Abstract
In this paper, a biosensors based on a two-dimensional photonic crystal (2D PhC) waveguide including a ring resonator is designed and simulated based on refractive index changes of red blood cells. The proposed biosensor structure consists of an elliptical photonic crystal ring resonator and two linear waveguides containing silicon nitride rods in a 2D rectangular lattice with circular rods. The biosensor is utilized to detect the stages of the Plasmodium falciparum cycle in red blood cells and to diagnose malaria disease. The proposed design distinguishes with high sensitivity between normal red blood cells and cells infected with Plasmodium falciparum. This biosensor is very compact, consists of gold rods in the air background and works very well at two input central wavelengths of 0.514 and 1.55 μm. The finite-difference time-domain (FDTD) method is used to simulate and investigate the device. The biosensor is extremely compact which is very suitable for lab-on-chip applications and exhibits higher sensitivity at both input central wavelengths compared with that of previously reported sensors.
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Akpa Marcel, A., Konan, K., Tokou, Z., Kossonou, Y., Dion, S., Kaduki, K., Zoueu, J.: Malaria-infected red blood cell analysis through optical and biochemical parameters using the transport of intensity equation and the microscope’s optical properties. Sensors. 19(14), 1–14 (2019). https://doi.org/10.3390/s19143045
Bååk, T.: Silicon oxynitride; a material for GRIN optics. Appl Opt. 21(6), 1069–1072 (1982). https://doi.org/10.1364/AO.21.001069
Barbillon, G., Bijeon, J.L., Plain, J., Lamy de la Chapelle, M., Adam, P.M., Royer, P.: Electron beam lithography designed chemical nanosensors based on localized surface plasmon resonance. Surf. Sci. 601(21), 5057–5061 (2007). https://doi.org/10.1016/j.susc.2007.09.005
Barroso, Á., Radhakrishnan, R., Ketelhut, S., Schnekenburger, J., Kemper, B.: Refractive index determination of buffer solutions from visible to near-infrared spectral range for multispectral quantitative phase imaging using a calibrated abbe refractometer. Quant Phase Imag 10887, 1–8 (2019). https://doi.org/10.1117/12.2509221
Bendib, S., Bendib, C.: Photonic crystals for malaria detection. J. Biosens. Bioelectron. (2018). https://doi.org/10.4172/2155-6210.1000257
Bilal, M., Saleem, M., Amanat, S., Shakoor, H., Rashid, R., Mahmood, A., Ahmed, M.: Optical diagnosis of malaria infection in human plasma using Raman spectroscopy. J. Biomed. Opt. 20(1), 1–8 (2015). https://doi.org/10.1117/1.JBO.20.1.017002
Cai, Z., Yan, Y., Liu, L., Lin, S., Hu, X.: Controllable fabrication of metallic photonic crystals for ultra-sensitive SERS and photodetectors. RSC Adv. 7, 55851–55858 (2017). https://doi.org/10.1039/C7RA11721C
Chen, N., Chang, M., Zhang, X., Zhou, J., Lu, X., Zhuang, S.: Highly sensitive plasmonic sensor based on a dual-side polished photonic crystal fiber for component content sensing applications. Nanomaterials 9, 1–11 (2019). https://doi.org/10.3390/nano9111587
Chopra, H., Kaler, R.S., Painam, B.: Photonic crystal waveguide-based biosensor for detection of diseases. J. Nanophoton. 10, 1–10 (2016). https://doi.org/10.1117/1.JNP.10.036011
Cleary, A., Clark, A., Glidle, A., Cooper, J., Cumming, D.: Fabrication of double split metallic nanorings for Raman sensing. Microelectron. Eng. 86, 1146–1149 (2009). https://doi.org/10.1016/j.mee.2009.02.008
Degirmenci, E., Landais, P.: Finite element method analysis of band gap and transmission of two-dimensional metallic photonic crystals at terahertz frequencies. Appl. Opt. 52, 7367–7375 (2013). https://doi.org/10.1364/AO.52.007367
Dell’Olio, F., Passaro, V.: Optical sensing by optimized silicon slot waveguides. Opt. Express 15, 4977–4993 (2007). https://doi.org/10.1364/OE.15.004977
Dharmadhikari, A., Basu, H., Dharmadhikari, J., Sharma, S., Mathur, D.: On the birefringence of healthy and malaria-infected red blood cells. J. Biomed. Opt. 18, 1–6 (2013). https://doi.org/10.1117/1.JBO.18.12.125001
Dhawan, A., Gerhold, M., Vo-Dinh, T.: Theoretical simulation and focused ion beam fabrication of gold nanostructures for surface-enhanced raman scattering (SERS). NanoBiotechnology 3(3–4), 164–171 (2007). https://doi.org/10.1007/s12030-008-9017-x
Divya, J., Selvendran, S., Avaninathan, S.: Photonic crystal-based optical biosensor: A brief investigation. Laser Physics. 28(6), 1-8 (2018). https://doi.org/10.1088/1555-6611/aab7d2
Hameed, M.F.O., Heikal, A., Younis, B., Abdelrazzak, M., Obayya, S.: Ultra-high tunable liquid crystal-plasmonic photonic crystal fiber polarization filter. Opt. Express 23, 7007–7020 (2015). https://doi.org/10.1364/OE.23.007007
Hassani, A., Skorobogatiy, M.: Photonic crystal fiber-based plasmonic sensors for the detection of biolayer thickness. JOSA B 26, 1550–1557 (2009). https://doi.org/10.1364/JOSAB.26.001550
Hoa, X.D., Martin, M., Jimenez, A., Beauvais, J., Charette, P., Kirk, A., Tabrizian, M.: Fabrication and characterization of patterned immobilization of quantum dots on metallic nano-gratings. Biosens. Bioelectron. 24(4), 970–975 (2008). https://doi.org/10.1016/j.bios.2008.07.069
Hsiao, F.L., Lee, C.: Computational study of photonic crystals nano-ring resonator for biochemical sensing. IEEE Sens. J. 10, 1185–1191 (2010). https://doi.org/10.1109/JSEN.2010.2040172
Jin, M., Pully, V.V., Otto, C., Van den Berg, A., Carlen, E.: High-density periodic arrays of self-aligned subwavelength nanopyramids for surface-enhanced Raman spectroscopy. J. Phys. Chem. c. 114(50), 21953–21959 (2010). https://doi.org/10.1021/jp106245a
Jindal, S., Sobti, S., Kumar, M., Sharma, S., Pal, M.: Nanocavity-coupled photonic crystal waveguide as highly sensitive platform for cancer detection. IEEE Sens. J. 16, 3705–3710 (2016). https://doi.org/10.1109/JSEN.2016.2536105
Kalyani, V., Sharma, V.: Design two dimensional nanocavity photonic crystal biosensor detection in malaria. Int. J. Emerg. Res. Manage. Technol. 6, 16–20 (2017). https://doi.org/10.23956/ijermt.v6i6.239
Koh, A.L., Fernández, A.I., McComb, D.W., Maier, S.A., Yang, J.K.W.: High-resolution mapping of electron-beam-excited plasmon modes in lithographically defined gold nanostructures. Nano Lett. 11(3), 1323–1330 (2011). https://doi.org/10.1021/nl104410t
Krampa, F., Aniweh, Y., Kanyong, P., Awandare, G.: Recent advances in the development of biosensors for malaria diagnosis. Sensors. 20(3), 1–21 (2020). https://doi.org/10.3390/s20030799
Krishnan, S., Robinson, S.: Two-dimensional photonic crystal based sensor for pressure sensing. Photon. Sens. 4, 248–253 (2014). https://doi.org/10.1007/s13320-014-0198-8
Liu, P.Y., Chin, L.K., Ser, W., Chen, H., Hsieh, C.-M., Lee, C.-H., Sung, K.-B., Ayi, T., Yap, P., Liedberg, B., Wang, K., Bourouina, T., Leprince-Wang, Y.: Cell refractive index for cell biology and disease diagnosis: past, present and future. Lab Chip 16(4), 634–644 (2016). https://doi.org/10.1039/c5lc01445j
Liu, W., Yan, J., Shi, Y.: High sensitivity visible light refractive index sensor based on high order mode Si3N4 photonic crystal nanobeam cavity. Opt. Express 25(25), 31739–31745 (2017). https://doi.org/10.1364/OE.25.031739
Luke, K., Okawachi, Y., Lamont, M., Gaeta, A., Lipson, M.: Broadband mid-infrared frequency comb generation in a Si3N4 microresonator CLEO science and innovations CLEO-SI 2015. STu4I (2015). https://doi.org/10.1364/CLEO_SI.2015.STu4I.8
Mai, T., Hsiao, F.L., Lee, C., Xiang, W., Chen, C.L., Choi, W.K.: Optimization and comparison of photonic crystal resonators for silicon microcantilever sensors. Sens. Actuat., A 165, 16–25 (2011). https://doi.org/10.1016/j.sna.2010.01.006
Mohammed, N.A., Hamed, M.H., Khalaf, A.M.M., Alsayyari, A., El-Rabaie, E.S.: High-sensitivity ultra-quality factor and remarkable compact blood components biomedical sensor based on nanocavity coupled photonic crystal. Results Phys. 14, 1–9 (2019). https://doi.org/10.1016/j.rinp.2019.102478
Mohammed, N., Hamed, M., Khalaf, A.A.M., El-Rabaie, E.S.: Malaria biosensors with ultra-sensitivity and quality factor based on cavity photonic crystal designs. Euro. Phys. J. Plus. 135, 1–22 (2020). https://doi.org/10.1140/epjp/s13360-020-00940-5
Molina-Franky, J., Cuy-Chaparro, L., Camargo, A., Reyes, C., Gómez, M., Salamanca, D., Patarroyo, M., Patarroyo, M.: Plasmodium falciparum pre-erythrocytic stage vaccine development. Malaria J (2020). https://doi.org/10.1186/s12936-020-3141-z
Nureye, D., Assefa, S.: Old and recent advances in life cycle, pathogenesis, diagnosis, prevention, and treatment of malaria including perspectives in Ethiopia. Sci. World J. 2020, 1–17 (2020). https://doi.org/10.1155/2020/1295381
Park, Y.K., Diez-Silva, M., Popescu, G., Lykotrafitis, G., Choi, W., Feld, M., Suresh, S.: Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum. Proc. Natl. Acad. Sci. U.S.A. 105, 13730–13735 (2008). https://doi.org/10.1073/pnas.0806100105
Porcel, M.A.G., Hinojosa, A., Jans, H., Stassen, A., Goyvaerts, J., Geuzebroek, D., Geiselmann, M., Dominguez, C., Artundo, I.: Silicon nitride photonic integration for visible light applications. Opt Laser Technol 112, 299–306 (2019). https://doi.org/10.1016/j.optlastec.2018.10.059
Ragavan, K.V., Kumar, S., Swaraj, S., Neethirajan, S.: Advances in biosensors and optical assays for diagnosis and detection of malaria. Biosens Bioelectron. 105, 188–210 (2018). https://doi.org/10.1016/j.bios.2018.01.037
Rajasekar, R., Robinson, S.: Nano-pressure and temperature sensor based on hexagonal photonic crystal ring resonator. Plasmonics 14, 3–15 (2018). https://doi.org/10.1007/s11468-018-0771-x
Rajendran, A., Suaganya, T., Robinson, S.: Design and analysis of 2D photonic crystal based biosensor to detect different blood components. Photon. Sens. 9, 69–77 (2018). https://doi.org/10.1007/s13320-018-0479-8
Rifat, A.A., Rabiul Hasan, M.D., Ahmed, R., Miroshnichenko, A.E.: Microstructured optical fiber-based plasmonic sensors. In: Obayya, S., Hameed, M.F.O. (eds.) Computational photonic sensors, pp. 203–232. Springer, Switzerland (2019)
Robinson, S., Dhanlaksmi, N.: Photonic crystal based biosensor for the detection of glucose concentration in urine. Photon. Sens. (2016). https://doi.org/10.1007/s13320-016-0347-3
Segawa, H., Ueno, K., Yokota, Y., Misawa, H., Yano, T., Shibata, S.: Nano-patterning of a TiO2-organic hybrid material assisted by a localized surface plasmon. J. Am. Ceram. Soc. 93(6), 1634–1638 (2010). https://doi.org/10.1111/j.1551-2916.2010.03645.x
Sharma, P., Sharan, P.: Design of photonic crystal based ring resonator for detection of different blood constituents. Opt. Commun. 348, 19–23 (2015). https://doi.org/10.1016/j.optcom.2015.03.015
Stodolka, J., Nau, D., Frommberger, M., Zanke, C., Giessen, H., Quandt, E.: Fabrication of two-dimensional hybrid photonic crystals utilizing electron beam lithography. Microelectron. Eng. 78–79, 442–447 (2005). https://doi.org/10.1016/j.mee.2004.12.056
Subramanian, A., Ryckeboer, E., Dhakal, A., Peyskens, F., Malik, A., Kuyken, B., Zhao, H., Pathak, S., Ruocco, A., De Groote, A., Wuytens, P., Martens, D., Leo, F., Xie, W., Dave, U., Muneeb, M., Van Dorpe, P., Van Campenhout, J., Bogaerts, W., Baets, R.: Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]. Photon. Res. 3, B47–B59 (2015). https://doi.org/10.1364/PRJ.3.000B47
Zegadi, R., Lahcene, Z., Zegadi, A.: Design of high sensitive temperature sensor based on two-dimensional photonic crystal. Silicon 12, 1–7 (2019). https://doi.org/10.1007/s12633-019-00303-5
Zhang, Y.N., Zhao, Y., Tianmin, Z., Ql, Wu.: Applications and developments of on-chip biochemical sensors based on optofluidic photonic crystal cavities. Lab Chip 18, 57–74 (2017). https://doi.org/10.1039/C7LC00641A
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Rashidnia, A., Pakarzadeh, H., Hatami, M. et al. Photonic crystal-based biosensor for detection of human red blood cells parasitized by plasmodium falciparum. Opt Quant Electron 54, 38 (2022). https://doi.org/10.1007/s11082-021-03421-w
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DOI: https://doi.org/10.1007/s11082-021-03421-w