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Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases

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Abstract

The medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD). Apart from PD, Mucuna pruriens is now being studied in models of other nervous systems disorders such as Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS) and stroke because of its neuroprotective importance. This review briefly discusses the pathogenesis of PD, AD, ALS and stroke. It aims to summarize the medicinal importance of Mucuna pruriens in treatment of these diseases, and put forward the potential targets where Mucuna pruriens can act for therapeutic interventions. In this review, the effect of Mucuna pruriens on ameliorating the neurodegeneration evident in PD, AD, ALS and stroke is briefly discussed. The potential targets for neuroprotection by the plant are delineated, which can be studied further to validate the hypothesis regarding the use of Mucuna pruriens for the treatment of these diseases.

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Acknowledgements

WZ, HB, SSS, ASR, HD, RS, and PK are sincerely thankful to BHU, DBT, ICMR, CSIR India, for their respective fellowship. The authors would also like to thanks and acknowledge Ms. Jenan Husain, Graduate student, Neuroscience graduate program, University of Vermont, USA for assistance in English language correction.

Funding

The present study was not supported by any funding agencies.

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

    Walia Zahra, Hareram Birla, Saumitra Sen Singh, Aaina Singh Rathore, Hagera Dilnashin, Richa Singh, Priyanka Kumari Keshri & Surya Pratap Singh

  2. Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Priyanka Gautam

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  1. Walia Zahra
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  2. Hareram Birla
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Contributions

WZ planned the review and drafted the manuscript; HB, SSS, ASR, HD, RS & PKK helped in the manuscript preparation, designed and drawn the figures; and SPS guided throughout the manuscript.

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Correspondence to Surya Pratap Singh.

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Zahra, W., Birla, H., Singh, S.S. et al. Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases. Neurochem Res 47, 1816–1829 (2022). https://doi.org/10.1007/s11064-022-03591-3

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