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White Matter: Organization and Functional Relevance

Neuropsychology Review volume 20, pages 158–173 (2010)Cite this article

Abstract

Norman Geschwind’s landmark paper in 1965, “Disconnexion Syndromes in Animals and Man,” inspired a generation of investigators to consider the effects of focal brain lesions disrupting higher brain functions. Although Geschwind viewed disconnection as resulting from either white or gray matter lesions, his signature article drew upon the insights of 19th century neurologists and firmly established white matter within the vocabulary of behavioral neurology, neuropsychology, and cognitive neuroscience. This influence, and the advent of sensitive neuroimaging techniques later in the 20th century, led to white matter gradually gaining more attention as an essential component of distributed neural networks subserving cognition and emotion. Today, whereas focal white matter lesions remain central to the pathogenesis of classic neurobehavioral syndromes, diffuse white matter involvement is regarded as increasingly relevant to a wide variety of dementia syndromes and a host of neuropsychiatric disorders as well. In parallel, better understanding of the neurobiology of brain white matter at all ages has been achieved. While much remains to be explored, a general conceptual formulation is that white matter supports information transfer to complement the information processing carried out by gray matter. As knowledge of the organization and functional relevance of white matter continues to advance, improved understanding of the role of myelinated tracts in higher function can be anticipated, and with it many clinical benefits.

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References

  • Absher, J. R., & Benson, D. F. (1993). Disconnection syndromes: as overview of Geschwind’s contributions. Neurology, 43, 862–867.

    CAS  PubMed  Google Scholar 

  • Adams, R. D., & Kubik, C. S. (1944). Subacute degeneration of the brain in pernicious anemia. N Engl J Med, 231, 1–9.

    Article  Google Scholar 

  • Adams, R. D., Fisher, C. M., Hakim, S., et al. (1965). Symptomatic occult hydrocephalus with “normal” cerebrospinal-fluid pressure. N Engl J Med, 273, 117–126.

    CAS  PubMed  Google Scholar 

  • Adams, J. H., Graham, D. I., & Jennett, B. (2000). The neuropathology of the vegetative state after an acute brain insult. Brain, 123, 1327–1338.

    PubMed  Google Scholar 

  • Alexander, M. P. (1995). Mild traumatic brain injury: pathophysiology, natural history, and clinical management. Neurology, 45, 1252–1260.

    Google Scholar 

  • Aralasmak, A., Ulmer, J. L., Kocak, M., et al. (2006). Association, commissural, and projection pathways and their functional deficit reported in literature. J Comput Assist Tomogr, 30, 695–715.

    PubMed  Google Scholar 

  • Austin, J., Armstrong, D., Fouch, S., et al. (1968). Metachromatic leukodystrophy (MLD). VIII. MLD in adults: diagnosis and pathogenesis. Arch Neurol, 18, 225–240.

    CAS  PubMed  Google Scholar 

  • Babikian, V., & Ropper, A. H. (1987). Binswanger’s disease: a review. Stroke, 18, 2–12.

    CAS  PubMed  Google Scholar 

  • Bandettini, P. (2009). What’s new in neuroimaging methods? Ann NY Acad Sci, 1156, 260–293.

    PubMed  Google Scholar 

  • Bartzokis, G. (2005). Brain myelination in prevalent neuropsychiatric developmental disorders: primary and comorbid addiction. Adolesc Psychiatry, 29, 55–96.

    PubMed  Google Scholar 

  • Bartzokis, G. (2009). Alzheimer’s Disease as homeostatic responses to age-related myelin breakdown. Neurobiol Aging, Sep 21 [Epub ahead of print].

  • Bartzokis, G., Beckson, M., Lu, P. H., et al. (2001). Age-related changes in frontal and temporal lobe volumes in men. Arch Gen Psychiatry, 58, 461–465.

    CAS  PubMed  Google Scholar 

  • Bartzokis, G., Lu, P. H., Tingus, K., et al. (2008). Lifespan trajectory of myelin integrity and maximum motor speed. Neurobiol Aging, Oct 15 [Epub ahead of print].

  • Basser, P. J., & Jones, D. K. (2002). Diffusion-tensor MRI: theory, experimental design and data analysis-technical review. NMR Biomed, 15, 457–467.

    Google Scholar 

  • Baumann, N., & Pham-Dinh, D. (2001). Biology of oligodendrocyte and myelin in the mammalian nervous system. Physiol Rev, 81, 871–927.

    CAS  PubMed  Google Scholar 

  • Bech, R. A., Juhler, M., Waldemar, G., et al. (1997). Frontal brain and leptomeningeal biopsy specimens correlated with cerebrospinal fluid outflow resistance and B-wave activity in patients suspected of normal-pressure hydrocephalus. Neurosurgery, 40, 497–502.

    CAS  PubMed  Google Scholar 

  • Benes, F. M., Turtle, M., Khan, Y., & Farol, P. (1994). Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch Gen Psychiatry, 51, 477–484.

    CAS  PubMed  Google Scholar 

  • Bengtsson, S. I., Nagy, Z., Skare, S., et al. (2005). Extensive piano practicing has regionally specific effects on white matter development. Nat Neurosci, 8, 1148–1150.

    CAS  PubMed  Google Scholar 

  • Bennaroch, E. F. (2009). Oligodendrocytes. Susceptibility to injury and involvement in neurologic disease. Neurology, 72, 1779–1785.

    Google Scholar 

  • Birren, J. E., & Fisher, L. M. (1995). Aging and speed of behavior: possible consequences for psychological functioning. Annu Rev Psychol, 46, 329–353.

    CAS  PubMed  Google Scholar 

  • Boerner, R. J., & Kapfhammer, H. P. (1999). Psychopathological changes and cognitive impairment in encephalomyelitis disseminata. Eur Arch Clin Neurosci, 249, 96–102.

    CAS  Google Scholar 

  • Boissé, L., Gill, J., & Power, C. (2008). HIV infection of the central nervous system: clinical features and neuropathogenesis. Neurol Clin, 26, 739–819.

    Google Scholar 

  • Canoll, P., & Goldman, J. E. (2008). The interface between glial progenitors and gliomas. Acta Neuropathol, 116, 465–477.

    PubMed  Google Scholar 

  • Caplan, L. R. (1995). Binswanger’s disease—revisited. Neurology, 45, 626–633.

    CAS  PubMed  Google Scholar 

  • Catani, M. (2006). Diffusion tensor magnetic resonance imaging tractography in cognitive disorders. Curr Opin Neurol, 19, 599–606.

    PubMed  Google Scholar 

  • Catani, M., & Ffytche, D. H. (2005). The rises and falls of disconnection syndromes. Brain, 128, 2224–2239.

    PubMed  Google Scholar 

  • Catani, M., Jones, D. K., & Ffytche, D. H. (2005). Perisylvian language networks of the human brain. Ann Neurol, 57, 8–16.

    PubMed  Google Scholar 

  • Charcot, J. M. (1877). Lectures on the diseases of the nervous system delivered at La Salpêtrière. London: New Sydenham Society.

    Google Scholar 

  • Chatterjee, A., Yapundich, R., Palmer, C. A., et al. (1996). Leukoencephalopathy associated with cobalamin deficiency. Neurology, 46, 832–834.

    CAS  PubMed  Google Scholar 

  • Chui, H. (2007). Subcortical ischemic vascular dementia. Neurol Clin, 25, 717–740.

    PubMed  Google Scholar 

  • Cummings, J. L. (Ed.). (1990). Subcortical dementia. New York: Oxford University Press.

    Google Scholar 

  • Cummings, J. L., & Benson, D. F. (1984). Subcortical dementia. Review of an emerging concept. Arch Neurol, 41, 874–9.

    CAS  PubMed  Google Scholar 

  • Davatzikos, C., & Resnick, S. M. (2002). Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging. Cerebral Cortex, 12, 767–771.

    PubMed  Google Scholar 

  • Del Bigio, M. R. (1993). Neuropathological changes caused by hydrocephalus. Acta Neuropathol, 85, 573–585.

    PubMed  Google Scholar 

  • Del Bigio, M. R., da Silva, M. C., Drake, J. M., & Tuor, U. I. (1994). Acute and chronic cerebral white matter damage in neonatal hydrocephalus. Can J Neurol Sci, 21, 299–305.

    PubMed  Google Scholar 

  • Earnest, M. P., Fahn, S., Karp, J. H., & Rowland, L. P. (1974). Normal pressure hydrocephalus and hypertensive cerebrovascular disease. Arch Neurol, 31, 262–266.

    CAS  PubMed  Google Scholar 

  • Fatterpekar, G. M., Naidich, T. P., Delma, B. N., et al. (2002). Cytoarchitecture of the human cerebral cortex: MR spectroscopy of excised specimens at 9.4 T. AJNR, 23, 1313–1321.

    PubMed  Google Scholar 

  • Fields, R. D. (2008). White matter in learning, cognition and psychiatric disorders. Trends Neurosci, 31, 361–370.

    CAS  PubMed  Google Scholar 

  • Filley, C. M. (1998). The behavioral neurology of cerebral white matter. Neurology, 50, 1535–1540.

    CAS  PubMed  Google Scholar 

  • Filley, C. M. (2001a). The behavioral neurology of white matter. New York: Oxford University Press.

    Google Scholar 

  • Filley, C. M. (2001b). Neurobehavioral anatomy (2nd ed.). Boulder: University Press of Colorado.

    Google Scholar 

  • Filley, C. M., & Gross, K. F. (1992). Psychosis with cerebral white matter disease. Neuropsychiatry Neuropsychol Behav Neurol, 5, 119–125.

    Google Scholar 

  • Filley, C. M., & Kleinschmidt-DeMasters, B. K. (1995). Neurobehavioral presentations of brain neoplasms. West J Med, 163, 19–25.

    CAS  PubMed  Google Scholar 

  • Filley, C. M., & Kleinschmidt-DeMasters, B. K. (2001). Toxic leukoencephalopathy. N Engl J Med, 345, 425–432.

    CAS  PubMed  Google Scholar 

  • Filley, C. M., Franklin, G. M., Heaton, R. K., & Rosenberg, N. L. (1988). White matter dementia: clinical disorders and implications. Neuropsychiatry Neuropsychol Behav Neurol, 1, 239–254.

    Google Scholar 

  • Filley, C. M., Heaton, R. K., Nelson, L. M., Burks, J. S., & Franklin, G. M. (1989). A comparison of dementia in Alzheimer’s Disease and multiple sclerosis. Arch Neurol, 46, 157–161.

    CAS  PubMed  Google Scholar 

  • Filley, C. M., Heaton, R. K., & Rosenberg, N. L. (1990). White matter dementia in chronic toluene abuse. Neurology, 40, 532–534.

    CAS  PubMed  Google Scholar 

  • Filley, C. M., Kleinschmidt-DeMasters, B. K., Lillehei, K. O., Damek, D. M., & Harris, J. G. (2003). Gliomatosis cerebri: neurobehavioral and neuropathological observations. Cogn Behav Neurol, 16, 149–159.

    PubMed  Google Scholar 

  • Filley, C. M., Halliday, W., & Kleinschmidt-DeMasters, B. K. (2004). The effects of toluene on the central nervous system. J Neuropathol Exp Neurol, 63, 1–12.

    CAS  PubMed  Google Scholar 

  • Filley, C. M., Kozora, E., Brown, M. S., et al. (2009). White matter microstructure and cognition in non-neuropsychiatric systemic lupus erythematosus. Cogn Behav Neurol, 22, 38–44.

    PubMed  Google Scholar 

  • Franklin, R. J. M., & Ffrench-Constant, C. (2008). Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci, 9, 839–855.

    CAS  PubMed  Google Scholar 

  • Garde, E., Lykke Martensen, E., Rostrup, E., & Paulson, O. B. (2005). Decline in intelligence is associated with progression in white matter hyperintensity volume. J Neurol Neurosurg Psychiatry, 76, 1289–1291.

    CAS  PubMed  Google Scholar 

  • Geer, C. P., & Grossman, S. A. (1997). Interstitial flow along white matter tracts: a potentially important mechanism for the dissemination of primary brain tumors. J Neurooncol, 32, 193–201.

    CAS  PubMed  Google Scholar 

  • Geschwind, N. (1965). Disconnexion syndromes in animals and man. Brain, 88(237–294), 585–644.

    CAS  PubMed  Google Scholar 

  • Giese, A., & Westphal, M. (1996). Glioma invasion in the central nervous system. Neurosurgery, 39, 235–250.

    CAS  PubMed  Google Scholar 

  • Gongvatana, A., Schweinsburg, B. C., Taylor, M. J., et al. (2009). White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals. J Neurovirol, 15, 187–195.

    PubMed  Google Scholar 

  • Graham, D. I., Adams, J. H., Murray, L. S., & Jennett, B. (2005). Neuropathology of the vegetative state after head injury. Neuropsyhol Rehab, 15, 198–213.

    CAS  Google Scholar 

  • Hachinski, V. C. (1991). Binswanger’s disease: neither Binswanger’s nor a disease. J Neurol Sci, 103, 1.

    CAS  PubMed  Google Scholar 

  • Hachinski, V. C., Potter, P., & Merskey, H. (1987). Leuko-araiosis. Arch Neurol, 44, 21–23.

    CAS  PubMed  Google Scholar 

  • Hardy, J. (2009). The amyloid hypothesis for Alzheimer’s Disease: a critical reappraisal. J Neurochem, 110, 1129–1134.

    CAS  PubMed  Google Scholar 

  • Harris, J. G., & Filley, C. M. (2001). CADASIL: Neuropsychological findings in three generations of an affected family. J Int Neuropsychol Soc, 7, 768–774.

    CAS  PubMed  Google Scholar 

  • Hinchey, J., Chaves, C., Appignani, B., et al. (1996). A reversible posterior leukoencephalopathy syndrome. N Engl J Med, 334, 494–500.

    CAS  PubMed  Google Scholar 

  • Hormes, J. T., Filley, C. M., & Rosenberg, N. L. (1986). Neurologic sequelae of chronic solvent vapor abuse. Neurology, 36, 698–702.

    CAS  PubMed  Google Scholar 

  • Hyde, T. M., Ziegler, J. C., & Weinberger, D. R. (1992). Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis. Arch Neurol, 49, 401–406.

    CAS  PubMed  Google Scholar 

  • Jones, H. R., Ho, D. D., Forgacs, P., et al. (1988). Acute fulminating fatal leukoencephalopathy as the only mainfestation of human immunodeficiency virus infection. Ann Neurol, 23, 519–522.

    PubMed  Google Scholar 

  • Kirk, A., Kertesz, A., & Polk, M. J. (1991). Dementia with leukoencephalopathy in systemic lupus erythematosus. Can J Neurol Sci, 18, 344–348.

    CAS  PubMed  Google Scholar 

  • Kochunov, P., Coyle, T., Lancaster, J., et al. (2010). Processing speed is correlated with cerebral health markers in the frontal lobes quantified by neuroimaging. Neuroimage, 49, 1190–1199.

    CAS  PubMed  Google Scholar 

  • Kozora, E., Thompson, L. L., West, S. G., & Kotzin, B. L. (1996). Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease. Arthritis Rheum, 39, 2035–2045.

    CAS  PubMed  Google Scholar 

  • Kraus, M., Susmaras, T., Caughlin, B. P., et al. (2007). White matter injury and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain, 130, 2508–2519.

    PubMed  Google Scholar 

  • Kurtzke, J. F. (1970). Neurologic impairment in multiple sclerosis and the disability status scale. Acta Neurol Scand, 46, 493–512.

    CAS  PubMed  Google Scholar 

  • Lafosse, J. M., Corboy, J. R., Leehey, M. A., Seeberger, L. C., & Filley, C. M. (2007). MS vs. HD: Can white matter and subcortical gray matter pathology be distinguished neuropsychologically? J Clin Exp Neuropsychol, 29, 142–54.

    PubMed  Google Scholar 

  • Langlois, J., Rutland-Brown, W., & Thomas, K. (2004). Traumatic brain injury in the United States: Emergency department visits, hospitalizations and deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention.

    Google Scholar 

  • Laule, C., Koslowski, P., Leung, E., et al. (2008). Myelin water imaging of multiple sclerosis at 7 T: correlations with histopathology. Neuroimage, 40, 1575–1580.

    PubMed  Google Scholar 

  • Luria, A. R. (1966). Higher cortical functions in man. New York: Consultants Bureau.

    Google Scholar 

  • Madden, D. J., Bennett, I. J., & Song, A. W. (2009). Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging. Neuropsychol Rev, 19, 415–35.

    PubMed  Google Scholar 

  • Markham, J. A., & Greenough, W. T. (2004). Experience-driven brain plasticity: beyond the synapse. Neuron Glia Biol, 1, 351–363.

    PubMed  Google Scholar 

  • Martí-Fàbregas, J., Romaguera-Ros, M., Gómez-Pinedo, U., et al. (2010). Proliferation in the human ipsilateral subventricular zone after ischemic stroke. Neurology, 74, 357–365.

    PubMed  Google Scholar 

  • Medana, I. M., & Esiri, M. M. (2003). Axonal damage: a key predictor of outcome in human CNS diseases. Brain, 126, 515–530.

    CAS  PubMed  Google Scholar 

  • Mesulam, M.-M. (1990). Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann Neurol, 28, 597–613.

    CAS  PubMed  Google Scholar 

  • Mesulam, M.-M. (2000). Behavioral neuroanatomy. Large-scale neural networks, association cortex, frontal systems, the limbic system, and hemispheric specializations. In M.-M. Mesulam (Ed.), Principles of behavioral and cognitive neurology (2nd ed., pp. 1–120). New York: Oxford University Press.

    Google Scholar 

  • Miller, E. M. (1994). Intelligence and brain myelination: a hypothesis. Person Individ Diff, 17, 803–832.

    Google Scholar 

  • Miller, A., Korem, M., Almog, R., & Galboiz, Y. (2005). Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci, 233, 93–97.

    CAS  PubMed  Google Scholar 

  • Mori, S., Oiski, K., & Faria, A. V. (2009). White matter atlases based on diffusion tensor imaging. Curr opin neurol, 22, 362–369.

    PubMed  Google Scholar 

  • Navia, B. A., Jordan, B. D., & Price, R. W. (1986a). The AIDS dementia complex: I. Clinical features. Ann Neurol, 19, 517–524.

    CAS  Google Scholar 

  • Navia, B. A., Cho, E.-S., Petito, C. K., & Price, R. W. (1986b). The AIDS dementia complex: II. Neuropathology. Ann Neurol, 19, 525–535.

    CAS  Google Scholar 

  • Nolte, J. (2002). The human brain (5th ed.). St. Louis: Mosby.

    Google Scholar 

  • Owen, A. M., Coleman, M. R., Boly, M., et al. (2005). Detecting awareness in the vegetative state. Science, 313, 1402.

    Google Scholar 

  • Pantoni, L., & Garcia, J. H. (1997). Pathogenesis of leukoaroisis. A review. Stroke, 28, 652–659.

    CAS  PubMed  Google Scholar 

  • Penny, S., Khaleeli, Z., Cipolotti, L., Thompson, A., & Ron, M. (2010). Early imaging predicts later cognitive impairment in primary progressive multiple sclerosis. Neurology, 74, 545–552.

    CAS  PubMed  Google Scholar 

  • Pennypacker, L. C., Allen, R. H., Kelly, J. P., et al. (1992). High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc, 40, 1197–1204.

    CAS  PubMed  Google Scholar 

  • Petersen, R. C., Smith, G. E., Waring, S. C., et al. (1999). Mild cognitive impairment: clinical characterization and outcome. Arch Neurol, 56, 303–308.

    CAS  PubMed  Google Scholar 

  • Pfefferbaum, A., Rosenbloom, M. J., Rohlfing, T., et al. (2009). Frontostriatal fiber bundle compromise in HIV infection without dementia. AIDS, 23, 1977–1985.

    PubMed  Google Scholar 

  • Rabbitt, P., Scott, M., Lunn, M., Thacker, N., Lowe, C., Pendleton, N., et al. (2007). White matter lesions account for all age-related declines in speed but not in intelligence. Neuropsychology, 21, 363–370.

    PubMed  Google Scholar 

  • Rao, S. M., Leo, G. J., Bernardin, L., & Unverzagt, F. (1991). Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology, 41, 685–691.

    CAS  PubMed  Google Scholar 

  • Rollins, K. E., Kleinschmidt-DeMasters, B. K., Corboy, J. R., Damek, D. M., & Filley, C. M. (2005). Lymphomatosis cerebri as a cause of white matter dementia. Hum Pathol, 36, 282–290.

    PubMed  Google Scholar 

  • Román, G. C. (1996). From UBOs to Binswanger’s disease. Impact of magnetic resonance imaging on vascular dementia research. Stroke, 27, 1269–1273.

    PubMed  Google Scholar 

  • Román, G. C., Tatemichi, T. K., Erkinjuntti, T., et al. (1993). Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology, 43, 250–60.

    PubMed  Google Scholar 

  • Rosenberg, N. L., Spitz, M. C., Filley, C. M., et al. (1988a). Central nervous system effects of chronic toluene abuse—clinical, brainstem evoked response and magnetic resonance imaging studies. Neurotoxicol Teratol, 10, 489–495.

    CAS  Google Scholar 

  • Rosenberg, N. K., Kleinschmidt-DeMasters, B. K., Davis, K. A., et al. (1988b). Toluene abuse causes diffuse central nervous system white matter changes. Ann Neurol, 23, 611–614.

    CAS  Google Scholar 

  • Saver, J. L. (2006). Time is brain—quantified. Stroke, 37, 263–266.

    PubMed  Google Scholar 

  • Schiff, N. D., Rodriguez-Moreno, D., Kamal, A., et al. (2005). fMRI reveals large-scale network activation in minimally conscious patients. Neurology, 64, 514–523.

    CAS  PubMed  Google Scholar 

  • Schmahmann, J. D., & Pandya, D. N. (2006). Fiber pathways of the brain. New York: Oxford University Press.

    Google Scholar 

  • Schmahmann, J. D., & Pandya, D. N. (2008). Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems. Cortex, 44, 1037–1066.

    PubMed  Google Scholar 

  • Schmahmann, J. D., Smith, E. D., Eichler, F. S., & Filley, C. M. (2008). Cerebral white matter. Neuroanatomy, clinical neurology, and neurobehavioral correlates. Ann NY Acad Sci, 1142, 266–309.

    CAS  PubMed  Google Scholar 

  • Schoenemann, P. T., Sheehan, M. J., & Glotzer, L. D. (2005). Prefrontal white matter is disproportionately larger in humans than in other primates. Nat Neurosci, 8, 242–252.

    CAS  PubMed  Google Scholar 

  • Selnes, O. A., & Vinters, H. V. (2006). Vascular cognitive impairment. Nat Clin Prac Neurol, 2, 538–547.

    Google Scholar 

  • Smith, D. H., Meaney, D. F., & Shull, W. H. (2003). Diffuse axonal injury in head trauma. J Head Trauma Rehabil, 18, 307–316.

    PubMed  Google Scholar 

  • Stadelmann, C., Albert, M., Wegner, C., & Brück, W. (2008). Cortical pathology in multiple sclerosis. Curr Opin Neurol, 21, 239–234.

    Google Scholar 

  • Stojsavljević, N., Lević, Z., Drulović, J., & Dragutinović, G. (1997). A 44-month clinical-brain MRI follow-up in a patient with B12 deficiency. Neurology, 49, 878–881.

    PubMed  Google Scholar 

  • Sullivan, E. V., & Pfefferbaum, A. (2003). Diffusion tensor imaging in normal aging and neurpsychiatric disorders. Eur J Radiol, 45, 24–255.

    Google Scholar 

  • Sullivan, E. V., & Pfefferbaum, A. (2010). Diffusion in ageing and age-related neurodegenerative disorders. In D. K. Jones (Ed.), Diffusion MRI: Theory, methods and applications. New York: Oxford University Press.

    Google Scholar 

  • Thurnher, M. M., Schindler, E. G., Thurnher, S. A., et al. (2000). Highly active antiretroviral therapy for patients with AIDS dementia complex: effect on MR imaging findings and clinical course. AJNR, 21, 670–678.

    CAS  PubMed  Google Scholar 

  • Turken, A. U., Whitfield-Gabrieli, S., Bammer, R., et al. (2008). Cognitive speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies. Neuroimage, 42, 1032–1044.

    PubMed  Google Scholar 

  • van der Knaap, M., Prank, J. C., & Scheper, G. C. (2006). Vanishing white matter disease. Lancet Neurol, 5, 413–423.

    PubMed  Google Scholar 

  • van Gijn, J. (1998). Leukaraiosis and vascular dementia. Neurology, 51(Suppl 3), S3–S8.

    PubMed  Google Scholar 

  • West, S. G. (1994). Neuropsychiatric lupus. Rheum Dis Clin N Am, 20, 129–158.

    CAS  Google Scholar 

  • Yücel, M., Takagi, M., Walterfang, M., & Lubman, D. I. (2008). Toluene misuse and long-term harms: a systematic review of the neuropsychological and neuroimaging literature. Neurosci Biobehav Rev, 32, 910–926.

    PubMed  Google Scholar 

  • Zahr, N. M., Rohlfing, T., Pfefferbaum, A., & Sullivan, E. V. (2009). Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: a quantitative fiber tracking study. Neuroimage, 44, 1050–62.

    PubMed  Google Scholar 

  • Zhao, C., Deng, W., & Gage, F. H. (2008). Mechanisms and functional implications of adult neurogenesis. Cell, 132, 645–660.

    CAS  PubMed  Google Scholar 

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Acknowledgements

Preparation of this article was supported by National Institutes of Health research grants R01 AR049152-02S1 and R01 AR049152-01A2.

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The author declares that no conflicts of interest are associated with the preparation of this article.

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  1. Behavioral Neurology Section, University of Colorado Denver School of Medicine, Denver, CO, USA

    Christopher M. Filley

  2. Denver Veterans Affairs Medical Center, Denver, CO, USA

    Christopher M. Filley

  3. Behavioral Neurology Section, 12631 East 17th Avenue, MS B185, P.O. Box 6511, Aurora, CO, 80045, USA

    Christopher M. Filley

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Filley, C.M. White Matter: Organization and Functional Relevance. Neuropsychol Rev 20, 158–173 (2010). https://doi.org/10.1007/s11065-010-9127-9

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Keywords

  • White matter
  • Geschwind
  • Disconnection
  • Distributed neural networks
  • White matter dementia