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Neurochemical Research

, Volume 44, Issue 8, pp 1869–1877 | Cite as

Food Selection of Cafeteria Diet Affects Memory Dysfunction Related to Obesity

  • Grace dos Santos Feijó
  • Simone de Oliveira
  • Rutiane Thoen
  • Ester Elena Schaab
  • Ana Carolina de Moura
  • Felipe Franco
  • Márcia Giovenardi
  • Marilene Porawski
  • Renata Padilha GuedesEmail author
Original Paper

Abstract

Cafeteria diet (CAF) mimics human Western diet and has been used in animal models to study obesity. The purpose of this study is to demonstrate that our CAF model induces metabolic disorder related to obesity and affects recognition memory in Wistar rats. We also compared the intake of two different soft drinks, as part of the CAF, on recognition memory. Our results demonstrate that CAF-fed rats increased weight gain and visceral adiposity, and exhibited hyperglycemia, hypertriglyceridemia, high leptin and low insulin plasma levels. Moreover, CAF animals showed higher lipid peroxidation in the liver and developed non-alcoholic fatty liver disease. Surprisingly, the group fed with cola-based soft drinks presented an improvement in recognition memory, whereas animals fed with orange-based soft drinks showed worse performance in this task. Our data indicates that CAF induces obesity and affects recognition memory, but the composition of the diet interfere when the neurological function is evaluated.

Keywords

Diet-induced obesity Object recognition test Cola-based soft drink Metabolic dysfunction Oxidative stress Non-alcoholic fatty liver disease 

Notes

Acknowledgments

This study was supported by the Brazilian National Council for Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Foundation for Research Support of the State of Rio Grande do Sul (FAPERGS).

Author Contributions

GSF, ACM performed experiments, analyzed data, and wrote the manuscript. SO, RT, EES and FF performed experiments. MG and MP contributed to data analysis and editing of the manuscript. RPG designed the study, interpreted the results and wrote the manuscript. All authors read and approved the final manuscript.

Funding

This study was supported by the Brazilian National Council for Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Foundation for Research Support of the State of Rio Grande do Sul (FAPERGS).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest regarding this study.

Ethical Approval

All efforts were made to minimize animal suffering and to reduce the number of animals used in the experiments, which were performed in accordance with the international laws for the care of laboratory animals, following the 3Rs guidelines. All procedures were approved by the Institutional Animal Care and Use Committee (UFCSPA, Brazil, protocol No.536/17). This article does not contain any studies with human participants performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Grace dos Santos Feijó
    • 1
  • Simone de Oliveira
    • 2
  • Rutiane Thoen
    • 3
  • Ester Elena Schaab
    • 4
  • Ana Carolina de Moura
    • 1
  • Felipe Franco
    • 4
  • Márcia Giovenardi
    • 1
    • 2
  • Marilene Porawski
    • 1
    • 2
    • 3
  • Renata Padilha Guedes
    • 1
    • 2
    Email author
  1. 1.Programa de Pós-Graduação Em BiociênciasUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)Porto AlegreBrazil
  2. 2.Programa de Pós-Graduação Em Ciências da SaúdeUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)Porto AlegreBrazil
  3. 3.Programa de Pós-Graduação Em Medicina: HepatologiaUniversidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)Porto AlegreBrazil
  4. 4.Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)Porto AlegreBrazil

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