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Neurochemical Research

, Volume 43, Issue 1, pp 3–11 | Cite as

Origin of Oligodendrocytes in the Vertebrate Optic Nerve: A Review

  • Katsuhiko OnoEmail author
  • Yukie Hirahara
  • Hitoshi Gotoh
  • Tadashi Nomura
  • Hirohide Takebayashi
  • Hisao Yamada
  • Kazuhiro Ikenaka
Review Paper
  • 471 Downloads

Abstract

One of the unsolved problems in the research field of oligodendrocyte (OL) development has been the site(s) of origin of optic nerve OLs and its precursor cells (OPCs). It is generally accepted that OLs in the optic nerve are derived from the brain, and thus optic nerve OLs are immigrant cells. We previously demonstrated the brain origin of optic nerve OPCs in chick embryos. However, the site of optic nerve OPC origin has not been examined experimentally in developing rodents for the past two decades. We have recently reported that optic nerve OPCs in mice arise in the preoptic area by E12.5 and gradually migrate caudally and enter the optic nerve. These OPCs give rise to myelinating OLs in the optic nerve in the postnatal or adult stages. Surprisingly, there are species differences with respect to the origin of optic nerve OPCs between chicks and mice. Here, we summarize the site of OPC origin in the optic nerve based on our own previous and recent results, and discuss possible mechanisms underlying these species differences.

Keywords

Preoptic area Olig2 PDGFRα Oligodendrocyte precursor cell Chick embryo Mouse fetus 

Abbreviations

AEP

Anterior entopeduncular area

CNS

Central nervous system

CreER

Cre recombinase-estrogen receptor fusion protein (gene)

DiI

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (fluorescent dye)

EGFP

Enhanced green fluorescent protein

GalC

Galactocerebroside

MGE

Medial ganglionic eminence

O-2A cell

Oligodendrocyte-type2 astrocyte cell

OL

Oligodendrocyte

OPC

Oligodendrocyte precursor cell

PDGF

Platelete-derived growth factor

PDGFRα

Platelete-derived growth factor receptor alpha subunit

POA

Preoptic area

Shh

Sonic hedgehog

Notes

Acknowledgements

We would like to express our sincere appreciation to Ms. Masako Kawano for technical help, and to Dr. Martyn Goulding for providing reporter mice. This work was supported by a Grant-in-Aid for Scientific research provided by JSPS to KO (JP17K07079) to YH (JP26430077), Grant-in-Aid for Scientific Research on Innovative Areas “Glia assembly” by MEXT (JP25117005, JP25117007) to KI and HT, and also by a collaboration Grant provided by NIPS.

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflicts of interest.

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© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Developmental NeurobiologyKyoto Prefectural University of MedicineKyotoJapan
  2. 2.Department of Anatomy and Cell ScienceKansai Medical UniversityOsakaJapan
  3. 3.Division of Neurobiology and AnatomyNiigata UniversityNiigataJapan
  4. 4.Division of Neurobiology and BioinformaticsNational Institute for Physiological Sciences (NIPS)OkazakiJapan
  5. 5.Department of Physiological Sciences, School of Life ScienceThe Graduate University of Advanced Studies (Sokendai)Miki-choJapan

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