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Synthesis and Antimycobacterial Activity of Triazene Derivatives of N-Arylcarbamates

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Abstract

A series of new triazene derivatives of N-arylcarbamates was synthesized via condensation of equimolar amounts of alkyl-N-(4-nitrosophenyl)carbamates with substituted hydrazines in ethanol. The antimycobacterial activity of the synthesized compounds was studied in vitro on cell cultures of Micobacterium tuberculosis and Micobacterium lufu. The reference drugs were isoniazid and dapsone. The chemical modification of isonicotinic acid hydrazide with the formation of triazene derivatives of N-arylcarbamates does not lead to a significant decrease in their antimycobacterial activity.

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Authors and Affiliations

  1. Astrakhan State University, Astrakhan, Russia

    A. V. Velikorodov

  2. Leprosy Research Institute, Astrakhan, Russia

    N. G. Urlyapova & A. D. Daudova

Authors
  1. A. V. Velikorodov
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  2. N. G. Urlyapova
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  3. A. D. Daudova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 3, pp. 16 – 17, March, 2005.

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Velikorodov, A.V., Urlyapova, N.G. & Daudova, A.D. Synthesis and Antimycobacterial Activity of Triazene Derivatives of N-Arylcarbamates. Pharm Chem J 39, 126–128 (2005). https://doi.org/10.1007/s11094-005-0099-7

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  • DOI: https://doi.org/10.1007/s11094-005-0099-7

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