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Remote Memory Function and Dysfunction in Korsakoff’s Syndrome

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Abstract

Korsakoff’s syndrome (KS) is a pervasive disorder of memory characterized by both anterograde and retrograde amnesia. Although retrograde memory impairment in KS has been less frequently studied, the status of remote memory in KS has been tested across a number of different tasks that measure knowledge of public information (e.g., famous faces/news events), general semantic information (e.g., vocabulary words), personal semantic information (e.g., facts about oneself), and autobiographical events (e.g., events from one’s personal past). In each of these domains, Korsakoff patients demonstrate remote memory impairments that can extend back many years or decades. In addition, a majority of studies report that the extensive remote memory impairment in KS is temporally graded, with relative preservation of memories from childhood and early adulthood. The current paper reviews published experimental studies of remote memory in KS, with particular attention paid to (a) the selectivity of the deficit with respect to the age of the memory and (b) the relationship of memory impairment to underlying neuropathology. We discuss the significance of the reported pattern and extent of remote memory impairment with respect to theories about the nature of the underlying cognitive deficits in KS.

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References

  • Albert, M. S., Butters, N., & Levin, J. (1979). Temporal gradients in the retrograde amnesia of patients with alcoholic Korsakoff's disease. Archives of Neurology, 36(4), 211–216.

    Article  PubMed  CAS  Google Scholar 

  • Albert, M. S., Butters, N., & Brandt, J. (1981). Patterns of remote memory in amnesic and demented patients. Archives of Neurology, 38(8), 495–500.

    Article  PubMed  CAS  Google Scholar 

  • Benson, D. F., Djenderedjian, A., Miller, B. L., Pachana, N. A., Chang, L., Itti, L., et al. (1996). Neural basis of confabulation. Neurology, 46(5), 1239–1243.

    Article  PubMed  CAS  Google Scholar 

  • Borsutzky, S., Fujiwara, E., Brand, M., & Markowitsch, H. J. (2008). Confabulations in alcoholic Korsakoff patients. Neuropsychologia, 46(13), 3133–3143.

    Article  PubMed  Google Scholar 

  • Butters, N. (1984). Alcoholic Korsakoff’s syndrome: an update. Seminars in Neurology, 4, 229–247.

    Google Scholar 

  • Butters, N., & Albert, M. S. (1982). Processess underlying failures to recall remote events. In L. S. Cermak (Ed.), Human memory and amnesia (pp. 257–303). Hillsdale, N.J.: Erlbaum.

    Google Scholar 

  • Butters, N., & Cermak, L. S. (1986). A case study of the forgetting of autobiographical knowledge: implications for the study of retrograde amnesia. In D. C. Rubin (Ed.), Autobiographical memory. Cambridge: Cambridge University Press.

  • Cermak, L. S., Butters, N., & Goodglass, H. (1971). The extent of memory loss in Korsakoff patients. Neuropsychologia, 9(3), 307–315.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, N. J., & Squire, L. R. (1981). Retrograde amnesia and remote memory impairment. Neuropsychologia, 19(3), 337–356.

    Article  PubMed  CAS  Google Scholar 

  • Conway, M. A., Turk, D. J., Miller, S. L., Logan, J., Nebes, R. D., Meltzer, C. C., et al. (1999). A positron emission tomography (PET) study of autobiographical memory retrieval. Memory, 7(5–6), 679–702.

    Article  PubMed  CAS  Google Scholar 

  • Corkin, S., Cohen, N. J., Sullivan, E. V., Clegg, R. A., Rosen, T. J., & Ackerman, R. H. (1985). Analyses of global memory impairments of different etiologies. Annals of the New York Academy of Sciences, 444, 10–40.

    Article  PubMed  CAS  Google Scholar 

  • Crovitz, H. F., & Schiffman, H. (1974). Frequency of episodic memories as a function of their age. Bulletin of the Psychonomic Society, 4, 517–518.

    Google Scholar 

  • Eustache, F., Desgranges, B., Aupee, A. M., Guillery, B., & Baron, J. C. (2000). Functional neuroanatomy of amnesia: positron emission tomography studies. Microscopy Research and Technique, 51(1), 94–100.

    Article  PubMed  CAS  Google Scholar 

  • Fama, R., Marsh, L., & Sullivan, E. V. (2004). Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome. Journal of International Neuropsychological Society, 10(3), 427–441.

    Article  Google Scholar 

  • Gilboa, A., & Verfaellie, M. (2010). Telling it like it isn't: the cognitive neuroscience of confabulation. Journal of International Neuropsychological Society, 16(6), 961–966.

    Article  Google Scholar 

  • Greene, J. D., Hodges, J. R., & Baddeley, A. D. (1995). Autobiographical memory and executive function in early dementia of Alzheimer type. Neuropsychologia, 33(12), 1647–1670.

    Article  PubMed  CAS  Google Scholar 

  • Heiss, W. D., Pawlik, G., Holthoff, V., Kessler, J., & Szelies, B. (1992). PET correlates of normal and impaired memory functions. Cerebrovascular and Brain Metabolism Reviews, 4(1), 1–27.

    PubMed  CAS  Google Scholar 

  • Jernigan, T. L., Schafer, K., Butters, N., & Cermak, L. S. (1991). Magnetic resonance imaging of alcoholic Korsakoff patients. Neuropsychopharmacology, 4(3), 175–186.

    PubMed  CAS  Google Scholar 

  • Kan, I. P., Larocque, K. F., Lafleche, G., Coslett, H. B., & Verfaellie, M. (2010). Memory monitoring failure in confabulation: evidence from the semantic illusion paradigm. Journal of International Neuropsychological Society, 16(6), 1006–1017.

    Article  Google Scholar 

  • Kessels, R. P., Kortrijk, H. E., Wester, A. J., & Nys, G. M. (2008). Confabulation behavior and false memories in Korsakoff's syndrome: role of source memory and executive functioning. Psychiatry and Clinical Neurosciences, 62(2), 220–225.

    Article  PubMed  Google Scholar 

  • Kopelman, M. D. (1989). Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients. Neuropsychologia, 27(4), 437–460.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, M. D. (1991). Frontal dysfunction and memory deficits in the alcoholic Korsakoff syndrome and Alzheimer-type dementia. Brain, 114(Pt 1A), 117–137.

    PubMed  Google Scholar 

  • Kopelman, M. D. (1993). The neuropsychology of remote memory. In H. Spinnler & F. Boller (Eds.), Handbook of neuropsychology, vol. 8 (pp. 215–238). Amsterdam: Elsevier Sceince Publishers.

    Google Scholar 

  • Kopelman, M. D. (1995). The Korsakoff syndrome. The British Journal of Psychiatry, 166(2), 154–173.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, M. D. (2002). Disorders of memory. Brain, 125(Pt 10), 2152–2190.

    Article  PubMed  Google Scholar 

  • Kopelman, M. D., Wilson, B. A., & Baddeley, A. D. (1989). The autobiographical memory interview: a new assessment of autobiographical and personal semantic memory in amnesic patients. Journal of Clinical and Experimental Neuropsychology, 11(5), 724–744.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, M. D., Stanhope, N., & Kingsley, D. (1999). Retrograde amnesia in patients with diencephalic, temporal lobe or frontal lesions. Neuropsychologia, 37(8), 939–958.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, M. D., Lasserson, D., Kingsley, D. R., Bello, F., Rush, C., Stanhope, N., et al. (2003). Retrograde amnesia and the volume of critical brain structures. Hippocampus, 13(8), 879–891.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, M. D., Bright, P., Fulker, H., Hinton, N., Morrison, A., & Verfaellie, M. (2009). Remote semantic memory in patients with Korsakoff's syndrome and herpes encephalitis. Neuropsychology, 23(2), 144–157.

    Article  PubMed  Google Scholar 

  • Levine, B., Svoboda, E., Hay, J. F., Winocur, G., & Moscovitch, M. (2002). Aging and autobiographical memory: dissociating episodic from semantic retrieval. Psychology and Aging, 17(4), 677–689.

    Article  PubMed  Google Scholar 

  • MacKinnon, D. F., & Squire, L. R. (1989). Autobiographical memory and amnesia. Psychobiology, 17, 247–256.

    Google Scholar 

  • Mair, W. G., Warrington, E. K., & Weiskrantz, L. (1979). Memory disorder in Korsakoff's psychosis: a neuropathological and neuropsychological investigation of two cases. Brain, 102(4), 749–783.

    Article  PubMed  CAS  Google Scholar 

  • Marslen-Wilson, W. D., & Teuber, H. L. (1975). Memory for remote events in anterograde amnesia: recognition of public figures from newsphotographs. Neuropsychologia, 13(3), 353–364.

    Article  PubMed  CAS  Google Scholar 

  • Meudell, P. R., Northen, B., Snowden, J. S., & Neary, D. (1980). Long term memory for famous voices in amnesic and normal subjects. Neuropsychologia, 18(2), 133–139.

    Article  PubMed  CAS  Google Scholar 

  • Paller, K. A., Acharya, A., Richardson, B., Plaisant, O., Shimamura, A. P., Reed, B. R., et al. (1997). Functional neuroimaging of cortical dysfunction in alcoholic Korsakoff's Syndrome. Journal of Cognitive Neuroscience, 9(2), 277–293.

    Article  Google Scholar 

  • Parkin, A. J. (1991). The relationship between anterograde and retrograde amnesia in alcoholic Wernicke-Korsakoff syndrome. Psychological Medicine, 21(1), 11–14.

    Article  PubMed  CAS  Google Scholar 

  • Parkin, A. J., Montaldi, D., Leng, N. R., & Hunkin, N. M. (1990). Contextual cueing effects in the remote memory of alcoholic Korsakoff patients and normal subjects. The Quarterly Journal of Experimental Psychology. A, 42(3), 585–596.

    Article  CAS  Google Scholar 

  • Ryan, L., Nadel, L., Keil, K., Putnam, K., Schnyer, D., Trouard, T., et al. (2001). Hippocampal complex and retrieval of recent and very remote autobiographical memories: evidence from functional magnetic resonance imaging in neurologically intact people. Hippocampus, 11(6), 707–714.

    Article  PubMed  CAS  Google Scholar 

  • Sanders, H. I., & Warrington, E. K. (1971). Memory for remote events in amnesic patients. Brain, 94(4), 661–668.

    Article  PubMed  CAS  Google Scholar 

  • Seltzer, B., & Benson, D. F. (1974). The temporal pattern of retrograde amnesia in Korsakoff's disease. Neurology, 24(6), 527–530.

    Article  PubMed  CAS  Google Scholar 

  • Shimamura, A. P., & Squire, L. R. (1986). Korsakoff's syndrome: a study of the relation between anterograde amnesia and remote memory impairment. Behavioral Neuroscience, 100(2), 165–170.

    Article  PubMed  CAS  Google Scholar 

  • Shimamura, A. P., Jernigan, T. L., & Squire, L. R. (1988). Korsakoff's syndrome: radiological (CT) findings and neuropsychological correlates. Journal of Neuroscience, 8(11), 4400–4410.

    PubMed  CAS  Google Scholar 

  • Squire, L. R. (1982). Comparisons between forms of amnesia: some deficits are unique to Korsakoff's syndrome. Journal of Experimental Psychology: Learning, Memory, and Cognition, 8(6), 560–571.

    Article  PubMed  CAS  Google Scholar 

  • Squire, L. R., & Cohen, N. J. (1982). Remote memory, retrograde amnesia, and the neuropsychology of memory. In L. S. Cermak (Ed.), Human memory and amnesia (vol. 275–303). Hillsdale, NJ: Lawrence Erlbaum Associates.

    Google Scholar 

  • Sullivan, E. V., & Marsh, L. (2003). Hippocampal volume deficits in alcoholic Korsakoff's syndrome. Neurology, 61(12), 1716–1719.

    Article  PubMed  Google Scholar 

  • Sullivan, E. V., & Pfefferbaum, A. (2009). Neuroimaging of the Wernicke-Korsakoff syndrome. Alcohol and Alcoholism, 44(2), 155–165.

    Article  PubMed  Google Scholar 

  • Van Damme, I., & d'Ydewalle, G. (2010). Confabulation versus experimentally induced false memories in Korsakoff patients. Journal of Neuropsychology, 4(Pt 2), 211–230.

    Article  PubMed  Google Scholar 

  • Verfaellie, M. (2003). Korsakoff and related nutritional disorders of the nervous system. In T. E. Feinberg & M. J. Farah (Eds.), Behavioral neurology and neuropsychology (pp. 639–650). New York: McGraw Hill.

    Google Scholar 

  • Verfaellie, M., Reiss, L., & Roth, H. L. (1995). Knowledge of New English vocabulary in amnesia: an examination of premorbidly acquired semantic memory. Journal of International Neuropsychological Society, 1(5), 443–453.

    Article  CAS  Google Scholar 

  • Visser, P. J., Krabbendam, L., Verhey, F. R., Hofman, P. A., Verhoeven, W. M., Tuinier, S., et al. (1999). Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome. Journal of Neurology, Neurosurgery, and Psychiatry, 67(6), 774–778.

    Article  PubMed  CAS  Google Scholar 

  • Warrington, E. K., & Weiskrantz, L. (1973). An analysis of short-term and long-term memory defects in man. In J. A. Deutsch (Ed.), The physiological basis of memory (pp. 365–395). New York: Academic.

    Google Scholar 

  • Warrington, E. K., & Weiskrantz, L. (1978). Further analysis of the prior learning effect in amnesic patients. Neuropsychologia, 16(2), 169–177.

    Article  PubMed  CAS  Google Scholar 

  • Westmacott, R., & Moscovitch, M. (2003). The contribution of autobiographical significance to semantic memory. Memory and Cognition, 31(5), 761–774.

    Article  Google Scholar 

  • Zola-Morgan, S., Cohen, N. J., & Squire, L. R. (1983). Recall of remote episodic memory in amnesia. Neuropsychologia, 21(5), 487–500.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by VA Clinical Science Research and Development Service and NIH-NINDS National Research Service award F32NS073212.

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  1. Boston University School of Medicine, Boston, MA, USA

    Elizabeth Race & Mieke Verfaellie

  2. Memory Disorders Research Center, Boston VA Healthcare System, 150 S. Huntington Avenue (151-A), Boston, MA, 02130, USA

    Elizabeth Race & Mieke Verfaellie

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  1. Elizabeth Race
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Correspondence to Mieke Verfaellie.

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Race, E., Verfaellie, M. Remote Memory Function and Dysfunction in Korsakoff’s Syndrome. Neuropsychol Rev 22, 105–116 (2012). https://doi.org/10.1007/s11065-012-9197-y

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