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Neural Signaling Metabolites May Modulate Energy Use in Hibernation

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Abstract

Despite an epidemic in obesity and metabolic syndrome limited means exist to effect adiposity or metabolic rate other than life style changes. Here we review evidence that neural signaling metabolites may modulate thermoregulatory pathways and offer novel means to fine tune energy use. We extend prior reviews on mechanisms that regulate thermogenesis and energy use in hibernation by focusing primarily on the neural signaling metabolites adenosine, AMP and glutamate.

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Acknowledgements

This material is based upon work supported by the National Science Foundation under Grant Number (NSF IOS-1258179) and by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R03NS081637. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Department of Chemistry and Biochemistry, Institute of Arctic Biology, University of Alaska Fairbanks, 902 N. Koyukuk Drive, Fairbanks, AK, 99775, USA

    Kelly L. Drew, Carla Frare & Sarah A. Rice

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  1. Kelly L. Drew
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Correspondence to Kelly L. Drew.

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Drew, K.L., Frare, C. & Rice, S.A. Neural Signaling Metabolites May Modulate Energy Use in Hibernation. Neurochem Res 42, 141–150 (2017). https://doi.org/10.1007/s11064-016-2109-4

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