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Neuronal synchronization enhanced by neuron–astrocyte interaction

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Abstract

In this study, we consider the problem of signal processing in neuron–astrocyte networks where the intercellular communication is described on the basis of a tripartite synapse concept. This type of communication involves combined contributions of pre- and postsynaptic neuronal compartments and components of the surrounding astrocyte to the processes of information transmission. Astrocyte-mediated regulation of neuronal activity is considered through the analysis of the response changes in the classical Hodgkin–Huxley model driven by excitatory synaptic current. It is shown that the complicated astrocyte-dependent dynamics of this current can lead to non-trivial changes in individual postsynaptic neuronal activity and, hence, in the cooperative activation of neuronal groups linked by the “astrocyte-mediated bridge”.

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Acknowledgements

The numerical computations were carried out on high-performance cluster of Lobachevsky State University of Nizhny Novgorod.

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Authors and Affiliations

  1. Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    Evgeniya V. Pankratova & Alena I. Kalyakulina

  2. Center of Translational Technologies, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia

    Sergey V. Stasenko, Susanna Yu. Gordleeva, Ivan A. Lazarevich & Viktor B. Kazantsev

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  1. Evgeniya V. Pankratova
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  2. Alena I. Kalyakulina
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  3. Sergey V. Stasenko
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  4. Susanna Yu. Gordleeva
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  5. Ivan A. Lazarevich
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  6. Viktor B. Kazantsev
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Correspondence to Evgeniya V. Pankratova.

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The work was supported by the Ministry of Science and Higher Education of the Russian Federation (Project No. 14.Y26.31.0022).

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Pankratova, E.V., Kalyakulina, A.I., Stasenko, S.V. et al. Neuronal synchronization enhanced by neuron–astrocyte interaction. Nonlinear Dyn 97, 647–662 (2019). https://doi.org/10.1007/s11071-019-05004-7

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