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The Effects of the Olig Family on the Regulation of Spinal Cord Development and Regeneration

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Abstract

Neurons and glial cells in the central nervous system (CNS) are generated from neuroepithelial cells in the ventricular zone that surrounds the embryonic neural tube. The proliferation and distinct differentiation of neural precursors occurs at certain stages and are regulated by a series of transcription factors leading to the generation of neuronal and glial cell subtypes. In this manuscript, we review the effects of the Olig family, namely, members Olig1, Olig2 and Olig3, on the distinct differentiation of glial and neuronal cells in the developing spinal cord and injured neural tissue.

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Acknowledgements

This work was supported by grants from national natural fund of China (NSFC: grant number: 81772066). There is no conflict of interest.

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Authors and Affiliations

  1. Research Institute of Surgery, Daping Hospital, the Army Military Medical University, Chongqing City, China

    Yuan Liu, Zai-yun Long & Ce Yang

  2. State Key Laboratory of Trauma, Burns and Combined Injury, No. 10 Changjiang Road, Chongqing, 400042, China

    Yuan Liu & Ce Yang

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  1. Yuan Liu
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  2. Zai-yun Long
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Correspondence to Yuan Liu or Ce Yang.

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Liu, Y., Long, Zy. & Yang, C. The Effects of the Olig Family on the Regulation of Spinal Cord Development and Regeneration. Neurochem Res 46, 2776–2782 (2021). https://doi.org/10.1007/s11064-021-03383-1

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