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Amination of Cyclohexane by Dielectric Barrier Discharge Processing in a Continuous Flow Microreactor: Experimental and Simulation Studies


A miniaturized flow device has been developed to combine microfluidics technology and plasma process. In this microreactor, atmospheric pressure dielectric barrier discharges are generated in a gas in contact with a liquid phase. This study was conducted with plasma generated in ammonia in contact with a flow of liquid cyclohexane. Cyclohexylamine was synthesized with a good selectivity, and the process can be implemented to improve conversion and effectiveness. Numerical simulations confirmed that NH2 radicals are generated in the plasma and react with cyclohexyls radicals to achieve the reaction, giving a selectivity of 50% and a total molar conversion of 20% of cyclohexane. The effects of voltage and frequency on the selectivity and the experimental conversion rate were studied and discussed.

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This work has received the support of Institut Pierre-Gilles de Gennes (laboratoire d’excellence, “Investissements d’avenir” program ANR-10-EQPX-34, program ANR-10-IDEX-0001-02 PSL and ANR-10-LABX-31.).


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Correspondence to Stéphanie Ognier.

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Lepoetre, A., Ognier, S., Zhang, M. et al. Amination of Cyclohexane by Dielectric Barrier Discharge Processing in a Continuous Flow Microreactor: Experimental and Simulation Studies. Plasma Chem Plasma Process 41, 351–368 (2021).

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  • Amination
  • Ammonia discharges
  • Dielectric barrier discharges (DBD)
  • Microreactor
  • Radicals
  • Flow chemistry