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The role of major apoptotic proteins in Ca2+ dependent cell homeostasis

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

Abstract

The key role of Bcl-2 (B-cell lymphoma) family proteins in programmed cell death (apoptosis) is reliably established, but particular molecular mechanisms of downregulation involving these anti-and pro-apoptotic proteins are still insufficiently clear. There are several hypotheses explaining the cell-protective (Bcl-2, Bcl-XL) and pro-apoptotic (Bcl-x, Bak) functions of Bcl-2 family proteins. This paper briefly summarizes the available information concerning the molecular mechanisms of action of the pro-and anti-apoptotic proteins of Bcl-2 family. In particular, an original hypothesis is put forward according to which homo-and heterodimerization of these proteins are the key events in the mechanism of Ca2+ ion dependent homeostasis regulation.

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Authors and Affiliations

  1. Hematological Research Center, Russian Academy of Medical Sciences, Moscow, 124167, Russia

    E. V. Orlova & V. P. Panov

  2. Shemyakin — Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia

    I. A. Kostanyan

Authors
  1. E. V. Orlova
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  2. I. A. Kostanyan
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  3. V. P. Panov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 3–8, December, 2005.

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Orlova, E.V., Kostanyan, I.A. & Panov, V.P. The role of major apoptotic proteins in Ca2+ dependent cell homeostasis. Pharm Chem J 39, 621–626 (2005). https://doi.org/10.1007/s11094-006-0032-8

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  • DOI: https://doi.org/10.1007/s11094-006-0032-8

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