandrov, V. S. Shklyaev, and Yu. V. Shklyaev, Khim. Geterotsikl. Soedin., No. 3, 373–376 (1992).

  7. R. Z. Dautova, V. S. Shklyaev, B. Ya. Syropyatov, et al., Khim.-Farm. Zh., 23(2), 172–176 (1989).

    CAS  Google Scholar 

  8. V. P. Berezina, N. E. Vasilevskaya, M. S. Averbakh, et al., A Big Practical Guide in Human and Animal Physiology [in Russian], Vysshsya Shkola, Moscow (1961), pp. 162_–167.

    Google Scholar 

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    N. N. Polygalova, A. G. Mikhailovskii, E. S. Limanskii, B. Ya. Syropyatov & M. I. Vakhrin

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  1. N. N. Polygalova
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  2. A. G. Mikhailovskii
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  3. E. S. Limanskii
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  4. B. Ya. Syropyatov
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  5. M. I. Vakhrin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 15–17, March, 2006.

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Polygalova, N.N., Mikhailovskii, A.G., Limanskii, E.S. et al. Synthesis of 1-alkyl-3,4-dihydroisoquinoline derivatives and study of their effect on arterial pressure. Pharm Chem J 40, 132–134 (2006). https://doi.org/10.1007/s11094-006-0076-9

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  • DOI: https://doi.org/10.1007/s11094-006-0076-9

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