Functional Neuroimaging in the Examination of Effects of Prenatal Alcohol Exposure
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Functional neuroimaging offers the opportunity to understand the effect of prenatal alcohol exposure on the activities of the brain as well as providing a window into the relationship between neural activation and the behavioral outcomes that have been described in affected individuals. Several different methodologies have been used to examine the neurophysiological signal changes associated with different brain functions in prenatally exposed individuals and those diagnosed with fetal alcohol syndrome (FAS) or other fetal alcohol spectrum disorders (FASD). These include electroencephalography (EEG), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI). These studies demonstrate that it is feasible to use these technologies with this clinical population and that the damage to the central nervous system associated with prenatal alcohol exposure has widespread functional implications; however, currently, the literature in these areas is limited and unsystematic. Functional MRI with this clinical population has just begun to explore the implications of prenatal alcohol exposure with the first paper published in 2005. Other methodologies are similarly limited in scope. Nonetheless, these functional neuroimaging studies suggest that prenatal alcohol exposure, or a diagnosis of FAS, may lead to restrictions in neural efficiency or a global decrement in processing resources.
KeywordsPrenatal alcohol exposure EEG PET SPECT fMRI Review
- Astley, S. J., Aylward, E. H., Olson, H. C., Kerns, K., Brooks, A., Coggins, T. E., et al. (2009). Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fatal alcohol spectrum disorders. Journal of Neurodevelopmental Disorders, 1(1), 61–80.PubMedCrossRefGoogle Scholar
- Burden, M. J., Andrew, C., Saint-Amour, D., Meintjes, E. M., Molteno, C. D., Hoyme, H. E., et al. (2009). The effects of fetal alcohol syndrome on response execution and inhibition: an event-related potential study. Alcoholism: Clinical and Experimental Research, 33(11), 1994–2004.CrossRefGoogle Scholar
- Burden, M. J., Jacobson, J. L., Westerlund, A., Lundahl, L. H., Morrison, A., Dodge, N. C., et al. (2010). An event-related potential study of response inhibition in ADHD with and without prenatal alcohol exposure. Alcoholism: Clinical and Experimental Research, 34(4), 617–627.CrossRefGoogle Scholar
- Burden, M. J., Westerlund, A., Muckle, G., Dodge, N., Dewailly, E., Nelson, C. A., et al. (2011). The effects of maternal binge drinking during pregnancy on neural correlates of response inhibition and memory in childhood. Alcoholism: Clinical and Experimental Research, 35(1), 69–82.CrossRefGoogle Scholar
- Chen, X., Coles, C. D., Lynch, M. E., & Hu, X. (2011). Understanding specific effects of prenatal alcohol exposure on brain structure in young adults. Human Bran Mapping, In press.Google Scholar
- D’Angiulli, A., Grunau, P., Maggi, S., & Herdman, A. (2006). Electroencephalographic correlates of prenatal exposure to alcohol in infants and children: a review of findings and implications for neurocognitive development. Alcohol Research & Health, 40(2), 127–133.Google Scholar
- Fabiani, M., Gratton, G., & Coles, M. G. H. (2000). Event-related brain potentials methods, theory, and applications. In J. T. Cacioppo, L. G. Tassinary, & G. G. Berntson (Eds.), Handbook of psychophysiology (pp. 53–84). Cambridge: Cambridge University Press.Google Scholar
- Ioffe, S., Childiaeva, R., & Chernick, V. (1984). Prolonged effects of maternal alcohol ingestion on the neonatal electroencephalogram. Pediatrics, 74(3), 330–335.Google Scholar
- Kable, J. A., & Coles, C. D. (2004). Teratology of alcohol: Implications for school settings. In R. T. Brown (Ed.), Handbook of pediatric psychology in school settings. Mahwah: Lawrence Erlbaum Associates Publishers.Google Scholar
- Li, Z., Santhanam, P., Coles, C. D., Lynch, M. E., Hamann, S., Peltier, S., et al. (2010). Increased default mode activity in adolescents prenatally exposed to cocaine. Human Bran Mapping, In press, doi:10.1002/hbm.21059.
- Liddle, E. B., Hollis, C., Batty, M. J., Groom, M. J., Totman, J. J., Liotti, M., et al. (2010). Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate. Journal of Child Psychology and Psychiatry, In press, doi:10.1111/j.1469-7610.2010.02333.x.
- Malisza, K. L., Allman, A.-A., Shiloff, D., Jakobson, L., Longstaffe, S., & Chudley, A. E. (2005). Evaluation of spatial working memory function in children and adults with fetal alcohol spectrum disorders: a functional magnetic resonance imaging study. Pediatric Research, 58, 1150–1157.PubMedCrossRefGoogle Scholar
- Meintjes, E. M., Jacobson, J. L., Molteno, C. D., Gatenby, J. C., Warton, C., Cannistraci, C. J., et al. (2010). An fMRI study of number processing in children with fetal alcohol syndrome. Alcoholism: Clinical and Experimental Research, 34(8), 1450–1464.Google Scholar
- O’Hare, E. D., Lu, L. H., Houston, S. M., Bookheimer, S. Y., Mattson, S. N., O’Connor, M. J., et al. (2009). Altered frontal-parietal functioning during verbal working memory in children and adolescents with heavy prenatal alcohol exposure. Human Brain Mapping, 30, 3200–3208.PubMedCrossRefGoogle Scholar
- O’Malley, K. D., & Nanson, J. (2002). Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. Canadian Journal of Psychiatry, 47(4), 349–354.Google Scholar
- Riikonen, R. S., Nokelainen, P., Valkonen, K., Kolehmainen, A. I., Kumpulainen, K. I., Könönen, M., et al. (2005). Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry. Biological Psychiatry, 57, 1565–1572.PubMedCrossRefGoogle Scholar
- Wernick, M. N., & Aarsvold, J. N. (2004). Emission tomography: The fundamentals of PET and SPECT. San Diego: Elsevier Academic Press.Google Scholar