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Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus

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Abstract

The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep spindles and augment the firing rate of neurons in ventrolateral preoptic nucleus, but the underlining mechanism is yet to be known. By using patch clamp recording on neuron in acute brain slice, present study tested if histaminergic H1 and H2 receptors play a role in the effect of propofol on the noradrenalin-inhibited neurons in ventrolateral preoptic nucleus. We found that the firing rate of noradrenalin-inhibited neurons were significantly augmented by propofol; the frequency of inhibitory postsynaptic currents of noradrenalin-inhibited neuron were evidently attenuated by propofol; such inhibition effect was suppressed by histamine; and both triprolidine (antagonist for H1 histamine receptor) and ranitidine (antagonist for H2 histamine receptor) were able to increase the inhibition rate of propofol in presence of histamine. Present study demonstrated that propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibited neurons were mediated by histaminergic H1 and H2 receptors.

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Acknowledgements

This work was supported by a Grant from National Natural Science Foundation of China (81460219 and 81571026).

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    Authors and Affiliations

    1. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, Zunyi, 563000, China

      Yang Liu & Kun Qian

    2. Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, 563000, China

      Yu Zhang, Lin Zhang & Tian Yu

    3. Zunyi Medical College, Dalian road 149, Zunyi, 563000, Guizhou, China

      Tian Yu

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    1. Yang Liu
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    2. Yu Zhang
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    3. Kun Qian
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    4. Lin Zhang
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    Correspondence to Tian Yu.

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    The authors declare that there is no conflict of interests regarding the publication of this paper.

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    Yang Liu and Yu Zhang have equally contributed on this work.

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    Liu, Y., Zhang, Y., Qian, K. et al. Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus. Neurochem Res 42, 1387–1393 (2017). https://doi.org/10.1007/s11064-017-2187-y

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