Neurochemical Research

, Volume 39, Issue 11, pp 2218–2224 | Cite as

Association of Serum 25-Hydroxyvitamin D with Symptoms of Depression After 6 Months in Stroke Patients

  • Wei Yue
  • Lei Xiang
  • Ya-Jing Zhang
  • Yong Ji
  • Xin LiEmail author
Original Paper


Our aim was to determine whether there was a relationship between 25-hydroxyvitamin D (25[OH] D) and post-stroke depression (PSD). Two hundred and forty-four ischemic stroke patients admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum 25[OH] D levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke. At 6-month, 91 patients (37.3 %) showed depression and in 60 patients (24.6 %) this depression was classified as major. There was a significant difference in median serum 25[OH] D levels between PSD patients and no depression cases [8.3 (IQR, 6.8–9.5) vs. 15.6 (IQR, 13.2–20.3) ng/ml, respectively; P < 0.001]. Serum 25[OH] D levels ≤11.2 ng/ml were independently associated with PSD [odds ratio 10.32, 95 % confidence interval 4.97–28.63; P < 0.001], after adjusting for possible confounders. Serum 25[OH] D levels reduced at admission was found to be associated with PSD. Additional research is needed on vitamin D supplementation to improve the outcome of patients with PSD.


25-Hydroxyvitamin D Stroke Depression Chinese 



We would like to thank the staff and patients with stroke for their cooperation during this study. Authors also acknowledge the contribution of the editors and reviewers who have helped us to improve the manuscript.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Wei Yue
    • 1
    • 2
  • Lei Xiang
    • 1
  • Ya-Jing Zhang
    • 1
  • Yong Ji
    • 1
  • Xin Li
    • 2
    Email author
  1. 1.Department of NeurologyTianjin Huanhu HospitalTianjinPeople’s Republic of China
  2. 2.Department of NeurologySecond Hospital of Tianjin Medical UniversityTianjinPeople’s Republic of China

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