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Cell type-specific dendritic polarity in the absence of spatially organized external cues

Brain Cell Biology volume 35, pages 29–38 (2006)Cite this article

Abstract

Pyramidal neurons of the hippocampus and cortex have polarized dendritic arbors, but little is known about the cellular mechanisms distinguishing apical and basal dendrites. We used morphometric analysis and time lapse imaging of cultured hippocampal neurons to show that glutamatergic neurons develop progressive dendritic asymmetry in the absence of polarized extrinsic cues. Thus, pyramidal neurons have a cellular program for polarized dendrite growth independent of tissue microenvironment.

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Affiliations

  1. Department of Neurobiology, Durham, NC, 27710, USA

    April C. Horton & Michael D. Ehlers

  2. Department of Pharmacology and Cancer Biology, Durham, NC, 27710, USA

    Jason J. Yi & Michael D. Ehlers

  3. Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC, 27710, USA

    Michael D. Ehlers

Authors
  1. April C. Horton
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  2. Jason J. Yi
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  3. Michael D. Ehlers
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Correspondence to Michael D. Ehlers.

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Horton, A.C., Yi, J.J. & Ehlers, M.D. Cell type-specific dendritic polarity in the absence of spatially organized external cues. Brain Cell Bio 35, 29–38 (2006). https://doi.org/10.1007/s11068-006-9003-y

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  • DOI: https://doi.org/10.1007/s11068-006-9003-y

Keywords

  • Hippocampal Neuron
  • Pyramidal Neuron
  • GABAergic Neuron
  • Primary Dendrite
  • Dendritic Arbor