Abstract
In this study, a photonic crystal lattice structure consisting of a Gallium Arsenide composite semi-conductive material with an air background is employed to identify the presence of cancer in red blood cells (RBCs). The five types of cancer being analyzed are breast, basal, cervical, blood, and adrenal gland cancer. The proposed structure's optical and dispersion characteristics are investigated using plane wave expansion and finite difference time domain methods. The proposed structure distinguishes between healthy RBCs and cancer-infected cells by varying the refractive index. The proposed biosensor has a high sensitivity of 1013.2 nm/RIU, a Q-factor of 11,909.199, a low detection limit of 1.647 × 10–4 RIU, a high FOM of 6068.416 RIU−1, an amplitude sensitivity of 9.343 a.u./RIU, and a compact area of 51.66 µm2. Using the proposed structure, it is possible to create a label-free biosensing environment. This device is beneficial in biological applications, such as early cancer diagnosis. As a consequence, overall healthcare system quality has improved.
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This work is supported by the All India Council for Technical Education (AICTE) for financial assistance as JRF/SRF to Manjunatha N (S202173) under the AICTE Doctoral Fellowship (ADF) scheme.
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Mr. Manjunatha N contributes to conceptualization, methodology, writing original draft, and visualization. Dr. Sarika Raga contributes to resources, supervision, review, and editing. Dr. Sanjay Kumar Gowre contributes to conceptualization, supervision, review, and editing. Mr. Hameed Miyan contributes to supervision, review, and editing. Dr. Srinivas Talabattula contributes to supervision, review, and editing.
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Nagarathnegowda, M., Raga, S., Gowre, S.K. et al. A Gallium arsenide composite semi-conductive material-based 2D photonic crystal biosensor for cancer cell detection. Opt Quant Electron 55, 1090 (2023). https://doi.org/10.1007/s11082-023-05281-y
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DOI: https://doi.org/10.1007/s11082-023-05281-y