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Synthetic analogs of phytanic acid and their effect on human hepatic cholesterol esterase in vitro

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Abstract

Ten acyclic isoprenoid fatty acids were synthesized and tested in vitro as possible regulators of the cholesterol/cholesteryl alkanoate ratio in blood serum lipoproteins. Racemic C20 analogs of (3R/S,7R, 11R)-3,7,11,15-tetramethylhexadecanoic (phytanic) acid proved to be powerful activators of human liver cholesterol esterase (HLCE) in vitro. Achiral (E,E)-5,9,13-trimethyltetradeca-4,8,12-trienoic (farnesylacetic) acid, a low-toxicity antiulcerative substance, also significantly accelerates the HLCE-catalyzed hydrolysis of cholesteryl palmitate.

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Authors and Affiliations

  1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

    É. P. Serebryakov, G. V. Kryshtal’, G. M. Zhdankina & A. G. Nigmatov

  2. Institute of Experimental Cardiology, Russian Cardiological Scientific and Practical Center, Ministry of Public Health, Moscow, Russia

    V. V. Tertov & L. V. Filatova

Authors
  1. É. P. Serebryakov
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  2. G. V. Kryshtal’
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  3. G. M. Zhdankina
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  4. A. G. Nigmatov
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  5. V. V. Tertov
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  6. L. V. Filatova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 1, pp. 23–28, January, 2006.

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Serebryakov, É.P., Kryshtal’, G.V., Zhdankina, G.M. et al. Synthetic analogs of phytanic acid and their effect on human hepatic cholesterol esterase in vitro . Pharm Chem J 40, 23–28 (2006). https://doi.org/10.1007/s11094-006-0050-6

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  • DOI: https://doi.org/10.1007/s11094-006-0050-6

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