Neurochemical Research

, Volume 41, Issue 1–2, pp 222–230 | Cite as

Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular–Subventricular Zone

  • Yuki Hirota
  • Masato Sawada
  • Shih-hui Huang
  • Takashi Ogino
  • Shinya Ohata
  • Akiharu Kubo
  • Kazunobu Sawamoto
Original Paper

Abstract

In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular–subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions.

Keywords

Adult neurogenesis Ventricular–subventricular zone Neural stem cells Wnt signaling β-Catenin Planar cell polarity Regeneration 

Abbreviations

APC

Adenomatous polyposis coli

Celsr

Cadherin EGF LAG seven-pass G-type receptor

CNS

Central nervous system

CSF

Cerebrospinal fluid

DAPI

4′,6-Diamidino-2-phenylindole

DKK

Dickkopf

Dvl

Dishevelled

Fzd

Frizzled

GSK3β

Glycogen synthase kinase 3β

Hipk1

Homeodomain-interacting protein kinase-1

JNK

c-Jun N-terminal kinase

LEF

Lymphoid enhancer binding factor

NPC

Neural progenitor cell

NSC

Neural stem cell

OB

Olfactory bulb

OPC

Oligodendrocyte progenitor cell

PCP

Planar cell polarity

RMS

Rostral migratory stream

SGZ

Subgranular zone

TCF

T cell transcription factor

TLX

Tailless

Vangl2

Van Gogh like-2

V-SVZ

Ventricular–subventricular zone

WIP1

Wild-type p53-induced phosphatase 1

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yuki Hirota
    • 1
  • Masato Sawada
    • 1
  • Shih-hui Huang
    • 1
  • Takashi Ogino
    • 1
  • Shinya Ohata
    • 2
  • Akiharu Kubo
    • 3
  • Kazunobu Sawamoto
    • 1
  1. 1.Department of Developmental and Regenerative BiologyNagoya City University Graduate School of Medical SciencesNagoyaJapan
  2. 2.Laboratory of Physiological Chemistry, Graduate School of Pharmaceutical SciencesUniversity of TokyoTokyoJapan
  3. 3.Department of DermatologyKeio University School of MedicineTokyoJapan

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