Abstract
As Norman Geschwind asserted in 1965, syndromes resulting from white matter lesions could produce deficits in higher-order functions and “disconnexion” or the interruption of connection between gray matter regions could be as disruptive as trauma to those regions per se. The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white matter fiber integrity in health and disease, has served to strengthen Geschwind’s proposal. Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.
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All authors were involved in drafting the article or revising it critically, and they read and approved the final version of the manuscript. None of the authors has any involvement, financial or otherwise, that might potentially bias their work.
Support for this work was obtained from NIAAA grants AA012388, AA010723, AA017168, AA017923 and NIA grant AG019717.
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Chanraud, S., Zahr, N., Sullivan, E.V. et al. MR Diffusion Tensor Imaging: A Window into White Matter Integrity of the Working Brain. Neuropsychol Rev 20, 209–225 (2010). https://doi.org/10.1007/s11065-010-9129-7
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DOI: https://doi.org/10.1007/s11065-010-9129-7