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Pharmaceutical Chemistry Journal

, Volume 39, Issue 7, pp 358–360 | Cite as

Investigation of the Gestagen Activity of 17α-acetoxy-3β-butanoyloxy-6-methylpregna-4,6-dien-20-one

  • P. V. Sergeev
  • V. M. Rzheznikov
  • V. V. Korkhov
  • G. S. Grinenko
  • A. V. Semeikin
  • E. E. Mayatskaya
  • R. V. Samoilikov
  • N. L. Shimanovskii
Article

Abstract

The gestagen activity of a new synthetic progesterone derivative, 17α-acetoxy-3β-butanoiloxy-6-methylpregna-4,6-dien-20-one (ABMP) has been studied in rabbits (Clauberg - McPhail test) and in rats (test for the ABMP influence on the progesterone level in blood and on the endometrium morphology). The gestagen activity of ABMP is more pronounced than that of reference drugs (progesterone, levonorgestrel, acetomepregenol). ABMP transforms the endometrium of experimental animals from proliferative to secretory phase and reduces mitotic activity of endometrium in rats. ABMP reduces progesterone level in the rat blood to a lower degree than do the reference drugs. ABMP exhibits no anabolic and androgenic activity in the Hershberger test in rats.

Keywords

Organic Chemistry Experimental Animal Progesterone Lower Degree Mitotic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • P. V. Sergeev
    • 1
  • V. M. Rzheznikov
    • 2
  • V. V. Korkhov
    • 3
  • G. S. Grinenko
    • 3
  • A. V. Semeikin
    • 1
  • E. E. Mayatskaya
    • 1
  • R. V. Samoilikov
    • 1
  • N. L. Shimanovskii
    • 1
  1. 1.State Medical UniversityMoscowRussia
  2. 2.Scientific Endocrinological CenterRussian Academy of Medical SciencesMoscowRussia
  3. 3.Center for Drug ChemistryAll-Russia Research Institute of Pharmaceutical ChemistryMoscowRussia

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