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Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats

A Correction to this article was published on 04 May 2022

An Erratum to this article was published on 26 August 2015

This article has been updated

Abstract

The present study was aimed to evaluate the protective effect of hesperidin (Hes) on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats. Intraperitonial injection of AlCl3 (100 mg/kg body weight) for 60 days significantly elevated the levels of aluminium (Al), activity of acetylcholinesterase (AChE) and protein expressions of amyloid precursor protein (APP), β amyloid (Aβ1–42), β and γ secretases as compared to control group in hippocampus and cortex of rat brain. Hes administration orally along with AlCl3 injection for 60 days, significantly revert the Al concentration, AChE activity and Aβ synthesis-related molecules in the studied brain regions. Our results showed that aluminum exposure was significantly reduced the spontaneous locomotor and exploratory activities in open field test and enhanced the learning and memory impairments in morris water maze test. The behavioral impairments caused by aluminum were significantly attenuated by Hes. The histopathological studies in the hippocampus and cortex of rat brain also supported that Hes (100 mg/kg) markedly reduced the toxicity of AlCl3 and preserved the normal histoarchitecture pattern of the hippocampus and cortex. From these results, it is concluded that hesperidin can reverse memory loss caused by aluminum intoxication through attenuating AChE activity and amyloidogenic pathway.

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Acknowledgments

Financial assistance in the form of a major research project from the Department of Science and Technology, New Delhi, is gratefully acknowledged.

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Hereby, the authors declare that they have no conflict of interest that might have influenced the views expressed in this manuscript.

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Correspondence to Arokiasamy Justin Thenmozhi.

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Thenmozhi, A.J., Raja, T.R.W., Janakiraman, U. et al. Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats. Neurochem Res 40, 767–776 (2015). https://doi.org/10.1007/s11064-015-1525-1

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  • DOI: https://doi.org/10.1007/s11064-015-1525-1

Keywords

  • Alzheimer’s disease
  • AlCl3
  • Hesperidin
  • Memory loss
  • Aβ synthesis