Abstract
A series of substituted 2-amino-3-ethoxycarbonylpyrazines containing indole, resorcinol, thiophenol, ethyl cyanoacetate, indandione, and antipyrine moieties was obtained via reactions of nucleophilic substitution of hydrogen in the initial 2-aminopyrazine-1-oxides. Some of the synthesized compounds inhibit the reproduction of measles viruses and exhibit a weak antiviral activity with respect to Marburg virus. However, most of the new substituted pyrazines are not cytotoxic and exhibit no activity against ortho-poxviruses and measles viruses.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 12–16, December, 2005.
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Rusinov, V.L., Kovalev, I.S., Kozhevnikov, D.N. et al. Synthesis and antiviral activity of 2-amino-3-ethoxycarbonylpyrazine derivatives. Pharm Chem J 39, 630–635 (2005). https://doi.org/10.1007/s11094-006-0034-6
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DOI: https://doi.org/10.1007/s11094-006-0034-6