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Cytotoxic and Antitumor Activity of Antimony(III) Nitrilotriacetate Complexes M2SB(Nta)(HNta) · nH2O (M = NH4, Na; n = 1, 2)

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Abstract

Antimony(III) nitrilotriacetate complexes with mixed Nta3− and HNta2− ligands of composition (NH4)2Sb(Nta)(HNta) · nH2O (I) and Na2Sb(Nta)(HNta) · 2H2O (II) were synthesized. The proposed structures were confirmed by chemical analysis, x-ray diffraction, IR spectroscopy, and thermogravimetry. The cytotoxic properties of antimony chelates in vitro and their antitumor activity with respect to Ehrlich adenocarcinoma (EAC) in mice were studied. Compounds I and II produced a significant (60 – 90%) increase in the survival rate of test mice with ascitic EAC, at an optimum therapeutic dose of 25 – 50 mg/kg, in the absence of significant toxicity in this dose range. The results show good prospects in the search for new antitumor agents among Sb(III) complexes with aminopolycarboxy ligands.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-East Division, Russian Academy of Sciences, Vladivostok, Russia

    A. M. Popov, I. A. Li & A. V. Skul’beda

  2. Institute of Chemistry, Far-East Division, Russian Academy of Sciences, Vladivostok, Russia

    R. L. Davidovich

  3. Department of Chemistry, Xiamen University, Xiamen, China

    S.-Z. Hu

Authors
  1. A. M. Popov
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  2. R. L. Davidovich
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  3. I. A. Li
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  4. A. V. Skul’beda
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  5. S.-Z. Hu
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 3, pp.9 – 11, March, 2005.

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Popov, A.M., Davidovich, R.L., Li, I.A. et al. Cytotoxic and Antitumor Activity of Antimony(III) Nitrilotriacetate Complexes M2SB(Nta)(HNta) · nH2O (M = NH4, Na; n = 1, 2). Pharm Chem J 39, 119–121 (2005). https://doi.org/10.1007/s11094-005-0097-9

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  • DOI: https://doi.org/10.1007/s11094-005-0097-9

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