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Neurochemical Research

, Volume 38, Issue 10, pp 2105–2113 | Cite as

The Fruits of Maclura pomifera Extracts Inhibits Glioma Stem-Like Cell Growth and Invasion

  • Dan Zhao
  • Chengyun Yao
  • Xiaobing ChenEmail author
  • Hongping XiaEmail author
  • Li Zhang
  • Huixiang Liu
  • Xiaochun Jiang
  • Yi Dai
  • Jun Liu
Original Paper

Abstract

Glioma is the most common primary intracranial tumour. Recently, growing evidence showed that glioma possesses stem-like cells, which are thought to be chemo- and radio-resistant and believed to contribute to the poor clinical outcomes of these tumours. In this study, we found that stem-like glioma cells (CD133+) were significantly increased in neurosphere cells, which are highly invasive and resistant to multiple chemotherapeutic agents. From our natural products library, we screened 48 natural products and found one compound, Pomiferin, which was of particular interest. Our results showed that Pomiferin could inhibit cell viability, CD133+ cell population, sphere formation, and invasion ability of glioma neurosphere cells. We also found that multiple stemness-associated genes (BIM1, Nestin, and Nanog) were down-regulated by Pomiferin treatment of glioma neurosphere cells. Taken together, our results suggest that Pomiferin could kill the cancer stem-like cells in glioma and may serve as a potential therapeutic agent in the future.

Keywords

Glioma Stem cell CD133 Natural product Pomiferin 

Notes

Acknowledgments

This study was supported by Grants from the National Natural Science Foundation of China; Grant Number: 81201994.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Dan Zhao
    • 1
  • Chengyun Yao
    • 2
  • Xiaobing Chen
    • 3
    Email author
  • Hongping Xia
    • 4
    Email author
  • Li Zhang
    • 1
  • Huixiang Liu
    • 1
  • Xiaochun Jiang
    • 4
  • Yi Dai
    • 4
  • Jun Liu
    • 5
  1. 1.Department of Neurosurgery, Zhangjiagang HospitalSuzhou UniversityZhangjiagangChina
  2. 2.Department of RadiationJiangsu Cancer HospitalNanjingChina
  3. 3.Department of OncologyThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina
  4. 4.Department of Surgery, Yijishan HospitalWannan Medical CollegeWuhuChina
  5. 5.Department of Neurosurgery, Ma’an Shan Central HospitalWannan Medical CollegeMa’an ShanChina

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