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A Systematic Meta-Review of Impulsivity and Compulsivity in Addictive Behaviors

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Abstract

It is well established that poor inhibitory control confers both a vulnerability to, and maintenance of, addictive behaviors across the substance and behavioral spectrums. By comparison, the role of compulsivity in addictive behaviors has received less research focus. The neurocognitive literature to date is vast, and it is unclear whether there are any convincing lines of systematic evidence delineating whether and how aspects of impulsivity and compulsivity are shared and unique across different substance and behavioral addictive disorders. Such information has significant implications for our understanding of underlying mechanisms and clinical implications for assessing and treating neurocognitive deficits across addictions. Here, we conducted a systematic meta-review of the quantitative meta-analyses to date, specifically examining the neurocognitive functions central to impulsive-compulsive behaviors transdiagnostically across addictive behaviors. Out of 1186 empirical studies initially identified, six meta-analyses met inclusion criteria examining alcohol, cannabis, cocaine, MDMA, methamphetamine, opioid and tobacco use, as well as gambling and internet addiction. The pooled findings across the systematic meta-analyses suggest that impulsivity is a core process underpinning both substance and behavioral addictive disorders, although it is not equally implicated across all substances. Compulsivity-related neurocognition, by comparison, is important across alcohol and gambling disorders, but has yet to be examined systematically. The gestalt of findings to date suggests that both impulsivity and compulsivity are core constructs linked to addictive behaviors and may not be solely the secondary sequelae associated with the effects of prolonged substance exposure.

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References

  • Anderson, S. W., Damasio, H., Jones, R. D., & Tranel, D. (1991). Wisconsin card sorting test performance as a measure of frontal lobe damage. Journal of Clinical and Experimental Neuropsychology, 13(6), 909–922.

    Article  CAS  Google Scholar 

  • Assadi, S. M., Yucel, M., & Pantelis, C. (2009). Dopamine modulates neural networks involved in effort-based decision-making. Neuroscience and Biobehavioral Reviews, 33(3), 383–393.

    Article  CAS  Google Scholar 

  • Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nature Neuroscience, 8(11), 1458–1463.

    Article  CAS  Google Scholar 

  • Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50(1-3), 7–15.

    Article  CAS  Google Scholar 

  • Broos, N., Schmaal, L., Wiskerke, J., Kostelijk, L., Lam, T., Stoop, N., … Goudriaan, A. E. (2012). The relationship between impulsive choice and impulsive action: A cross-species translational study. PLoS One, 7(5), e36781.

    Article  CAS  Google Scholar 

  • Burgess, P. W., & Shallice, T. (1996). Response suppression, initiation and strategy use following frontal lobe lesions. Neuropsychologia, 34(4), 263–272.

    Article  CAS  Google Scholar 

  • Carter, A., Hendrikse, J., Lee, N., Yücel, M., Verdejo-Garcia, A., Andrews, Z., & Hall, W. (2016). The neurobiology of “food addiction” and its implications for obesity treatment and policy. Annual Review of Nutrition, 36(1), 105–128.

    Article  CAS  Google Scholar 

  • Chamberlain, S. R., Fineberg, N. A., Blackwell, A. D., Robbins, T. W., & Sahakian, B. J. (2006). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. The American Journal of Psychiatry, 163(7), 1282–1284.

    Article  Google Scholar 

  • Chamberlain, S. R., Stochl, J., Redden, S. A., & Grant, J. E. (2018). Latent traits of impulsivity and compulsivity: Toward dimensional psychiatry. Psychological Medicine, 48(5), 810–821.

  • Chesney, E., Goodwin, G. M., & Fazel, S. (2014). Risks of all-cause and suicide mortality in mental disorders: A meta-review. World Psychiatry, 13(2), 153–160.

    Article  Google Scholar 

  • Chowdhury, N. S., Livesey, E. J., Blaszczynski, A., & Harris, J. A. (2017). Pathological gambling and motor impulsivity: A systematic review with meta-analysis. Journal of Gambling Studies, 33(4), 1213–1239.

    Article  Google Scholar 

  • Comalli, P. E., Wapner, S., & Werner, H. (1962). Interference effects of Stroop color-word test in childhood, adulthood, and aging. The Journal of Genetic Psychology, 100(1), 47–53.

    Article  Google Scholar 

  • Cuthbert, B. N. (2014). The RDoC framework: Facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry, 13(1), 28–35.

    Article  Google Scholar 

  • Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Medicine, 11(1), 126.

    Article  Google Scholar 

  • Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron, 69(4), 680–694.

    Article  CAS  Google Scholar 

  • Dalley, J. W., & Robbins, T. W. (2017). Fractionating impulsivity: Neuropsychiatric implications. Nature Reviews. Neuroscience, 18(3), 158–171.

    Article  CAS  Google Scholar 

  • Daruna, J. H., & Barnes, P. A. (1993). A neurodevelopmental view of impulsivity. In The impulsive client: Theory, research, and treatment (pp. 23–37). Washington, DC, US: American Psychological Association.

    Chapter  Google Scholar 

  • de Wit, H. (2009). Impulsivity as a determinant and consequence of drug use: A review of underlying processes. Addiction Biology, 14(1), 22–31.

    Article  Google Scholar 

  • Denys, D. (2011). Obsessionality & compulsivity: A phenomenology of obsessive-compulsive disorder. Philosophy, Ethics, and Humanities in Medicine : PEHM, 6(1), 3–3.

    Article  Google Scholar 

  • Eagle, D. M., & Robbins, T. W. (2003). Inhibitory control in rats performing a stop-signal reaction-time task: Effects of lesions of the medial striatum and d-amphetamine. Behavioral Neuroscience, 117(6), 1302–1317.

    Article  CAS  Google Scholar 

  • Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J., Gillan, C. M., … Potenza, M. N. (2014). New developments in human neurocognition: Clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectrums, 19(01), 69–89.

    Article  Google Scholar 

  • Francke, A. L., Smit, M. C., de Veer, A. J., & Mistiaen, P. (2008). Factors influencing the implementation of clinical guidelines for health care professionals: A systematic meta-review. BMC Medical Informatics and Decision Making, 8(1), 38.

    Article  Google Scholar 

  • Franken, I. H. A., & van de Wetering, B. J. (2015). Bridging the gap between the neurocognitive lab and the addiction clinic. Addictive Behaviors, 44, 108–114.

    Article  Google Scholar 

  • Franzen, M. D., Paul, D. S. & Price, G. (1990). Alternate form reliability of Trails A, B, C, and D. In Ninth Annual Convention of the National Academy of Neuropsychology: Reno, NY.

  • Gomez, P., Ratcliff, R., & Perea, M. (2007). A model of the go/no-go task. Journal of Experimental Psychology. General, 136(3), 389–413.

    Article  Google Scholar 

  • Goudriaan, A. E., Oosterlaan, J., De Beurs, E., & Van Den Brink, W. (2006). Neurocognitive functions in pathological gambling: A comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101(4), 534–547.

    Article  Google Scholar 

  • Hester, R., Lubman, D. I., & Yücel, M. (2010). The role of executive control in human drug addiction. In D. W. Self & J. K. Staley Gottschalk (Eds.), Behavioral neuroscience of drug addiction (pp. 301–318). Berlin, Heidelberg: Springer Berlin Heidelberg.

    Chapter  Google Scholar 

  • Koob, G. F., & Le Moal, M. (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology, 24(2), 97–129.

    Article  CAS  Google Scholar 

  • Kovacs, I., Richman, M. J., Janka, Z., Maraz, A., & Ando, B. (2017). Decision making measured by the Iowa gambling task in alcohol use disorder and gambling disorder: A systematic review and meta-analysis. Drug and Alcohol Dependence, 181, 152–161.

    Article  Google Scholar 

  • Lee, R. S. C., Dore, G., Juckes, L., De Regt, T., Naismith, S. L., Lagopoulos, J., … Hermens, D. F. (2015). Cognitive dysfunction and functional disability in alcohol dependent adults with or without a comorbid affective disorder. Cognitive Neuropsychiatry, 20(3), 222–231.

    Article  Google Scholar 

  • Lee, R. S. C., Hermens, D. F., Scott, J., Redoblado-Hodge, M. A., Naismith, S. L., Lagopoulos, J., … Hickie, I. B. (2014). A meta-analysis of neuropsychological functioning in first-episode bipolar disorders. Journal of Psychiatric Research, 57, 1–11.

    Article  Google Scholar 

  • Lezak, M. D., Howieson, D. B., Bigler, E. D., & Tranel, D. (2012). Neuropsychological assessment. New York: Oxford University Press.

    Google Scholar 

  • Lipszyc, J., & Schachar, R. (2010). Inhibitory control and psychopathology: A meta-analysis of studies using the stop signal task. Journal of the International Neuropsychological Society, 16(06), 1064–1076.

    Article  Google Scholar 

  • Lubman, D. I., Cheetham, A., & Yücel, M. (2015). Cannabis and adolescent brain development. Pharmacology & Therapeutics, 148, 1–16.

    Article  CAS  Google Scholar 

  • Lubman, D. I., Yücel, M., & Pantelis, C. (2004). Addiction, a condition of compulsive behaviour? Neuroimaging and neuropsychological evidence of inhibitory dysregulation. Addiction, 99(12), 1491–1502.

    Article  Google Scholar 

  • Marhe, R., & Franken, I. (2014). Error-related brain activity as a biomarker for cocaine relapse. Neuropsychopharmacology Reviews, 39(1), 241.

    Article  Google Scholar 

  • Marhe, R., Luijten, M., van de Wetering, B. J., Smits, M., & Franken, I. H. A. (2013). Individual differences in anterior cingulate activation associated with attentional bias predict cocaine use after treatment. Neuropsychopharmacology, 38(6), 1085–1093.

    Article  Google Scholar 

  • Newman, J. P., Patterson, C. M., & Kosson, D. S. (1987). Response perseveration in psychopaths. Journal of Abnormal Psychology, 96(2), 145–148.

    Article  CAS  Google Scholar 

  • O'Brien, C. (2011). Addiction and dependence in DSM-V. Addiction, 106(5), 866–867.

    Article  Google Scholar 

  • Perlis, R. H. (2011). Translating biomarkers to clinical practice. Molecular Psychiatry, 16(11), 1076–1087.

    Article  CAS  Google Scholar 

  • Prochazkova, L., Parkes, L., Dawson, A., Youssef, G., Ferreira, G. M., Lorenzetti, V., … Yücel, M. (2018). Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder. CNS Spectrums, 23(1), 51–58.

  • Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012). Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry. Trends in Cognitive Sciences, 16(1), 81–91.

    Article  Google Scholar 

  • Sahakian, B. J., & Owen, A. M. (1992). Computerized assessment in neuropsychiatry using CANTAB: Discussion paper. Journal of the Royal Society of Medicine, 85, 399–402.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Smith, J. L., Mattick, R. P., Jamadar, S. D., & Iredale, J. M. (2014). Deficits in behavioural inhibition in substance abuse and addiction: A meta-analysis. Drug and Alcohol Dependence, 145, 1–33.

    Article  Google Scholar 

  • Stavro, K., Pelletier, J., & Potvin, S. (2013). Widespread and sustained cognitive deficits in alcoholism: A meta-analysis. Addiction Biology, 18(2), 203–213.

    Article  Google Scholar 

  • Stephan, R. A., Alhassoon, O. M., Allen, K. E., Wollman, S. C., Hall, M., Thomas, W. J., … Grant, I. (2017). Meta-analyses of clinical neuropsychological tests of executive dysfunction and impulsivity in alcohol use disorder. The American Journal of Drug and Alcohol Abuse, 43(1), 24–43.

    Article  Google Scholar 

  • Sussman, S., & Sussman, A. N. (2011). Considering the definition of addiction. International Journal of Environmental Research and Public Health, 8(10), 4025–4038.

    Article  Google Scholar 

  • Torregrossa, M. M., Xie, M., & Taylor, J. R. (2012). Chronic corticosterone exposure during adolescence reduces impulsive action but increases impulsive choice and sensitivity to yohimbine in male Sprague-Dawley rats. Neuropsychopharmacology, 37(7), 1656–1670.

    Article  CAS  Google Scholar 

  • van Timmeren, T., Daams, J. G., van Holst, R. J., & Goudriaan, A. E. (2018). Compulsivity-related neurocognitive performance deficits in gambling disorder: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 84, 204–217.

    Article  Google Scholar 

  • Verdejo-Garcia, A. (2016). Cognitive training for substance use disorders: Neuroscientific mechanisms. Neuroscience and Biobehavioral Reviews, 68, 270–281.

    Article  Google Scholar 

  • Verdejo-Garcia, A., Lawrence, A. J., & Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies. Neuroscience and Biobehavioral Reviews, 32(4), 777–810.

    Article  Google Scholar 

  • Verdejo-Garcia, A., Lubman, D. I., Schwerk, A., Roffel, K., Vilar-Lopez, R., Mackenzie, T., & Yucel, M. (2012). Effect of craving induction on inhibitory control in opiate dependence. Psychopharmacology, 219(2), 519–526.

    Article  CAS  Google Scholar 

  • Whelan, R., Watts, R., Orr, C. A., Althoff, R. R., Artiges, E., Banaschewski, T., … Garavan, H. (2014). Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature, 512(7513), 185–189.

    Article  CAS  Google Scholar 

  • Wiers, R. W. (2018). Cognitive training in addiction: Does it have clinical potential? Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 101–102.

    Google Scholar 

  • Yücel, M., & Fontenelle, L. F. (2012). Compulsivity as an endophenotype: The search for a hazy moving target. Addiction, 107(10), 1735–1736.

    Article  Google Scholar 

  • Yucel, M., Fornito, A., Youssef, G., Dwyer, D., Whittle, S., Wood, S. J., … Allen, N. B. (2012). Inhibitory control in young adolescents: The role of sex, intelligence, and temperament. Neuropsychology, 26, 347–356.

    Article  Google Scholar 

  • Yucel, M., Oldenhof, E., Ahmed, S. H., Belin, D., Billieux, J., Bowden-Jones, H., Carter, A., Chamberlain, S. R., Clark, L., Connor, J., Daglish, M., Dom, G., Dannon, P., Duka, T., Fernandez-Serrano, M. J., Field, M., Franken, I., Goldstein, R. Z., Gonzalez, R., Goudriaan, A. E., Grant, J. E., Gullo, M. J., Hester, R., Hodgins, D. C., Le Foll, B., Lee, R. S. C., Lingford-Hughes, A., Lorenzetti, V., Moeller, S. J., Munafo, M. R., Odlaug, B., Potenza, M. N., Segrave, R., Sjoerds, Z., Solowij, N., van den Brink, W., van Holst, R. J., Voon, V., Wiers, R., Fontenelle, L. F. & Verdejo-Garcia, A. (2018). A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study. Addiction. https://doi.org/10.1111/add.14424.

  • Zalesky, A., Solowij, N., Yucel, M., Lubman, D. I., Takagi, M., Harding, I. H., … Seal, M. (2012). Effect of long-term cannabis use on axonal fibre connectivity. Brain, 135(7), 2245–2255.

    Article  Google Scholar 

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Authors and Affiliations

  1. Brain and Mental Health Laboratory, Monash University, Clayton, Australia

    Rico S. C. Lee

  2. Monash Biomedical Imaging, 770 Blackburn Rd, Clayton, VIC, 3800, Australia

    Rico S. C. Lee

  3. Erasmus University, Rotterdam, The Netherlands

    Sylco Hoppenbrouwers & Ingmar Franken

  4. Thalamus, Centre for Neuropsychiatry and Behavioural Neurology, Wolfheze, The Netherlands

    Sylco Hoppenbrouwers

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  1. Rico S. C. Lee
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Lee, R.S.C., Hoppenbrouwers, S. & Franken, I. A Systematic Meta-Review of Impulsivity and Compulsivity in Addictive Behaviors. Neuropsychol Rev 29, 14–26 (2019). https://doi.org/10.1007/s11065-019-09402-x

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