Neurochemical Research

, Volume 40, Issue 1, pp 118–123 | Cite as

Neuroprotective Effects of Trans-Caryophyllene Against Kainic Acid Induced Seizure Activity and Oxidative Stress in Mice

  • Hao Liu
  • Zhi Song
  • Daguang Liao
  • Tianyi Zhang
  • Feng Liu
  • Kai Zhuang
  • Kui Luo
  • Liang Yang
Original Paper


Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven’t been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation. We found that TC pretreatment significantly decreased seizure activity score compared to kainic acid treated group. Importantly, TC pretreatment leads to lowering the mortality in kainic acid treated mice. In addition, TC was found to significantly inhibit KA-induced generation of malondialdehyde. TC pretreatment also preserved the activity of GPx, SOD, and CAT. Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β. These data suggest that TC has a potential protective effect on chemical induced seizure and brain damage.


Epilepsy Kainic acid Trans-caryophyllene Oxidative stress Inflammation 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Hao Liu
    • 1
  • Zhi Song
    • 2
  • Daguang Liao
    • 1
  • Tianyi Zhang
    • 1
  • Feng Liu
    • 1
  • Kai Zhuang
    • 1
  • Kui Luo
    • 1
  • Liang Yang
    • 1
  1. 1.Department of NeurosurgeryThe Third Xiangya Hospital of Central South UniversityChangshaPeople’s Republic of China
  2. 2.Department of NeurologyThe Third Xiangya Hospital of Central South UniversityChangshaPeople’s Republic of China

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