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Methods of Evaluation of the Antimicrobial Activity of Medicinal Preparations

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
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Pharmaceutical Chemistry Journal Aims and scope

Abstract

Methods of evaluation of the antimicrobial activity of nonsterile medicinal preparations are considered. A modified method according to the State Pharmacopoeia (XIth Ed.) is compared to an alternative replication technique applicable to water-insoluble products and also to fatty and colored preparations. The replication method has the advantage of being economical (use of only two culture media), fast (24 – 72 h), and universal (admitting the use of a broad set of test microbes). The final choice of the method depends primarily on the nature of each particular preparation.

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REFERENCES

  1. USSR State Pharmacopoeia, XIth Edition [in Russian], Moscow (1990), Vol. 2, pp. 193–200.

  2. Pharmacopoeia of Czechoslovakian Republic, 4th Edition [in Czech], Praha (1987).

  3. United States Pharmacopoeia, 21st Edition, Rockville (1985).

  4. Methods for Microbiological Control of Medicinal Preparations. Modification No. 2 of the General Clause of the State Pharmacopoeia, XI Edition [in Russian], Moscow (2001).

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Authors and Affiliations

  1. Institute for State Control of Drugs, State Scientific Center for Drug Expertise and Control, Ministry of Public Health of the Russian Federation, Moscow, Russia

    O. V. Gunar & K. A. Kagramanova

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  1. O. V. Gunar
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  2. K. A. Kagramanova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 5, pp. 53 – 56, May, 2005.

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Gunar, O.V., Kagramanova, K.A. Methods of Evaluation of the Antimicrobial Activity of Medicinal Preparations. Pharm Chem J 39, 278–282 (2005). https://doi.org/10.1007/s11094-005-0132-x

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  • DOI: https://doi.org/10.1007/s11094-005-0132-x

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