Neuroprotective Effects of Trans-Caryophyllene Against Kainic Acid Induced Seizure Activity and Oxidative Stress in Mice
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Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven’t been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation. We found that TC pretreatment significantly decreased seizure activity score compared to kainic acid treated group. Importantly, TC pretreatment leads to lowering the mortality in kainic acid treated mice. In addition, TC was found to significantly inhibit KA-induced generation of malondialdehyde. TC pretreatment also preserved the activity of GPx, SOD, and CAT. Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β. These data suggest that TC has a potential protective effect on chemical induced seizure and brain damage.
KeywordsEpilepsy Kainic acid Trans-caryophyllene Oxidative stress Inflammation
- 1.Simon RP, Greenberg DA, Aminof MJ (2009) Clinical neurology, 7th edn. McGraw-Hill, New YorkGoogle Scholar
- 7.Guo K, Mou X, Huang J, Xiong N, Li H (2014) Trans-caryophyllene suppresses hypoxia-induced neuroinflammatory responses by inhibiting NF-κB activation in microglia. J Mol Neurosci [Epub ahead of print]Google Scholar
- 9.Souza MA, Oliveira MS, Furian AF, Rambo LM, Ribeiro LR, Lima FD, Dalla Corte LC, Silva LF, Retamoso LT, Dalla Corte CL, Puntel GO, de Avila DS, Soares FA, Fighera MR, de Mello CF, Royes LF (2009) Swimming training prevents pentylenetetrazol-induced inhibition of Na?, K?-ATPase activity, seizures, and oxidative stress. Epilepsia 50:811–823PubMedCrossRefGoogle Scholar