Abstract
Diffuse optical imaging enables to reconstruct distribution of optical properties, absorption and scattering coefficients, in tissue for breast cancer detection based on diffusion equation with the help of the initial guess obtained from measured data. To estimate the initial guess of the optical-property coefficients, an analytical solution of diffusion equation can be used and compared with the measured data. The analytical solution for a homogeneous infinite medium can be obtained in the frequency domain, expressing that the photon intensity and the phase lag relative to the distance between source and detector in a linear relationship. In this study, a succinct calculation using the trigonometric relation is proposed to estimate the optical-property coefficients. A tank-type and a cylinder Lipovenoes phantoms with two concentrations of 1.25% and 2.5% are employed and measured for verification. It is found that the method proposed here shows better results and results in estimation errors of 0–14.81% for μa and 20–42% for μs′.
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This research was financially supported by the Ministry of Science and Technology in Taiwan through grants MOST 105-2221-E-008-045 and MOST 106-2221-E-008-046.
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This article is part of the Topical Collection on Optics in Materials, Energy and Related Technologies 2018.
Guest Edited by Yen-Hsun Su, Songnan Qu, Yiting Yu, Wei Zhang.
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Pan, MC., Yu, JM., Chen, LY. et al. Optical-property coefficient estimation of bulky medium in experiments with a succinctly analytical calculation. Opt Quant Electron 51, 33 (2019). https://doi.org/10.1007/s11082-019-1747-6
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DOI: https://doi.org/10.1007/s11082-019-1747-6