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A Comprehensive Review of Essential Oils and Their Pharmacological Activities in Neurological Disorders: Exploring Neuroprotective Potential

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Abstract

Numerous studies have demonstrated essential oils’ diverse chemical compositions and pharmacological properties encompassing antinociceptive, anxiolytic-like, and anticonvulsant activities, among other notable effects. The utilization of essential oils, whether inhaled, orally ingested, or applied topically, has commonly been employed as adjunctive therapy for individuals experiencing anxiety, insomnia, convulsions, pain, and cognitive impairment. The utilization of synthetic medications in the treatment of various disorders and symptoms is associated with a wide array of negative consequences. Consequently, numerous research groups across the globe have been prompted to explore the efficacy of natural alternatives such as essential oils. This review provides a comprehensive overview of the existing literature on the pharmacological properties of essential oils and their derived compounds and the underlying mechanisms responsible for these observed effects. The primary emphasis is on essential oils and their constituents, specifically targeting the nervous system and exhibiting significant potential in treating neurodegenerative disorders. The current state of research in this field is characterized by its preliminary nature, highlighting the necessity for a more comprehensive overlook of the therapeutic advantages of essential oils and their components. Integrating essential oils into conventional therapies can enhance the effectiveness of comprehensive treatment regimens for neurodegenerative diseases, offering a more holistic approach to addressing the multifaceted nature of these conditions.

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Acknowledgements

The authors would like to thank An-Najah National University.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

    Mohammad Qneibi, Sosana Bdir, Mohammad Bdair, Dana Sandouka, Diana Basit & Mira Hallak

  2. Neuro-Pal Center, Birzeit, Palestine

    Celine Maayeh

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  1. Mohammad Qneibi
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  2. Sosana Bdir
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  3. Celine Maayeh
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Contributions

M. Q.: Conceptualization, Validation, Investigation, Resources, Data curation, Writing – original draft, Writing - review & editing, Visualization, Supervision, Project administration. S. B.: Writing - review & editing, Data curation, Validation. C. M.: Writing - review & editing, Data curation,Validation. M. B.: Writing - review & editing. D. S.: Writing - review & editing. D. B.: Writing - review & editing. M. H.: Writing - review & editing.

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Qneibi, M., Bdir, S., Maayeh, C. et al. A Comprehensive Review of Essential Oils and Their Pharmacological Activities in Neurological Disorders: Exploring Neuroprotective Potential. Neurochem Res 49, 258–289 (2024). https://doi.org/10.1007/s11064-023-04032-5

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