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Neuropsychological Impact of Trauma-Related Mental Illnesses: A Systematic Review of Clinically Meaningful Results

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Abstract

A trauma history is present in approximately 90% of adults in the United States. Comparatively, lifetime post-traumatic stress disorder (PTSD) prevalence is only 8.3% (Kilpatrick et al. Journal of Traumatic Stress, 26, 537-547, 2013). A neuropsychological understanding of trauma is essential to effective trauma-informed assessments and treatments. Prior reviews have focused on PTSD, specific neuropsychological domains, and statistically rather than clinically significant results. The current systematic review investigated standardized test performance across neuropsychological domains in participants with trauma histories and any psychiatric diagnosis. The review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. From 2350 records, the search returned 21 eligible studies: 8 for combat trauma, 2 for childhood trauma, 2 for intimate partner violence and sexual assault, 2 for accidental trauma, 1 for refugee trauma, and 6 for unspecified trauma. Mean neuropsychological scores ranged from low to high average, with one mean verbal memory score in the borderline range. These findings diverge from reports of between-group differences or experimental task performance, which suggest greater levels of static cognitive impairment. Current results are limited by lack of distinction between trauma types in the literature, a dearth of cognitive domains examined, wide use of self-report trauma measures, and publication and outcome reporting biases. Clinical implications for assessment and rehabilitation are discussed in relation to clinical significance, state versus trait based changes, intra-individual variability, changes from pre- to post-trauma, and within-group variability in resilience. Future directions are recommended in consideration of cultural factors, prospective and follow-up designs, and psychiatric diagnosis.

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References

  • American Psychiatric Association. (2013). Trauma and stressor-related disorders: In Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Publishing.

    Google Scholar 

  • Bae, S. M., Hyun, M. H., & Lee, S. H. (2014). Comparison of memory function and MMPI-2 profile between post-traumatic stress disorder and adjustment disorder after a traffic accident. Korean College of Neuropsychopharmacology, 12, 41–47.

    Google Scholar 

  • Banks, M. E. (2007). Overlooked but critical: Traumatic brain injury as a consequence of interpersonal violence. Trauma, Violence, and Abuse, 8(3), 290–298.

    PubMed  Google Scholar 

  • Bensley, L., Van Eenwyk, J., & Simmons, K. W. (2003). Childhood family violence history and women’s risk for intimate partner violence and poor health. American Journal of Preventive Medicine, 25(1), 38–44.

    PubMed  Google Scholar 

  • BC Mental Health & Substance Use Services. (2013). Trauma-informed practice guide. Resource document. BC Mental Health & Substance Use Services. http://bccewh.bc.ca/wp-content/uploads/2012/05/2013_TIP-Guide.pdf. Accessed 15 March 2018.

  • Bremner, J. D., & Pearce, B. (2016). Neurotransmitter, neurohormonal, and neuropeptidal function in stress and PTSD. In J. D. Bremner (Ed.), Posttraumatic stress disorder: From neurobiology to treatment (pp. 181–232). New Jersey: Wiley.

    Google Scholar 

  • Bryant, R. (2011). Post-traumatic stress disorder vs traumatic brain injury. Dialogues in Clinical Neuroscience, 13(3), 251–262.

    PubMed  PubMed Central  Google Scholar 

  • Bryant, R., Marosszeky, J. E., Crooks, J., & Gurka, J. A. (2000). Posttraumatic stress disorder after severe traumatic brain injury. The American Journal of Psychiatry, 157(4), 629–631.

    CAS  PubMed  Google Scholar 

  • Campbell, C., Barrett, S., Shannon, C., Hoy, K., Rushe, T., Cooper, S., & Mulholland, C. (2013). The relationship between childhood trauma and neuropsychological functioning in first episode psychosis. Psychosis: Psychological, Social and Integrative Approaches, 5(1), 48–59.

    Google Scholar 

  • Chiesa, A., Serretti, A., & Jakobsen, J. C. (2013). Mindfulness: Top–down or bottom–up emotion regulation strategy? Clinical Psychology Review, 33(1), 82–96.

    PubMed  Google Scholar 

  • Chung, S. Y., Tang, S. H., Shie, J. P., Tsai, K. Y., & Chou, F. H. C. (2014). Emotional memory and posttraumatic stress disorder: A neuropsychological study in female victims of domestic violence. Journal of Psychiatry, 17, 14–96.

    Google Scholar 

  • Clare, L., & Woods, R. T. (2004). Cognitive training and cognitive rehabilitation for people with early-stage Alzheimer’s disease: A review. Neuropsychological Rehabilitation, 14, 285–401.

    Google Scholar 

  • Combs, H. L., Berry, D. T. R., Pape, T., Babcock-Parziale, J., Smith, B., Schleenbaker, R., & …High Jr, W.M. (2015). The effects of mild traumatic brain injury, post-traumatic stress disorder, and combined mild traumatic brain injury/post-traumatic stress disorder on returning veterans. Journal of Neurotrauma, 32(13), 956–966.

  • Cooper, D.B., Curtiss, G., Armistead-Jehle, P., Belanger, H.G., Tate, D., Reid, M., … Vanderploeg, R.D. (2018). Neuropsychological performance and subjective symptom reporting in military service members with a history of multiple concussions: Comparison with a single concussion, posttraumatic stress disorder, and orthopedic trauma. The Journal of Head Trauma Rehabilitation, 33, 81–90

  • Currier, J. M., Holland, J. M., & Malott, J. (2015). Moral injury, meaning making, and mental health in returning veterans. Journal of Clinical Psychology, 71, 229–240.

    PubMed  Google Scholar 

  • Daly, B. P., Hildenbrand, A. K., Turner, E., Berkowitz, S., & Tarazi, R. A. (2017). Executive functioning among college students with and without history of maltreatment. Journal of Aggression, Maltreatment, & Trauma, 26(7), 717–735.

    Google Scholar 

  • Dannlowski, U., Kugel, H., Huber, F., Stuhrmann, A., Redlich, D., Grotegerd, D., … Suslow, T. (2013). Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala. Human Brain Mapping, 34(11), 2899–2909.

    PubMed  Google Scholar 

  • Daniels, J. K., Frewen, P., McKinnon, M. C., & Lanius, R. A. (2011). Default mode alterations in posttraumatic stress disorder related to early-life trauma: A developmental perspective. Journal of Psychiatry & Neuroscience, 36(1), 56–59.

    Google Scholar 

  • Disner, S. G., Kramer, M. D., Nelson, N. W., Lipinski, A. J., Christensen, J. M., Polusny, M. A., & Sponheim, S. R. (2017). Predictors of postdeployment functioning in combat-exposed U.S. military veterans. Clinical Psychological Science, 5(4), 650–663.

    Google Scholar 

  • Dolan, S., Martindale, S., Robinson, J., Kimbrel, N. A., Meyer, E. C., Kruse, M. I., & …Gulliver, S.B. (2012). Neuropsychological sequelae of PTSD and TBI following war deployment among OEF/OIF veterans. Neuropsychology Review, 22(1), 21–34.

  • Dunkley, B. T., Sedge, P. A., Doesburg, S. M., Grodecki, R. J., Jetly, R., Shek, P. N., … Pang, E. W. (2015). Theta, mental flexibility, and post-traumatic stress disorder: Connecting in the parietal cortex. PLos ONE, 10, e0123541.

    PubMed  PubMed Central  Google Scholar 

  • Dwan, K., Gamble, C., Williamson, P.R., & Kirkham, J.J. (2013). Systematic review of the empirical evidence of study publication bias and outcome reporting bias: An updated review. PLoS ONE, 8, e66844

  • Edmondson, D., Richardson, S., Fausett, J. K., Falzon, L., Howard, V. J., & Kronish, I. M. (2013). Prevalence of PTSD in survivors of stroke and transient ischemic attack: A meta-analytic review. PLoS One, 8, 1–6.

    Google Scholar 

  • Ehlers, A., & Clark, D. M. (2000). A cognitive model of posttraumatic stress disorder. Behaviour Research and Therapy, 38(4), 319–345.

    CAS  PubMed  Google Scholar 

  • El Khoury-Malhame, M., Reynaud, E., Soriano, A., Michael, K., Salgado-Pineda, P., Zendjidjian, X., … Khalfa, S. (2011). Amygdala activity correlates with attentional bias in PTSD. Neuropsychologia, 49(7), 1969–1973.

    PubMed  Google Scholar 

  • Etkin, A., Egner, T., & Kalisch, R. (2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences, 15(2), 85–93.

    PubMed  Google Scholar 

  • Flaks, M. K., Malta, S. M., Almeida, P. P., Bueno, O. F. A., Pupos, M. C., Andreoli, S. B., … Bressan, R. A. (2014). Attentional and executive functions are differentially affected by post-traumatic stress disorder and trauma. Journal of Psychiatric Research, 48(1), 32–49.

    PubMed  Google Scholar 

  • Francati, V., Vermetten, E., & Bremner, J. D. (2007). Functional neuroimaging studies in posttraumatic stress disorder: Review of current methods and findings. Depression and Anxiety, 24(3), 202–218.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fortenbaugh, F. C., Corbo, V. C., Poole, V., McGlinchey, R., Milberg, W., Salat, D., … Esterman, M. (2017). Interpersonal early-life trauma alters amygdala connectivity and sustained attention performance. Brain and Behaviour, 7, 1–16.

  • Fortier-Brochu, E., & Morin, C. M. (2014). Cognitive impairment in individuals with insomnia: Clinical significance and correlates. Sleep, 37(11), 1787–1798.

    PubMed  PubMed Central  Google Scholar 

  • Gabowitz, D., Zucker, M., & Cook, A. (2008). Neuropsychological assessment in clinical evaluation of children and adolescents with complex trauma. Journal of Child and Adolescent Trauma, 1(2), 163–178.

    Google Scholar 

  • Gilbertson, M. W., Paulus, L. A., Williston, S. K., Gurvits, T. V., Lasko, N. B., Pitman, R. K., & Orr, S. P. (2006). Neurocogntive function in monozygotic twins discordant for combat exposure: Relationship to posttraumatic stress disorder. Journal of Abnormal Psychology, 115(3), 484–495.

    PubMed  Google Scholar 

  • Goebel, S., Strenge, H., & Mehdorn, H. M. (2012). Acute stress in patients with brain cancer during primary care. Supportive Care in Cancer, 20(7), 1425–1434.

    PubMed  Google Scholar 

  • Grigorovich, A., Gomez, M., Leach, L., & Fish, J. (2013). Impact of posttraumatic stress disorder and depression on neuropsychological functioning in electrical injury survivors. Journal of Burn Care & Research, 34(6), 659–665.

    Google Scholar 

  • Jelinek, L., Jacobsen, D., Kellner, M., Larbig, F., Biesold, K. H., Barre, K., & Moritz, S. (2006). Verbal and nonverbal memory functioning in posttraumatic stress disorder (PTSD). Clinical and Experimental Neuropsychology, 28, 940–948.

    Google Scholar 

  • Johnsen, G. E., & Asbjørnsen, A. E. (2008). Consistent impaired verbal memory in PTSD: A meta-analysis. Journal of Affective Disorders, 111, 74–82.

    PubMed  Google Scholar 

  • Kaplan, G. B., Leite-Morris, K. A., Wang, L., Rumbika, K. K., Heinrichs, S. C., Zeng, X., et al. (2017). Pathophysiological bases of comorbidity: TBI and PTSD. Journal of Neurotrauma, 1–51.

  • Karr, J. E., Rau, H. K., Shofer, J. B., Hendrickson, R. C., Peskind, E. R., & Pagulayan, K. F. (2019). Variables associated with subjective cognitive change among Iraq and Afghanistan war veterans with blast-related mild traumatic brain injury. Journal of Clinical and Experimental Neuropsychology, 41(7), 680–693.

    PubMed  Google Scholar 

  • Karr, J. E., Areshenkoff, C. N., Duggan, E. C., & Garcia-Barrera, M. A. (2014). Blast-related mild traumatic brain injury: A Bayesian random-effects meta-analysis on the cognitive outcomes of concussion among military personnel. Neuropsychology Review, 24(4), 428–444.

    PubMed  Google Scholar 

  • Kelly-Irving, M., Mabile, L., Grosclaude, P., Lang, T., & Delpierre, C. (2013). The embodiment of adverse childhood experiences and cancer development: Potential biological mechanisms and pathways across the life course. International Journal of Public Health, 58(1), 3–11.

    PubMed  Google Scholar 

  • Killgore, W. D. S. (2010). Effects of sleep deprivation on cognition. In G. A. Kerkhof & H. P. A. Van Dongen (Eds.), Progress in Brain Research (vol. 185, pp. 105–129). Amsterdam: Elsevier.

  • Kilpatrick, D. G., Resnick, H. S., Milanak, M. E., Miller, M. W., Keyes, K. M., & Friedman, M. J. (2013). National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria. Journal of Traumatic Stress, 26(5), 537–547.

    PubMed  PubMed Central  Google Scholar 

  • Kitayama, N., Vaccarino, V., Kutner, M., Weiss, P., & Bremner, J. D. (2005). Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis. Journal of Affective Disorders, 88(1), 79–86.

    PubMed  Google Scholar 

  • Lanius, R. A., Vermetten, E., Loewenstein, R. J., Brand, B., Schmahl, C., Bremner, J. D., & Spiegel, D. (2010). Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype. American Journal of Psychiatry, 167(6), 640–647.

    PubMed  Google Scholar 

  • Lee, M. S., & DePrince, A. P. (2017). Impact of executive function on efficacy obtaining resources following intimate partner violence. Journal of Community Psychology, 45, 705–714.

    Google Scholar 

  • Lindauer, R. J., Olff, M., van Meijel, E. P., Carlier, I. V., & Gersons, B. P. (2006). Cortisol, learning, memory, and attention in relation to smaller hippocampal volume in police officers with posttraumatic stress disorder. Biological Psychiatry, 59, 171–177.

    CAS  PubMed  Google Scholar 

  • Lipinska, M., Timol, R., Kaminer, D., & Thomas, K. G. F. (2014). Disrupted rapid eye movement sleep predicts poor declarative memory performance in post-traumatic stress disorder. Journal of Sleep Research, 23, 311–319.

    Google Scholar 

  • Lopez, K. C., Leary, J. B., Pham, D. L., Chou, Y. Y., Dsurney, J., & Chan, L. (2017). Brain volume, connectivity, and neuropsychological performance in mild traumatic brain injury: The impact of post-traumatic stress disorder symptoms. Journal of Neurotrauma, 34(1), 16–22.

    PubMed  PubMed Central  Google Scholar 

  • Lovallo, W.R., Farag, N.H., Sorocco, K.H., Acheson, A., Cohoon, A.J., & Vincent, A.S (2013). Early life adversity contributes to impaired cognition and impulsive behavior: Studies from the Oklahoma family health patterns project. Alcoholism: Clinical and Experimental Research, 37, 616–623, 4.

  • Lu, S., Pan, F., Gao, W., Wei, Z., Wang, D., Hu, S., … Li, L. (2017). Neural correlates of childhood trauma with executive function in young healthy adults. Oncotarget, 8(45), 79843–79853.

  • Luxenberg, T., Spinazzola, J., & van der Kolk, B. A. (2001). Complex trauma and disorders of extreme stress (DESNOS) diagnosis, part one: Assessment. Directions in Psychiatry, 21, 373–394.

    Google Scholar 

  • Malarbi, S., Abu-Rayya, H. M., Muscara, F., & Stargatt, R. (2017). Neuropsychological functioning of childhood trauma and post-traumatic stress disorder: A meta-analysis. Neuroscience and Biobehavioral Reviews, 72, 68–86.

    CAS  PubMed  Google Scholar 

  • Masson, M., East-Richard, C., & Cellard, C. (2016). A meta-analysis on the impact of psychiatric disorders and maltreatment on cognition. Neuropsychology, 30(2), 143–156.

    PubMed  Google Scholar 

  • Mattson, E. K., Nelson, N. W., Sponheim, S. R., & Disner, S. G. (2019). The impact of PTSD and mTBI on the relationship between subjective and objective cognitive deficits in combat-exposed veterans. Neuropsychology. Advance online publication.

  • Metcalfe, J., & Jacobs, W. J. (1996). A “hot-system/cool system” view of memory under stress. PTSD Research Quarterly, 7, 1–3.

    Google Scholar 

  • Meyers, J. E., Miller, R. M., & Tuita, A. R. R. (2014). Using pattern analysis matching to differentiate TBI and PTSD in a military sample. Applied Neuropsychology: Adult, 21(1), 60–68.

    Google Scholar 

  • Mink, M. D., Lindley, L. L., & Weinstein, A. A. (2014). Stress, stigma, and sexual minority status: The intersectional ecology model of LGBTQ health. Journal of Gay & Lesbian Social Services: The Quarterly Journal of Community & Clinical Practice, 26(4), 502–521.

    Google Scholar 

  • Morey, R. A., Dolcos, F., Petty, C. M., Cooper, D. A., Hayes, J. P., LaBar, K. S., & McCarthy, G. (2009). The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder. Journal of Psychiatric Research, 43(8), 809–817.

    PubMed  Google Scholar 

  • Motta, R. W., Joseph, J. M., Rose, R. D., Suozzi, J. M., & Leiderman, L. J. (1997). Secondary trauma: Assessing inter-generational transmission of war experiences with a modified stroop procedure. Journal of Clinical Psychology, 53(8), 895–903.

    CAS  PubMed  Google Scholar 

  • Myers, L., Zeng, R., Perrine, K., Lancman, M., & Lancman, M. (2014). Cognitive differences between patients who have psychogenic nonepileptic seizures (PNESs) and posttraumatic stress disorder (PTSD) and patients who have PNESs without PTSD. Epilepsy & Behaviour, 37, 82–86.

    Google Scholar 

  • Orme, D. R. (2012). Diagnosing PTSD: Lessons from neuropsychology. Military Psychology, 24(4), 397–413.

    Google Scholar 

  • Parlar, M., Frewen, P. A., Oremus, C., Lanius, R. A., & McKinnon, M. C. (2016). Dissociative symptoms are associated with reduced neuropsychological performance in patients with recurrent depression and a history of trauma exposure. European Journal of Psychotraumatology, 7, article, 29061.

    PubMed  Google Scholar 

  • Parslow, A., & Jorm, A. F. (2007). Pretrauma and posttrauma neurocognitive functioning and PTSD symptoms in a community sample of young adults. American Journal of Psychiatry, 164(3), 509–515.

    PubMed  Google Scholar 

  • Peterson, A., Thome, J., Frewen, P., & Lanius, R. A. (2014). Resting-state neuroimaging studies: A new way of identifying differences and similarities. Canadian Journal of Psychiatry, 59(6), 294–300.

    PubMed  Google Scholar 

  • Pineles, S. L., Shipherd, J. C., Mostoufi, S. M., Abramovitz, M., & Yovel, I. (2009). Attentional biases in PTSD: More evidence for interference. Behavour Research and Therapy, 47(12), 1050–1057.

    Google Scholar 

  • Polak, A. R., Witteveen, A. B., Reitsma, J. B., & Olff, M. (2012). Executive function in posttraumatic stress disorder: A systematic review. Journal of Affective Disorders, 141(1), 11–21.

    PubMed  Google Scholar 

  • Qureshi, S. U., Long, M. E., Bradshaw, M. R., Pyne, J. M., Magruder, K. M., Kimbrell, T., … Kunik, M. E. (2011). Does PTSD impair cognition beyond the effect of trauma? The Journal of Neuropschiatry and Clinical Neurosciences, 23(1), 16–28.

  • Ray, L. A., Bujarski, S., Yardley, M., Roche, D. J., & Hartwell, E. (2017). Differences between treatment-seeking and non-treatment-seeking participants in medication studies for alcoholism: Do they matter? The American Journal of Drug and Alcohol Abuse, 43(6), 703–710.

    PubMed  PubMed Central  Google Scholar 

  • Roberts, A., Austin, S., Corliss, H., Vandermorris, A., & Koenen, K. (2010). Pervasive trauma exposure among U.S. sexual orientation minority adults and risk of posttraumatic stress disorder. American Journal of Public Health, 100(12), 2433–2441.

    PubMed  PubMed Central  Google Scholar 

  • Rivera-Veléz, G. M., González-Viruet, M., Martínez-Taboas, A., & Peréz-Mojica, D. (2014). Post- traumatic stress disorder, dissociation, and neuropsychological performance in Latina victims of childhood sexual abuse. Journal of Child Sex Abuse, 25, 55–73.

    Google Scholar 

  • Samuelson, K. W., Abadjian, L., Jordan, J. T., Bartel, A., Vasterling, J., & Seal, K. (2017). The association between PTSD and functional outcome is mediated by perception of cognitive problems rather than objective neuropsychological test performance. Journal of Traumatic Stress, 30, 520–530.

    Google Scholar 

  • Sangalang, C. C., & Vang, C. (2017). Intergenerational trauma in refugee families: A systematic review. Journal of Immigrant and Minority Health, 19(3), 745–754.

    PubMed  PubMed Central  Google Scholar 

  • Scheiner, D. L., Keilp, J., Mindt, M. R., Burke, A. K., Oquendo, M. A., & Mann, J. J. (2014). Verbal learning deficits in posttraumatic stress disorder and depression. Journal of Traumatic Stress, 27(3), 291–298.

    PubMed  Google Scholar 

  • Scott, J. C., Matt, G. E., Wrocklage, K. M., Crnich, C. C., Jordan, J., Southwick, S. M., & Krystal, J.J.,& Schweinsburg, B.C. (2015). A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder. Psychological Bulletin, 1, 105–140.

  • Shandera-Ochsner, A. L., Berry, D. T. R., Harp, J. P., Edmundson, M., Graue, L. O., Roach, A., & High Jr., W. M. (2013). Neuropsychological effects of self-reported deployment-related mild TBI and current PTSD in OIF/OEF veterans. The Clinical Neuropsychologist, 27(6), 881–907.

    PubMed  Google Scholar 

  • Shin, J.E., Choi, C.H., Lee, J.M., Kon, J.S., Lee, S.H., Kim, H.C.,… Yoo, S.Y. (2017). Association between memory impairment and brain metabolite concentrations in north Korean refugees with posttraumatic stress disorder. PLos ONE, 12, article e0188953

  • Sidlei, L., Fisher, H. L., Russo, M., Murray, R. M., Stilo, S. A., Wiffren, B. D. R., … Di Forti, M. (2014). Failure to find association between childhood abuse and cognition in first-episode psychosis patients. European Psychiatry, 29(1), 32–35.

    Google Scholar 

  • Smart, C. M., Segalowitz, S. J., Mulligan, B., Koudys, J., & Gawryluk, J. R. (2016). Mindfulness training for older adults with subjective cognitive decline: Results from a pilot randomized controlled trial. Journal of Alzheimer’s Disease, 52(2), 757–774.

    PubMed  Google Scholar 

  • Soble, J. R., Spanierman, L. B., & Smith, J. F. (2013). Neuropsychological functioning of combat veterans with posttraumatic stress disorder and mild traumatic brain injury. Journal of Clinical and Experimental Neuropsychology, 35, 551–561.

    PubMed  Google Scholar 

  • Stein, M. B., Kennedy, C. M., & Twamley, E. W. (2002). Neuropsychological function in female victims of intimate partner violence with and without posttraumatic stress disorder. Biological Psychiatry, 52, 1079–1088.

    PubMed  Google Scholar 

  • Stein, M. B., & McAllister, T. W. (2009). Exploring the convergence of posttraumatic stress disorder and traumatic brain injury. The American Journal of Psychiatry, 166(7), 768–776.

    PubMed  Google Scholar 

  • Stricker, N. H., Lippa, S. M., Green, D. L., McGlynn, S. M., Grande, L. J., Milberg, W. P., & McGlinchey, R. E. (2017). Elevated rates of memory impairment in military service- members and veterans with posttraumatic stress disorder. Journal of Clinical and Experimental Neuropsychology, 39(8), 768–785.

    PubMed  Google Scholar 

  • Swick, D., Honzel, N., Larsen, J., & Ashley, V. (2013). Increased response variability as a marker of executive dysfunction in veterans with post-traumatic stress disorder. Neuropsychologia, 14, 3033–3040.

    Google Scholar 

  • Todd, R. M., MacDonald, M. J., Sedge, P., Robertson, A., Jetly, R., Taylor, M. J., & Pang, E. W. (2015). Soldiers with posttraumatic stress disorder see a world full of threat: Magnetoencephalography reveals enhanced tuning to combat-related cues. Biological Psychiatry, 78(12), 821–829.

    PubMed  Google Scholar 

  • Tyagi, A. & Cohen, M. (2016). Yoga and heart rate variability: A comprehensive review of the literature. International Journal of Yoga, 9, 97-113. U.S. Department of Veterans Affairs National Center for PTSD (2012). Using the PTSD checklist (PCL) [PDF file]. Retrieved from https://sph.umd.edu/sites/default/files/files/ PTSDChecklistScoring.PDF

  • Valentine, J. C., Pigott, T. D., & Rothstein, H. R. (2010). How many studies do you need?: A primer on statistical power for meta-analysis. Journal of Educational and Behavioral Statistics, 35(2), 215–247.

    Google Scholar 

  • Van Der Kolk, B. A. (2006). Clinical implications of neuroscience research in PTSD. Annals of the New York Academy of Sciences, 1071(1), 277–293.

    PubMed  Google Scholar 

  • Van Der Kolk, B. A. (2015). The body keeps the score: Brain, mind, and body in the healing of trauma. New York: Penguin Books.

    Google Scholar 

  • Vasterling, J. J., Brailey, K., Proctor, S. P., Kane, R., Heeren, T., & Franz, M. (2012). Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers. The British Journal of, Neuropsychological outcomes of mild traumatic brain injury, post-traumatic stress disorder and depression in Iraq-deployed US Army soldiers Psychiatry, 201, 186–192.

    Google Scholar 

  • Vasterling, J. J., & Proctor, S. P. (2011). Understanding the neuropsychological consequences of deployment stress: A public health framework. Journal of the International Neuropsychological Society, 17(01), 1–6.

    PubMed  Google Scholar 

  • Vasterling, J. J., Verfaellie, M., & Sullivan, K. D. (2009). Mild traumatic brain injury and posttraumatic stress disorder in returning veterans: Perspectives from cognitive neuroscience. Clinical Psychology Review, 29(8), 674–684.

    PubMed  Google Scholar 

  • Verfaellie, M., Lee, L. O., Lafleche, G., & Spiro, A. (2016). Self-reported sleep disturbance mediates the relationship between PTSD and cognitive outcome in blast-exposed OEF/OIF veterans. Journal of Head Trauma Rehabilitation, 31(5), 309–319.

    PubMed  Google Scholar 

  • Verfaellie, M., & Vasterling, J. J. (2009). Memory in PTSD: A neurocognitive approach. In J. LeDoux, T. Keane, & P. Shiromani (Eds.), Post-traumatic stress disorder (pp. 105–130). New York, New York: Humana Press.

    Google Scholar 

  • Merrit, V. C., Clark, A. L., Crocker, L. D., Sorg, S. F., Werhane, M. L., & Bondi, M.W… Delano- Wood, L. (2018). Repetitive mild traumatic brain injury in military veterans is associated with increased neuropsychological intra-individual variability. Neuropsychologica, 119, 340–348.

  • Wagner, T. H., Harris, K. M., Federman, B., Dai, L., Luna, Y., & Humphreys, K. (2007). Prevalence of substance use disorders among veterans and comparable nonveterans from the national survey of drug use and health. Psychological Services, 4(3), 149–157.

    Google Scholar 

  • Wilson, K. R., Hansen, D. J., & Li, M. (2011). The traumatic stress response in child maltreatment and resultant neuropsychological effects. Aggression and Violent Behaviour, 16(2), 87–97.

    Google Scholar 

  • Wisdom, N. M., Pastorek, N. J., Miller, B. I., Booth, J. E., Romesser, J. M., Linck, J. F., & Sim, A. H. (2013). PTSD and cognitive functioning: Importance of including performance validity testing. The Clinical Neuropsychologist, 28, 128–145.

    PubMed  Google Scholar 

  • Woon, F. L., Farrer, T. J., Braman, C. R., Mabey, J. K., & Hedges, D. W. (2017). A meta-analysis of the relationship between symptom severity of posttraumatic stress disorder and executive function. Cognitive Neuropsychiatry, 22(1), 1–16.

    PubMed  Google Scholar 

  • Yang, J., Guo, J., & Jiang, X. (2017). Executive function in cancer patients with posttraumatic stress disorder. The International Journal of Psychiatry in Medicine, 52(2), 137–146.

    PubMed  Google Scholar 

  • Yehuda, R. (2001). Biology of posttraumatic stress disorder. The Journal of Clinical Psychiatry, 62(Suppl17), 41–46.

    CAS  PubMed  Google Scholar 

  • Yehuda, R., Golier, J. A., Tischler, L., Stavitsky, K., & Harvey, P. D. (2005). Learning and memory in aging combat veterans with PTSD. Journal of Clinical and Experimental Neuropsychology, 27(4), 504–515.

    PubMed  Google Scholar 

  • Young, J. C., Roper, B. L., & Arentsen, T. J. (2016). Validity testing and neuropsychology practice in the VA healthcare system: Results from a recent practitioner survey. The Clinical Neuropsychologist, 30(4), 497–514.

    PubMed  Google Scholar 

  • Zeng, X., Zhang, Y., Kwong, J. S. W., Zhang, C., Li, S., Sun, F., & …Du, L. (2015). The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: A systematic review. Journal of Evidence-Based Medicine, 8(1), 2–10.

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Authors and Affiliations

  1. Department of Psychology, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada

    Kristen Silveira, Mauricio A. Garcia-Barrera & Colette M. Smart

  2. Institute on Aging and Lifelong Health, University of Victoria, Victoria, BC, V8W 2Y2, Canada

    Mauricio A. Garcia-Barrera & Colette M. Smart

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  1. Kristen Silveira
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  2. Mauricio A. Garcia-Barrera
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  3. Colette M. Smart
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Correspondence to Kristen Silveira.

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Silveira, K., Garcia-Barrera, M.A. & Smart, C.M. Neuropsychological Impact of Trauma-Related Mental Illnesses: A Systematic Review of Clinically Meaningful Results. Neuropsychol Rev 30, 310–344 (2020). https://doi.org/10.1007/s11065-020-09444-6

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