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Evaluation of the Possible Epileptogenic Activity of Ciprofloxacin: The Role of Nigella sativa on Amino Acids Neurotransmitters

Neurochemical Research volume 38, pages 174–185 (2013)Cite this article

Abstract

The neuroprotective effect of Nigella sativa (NS) on amino acid neurotransmitters alteration in pentylenetetrazole (PTZ) and ciprofloxacin (CFX) treated rats in different brain regions was examined. The oral administration of NS induced an elevation in aspartate and glutamate contents, whereas the levels of GABA and glycine were decreased. Furthermore, the treated groups with PTZ and CFX caused a decrease in aspartate, glutamate and total antioxidant capacity levels, while the concentrations of GABA and glycine were increased after 14 days. Moreover, the pre- and post-treatment with NS in PTZ and CFX treated rats return the levels of these parameters near control values. So, it could be concluded that the treatment with CFX induced imbalance between the excitatory and the inhibitory amino acids which may lead to the initiation of epileptic seizures and the treatment with NS was found to ameliorate these neurological defects which reflect its potent antiepileptic activity.

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Affiliations

  1. Biology Department, Jazan University, Jazan, Saudi Arabia

    Nadia M. S. Arafa

  2. Department of Physiology, National Organization for Drug Control and Research, Giza, Egypt

    Nadia M. S. Arafa

  3. Zoology and Entomology Department, Faculty of Science, Helwan University, Ain Helwan, Cairo, 11795, Egypt

    Mona Abdel-Rahman, Manal F. El-khadragy & Rami B. Kassab

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  1. Nadia M. S. Arafa
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  2. Mona Abdel-Rahman
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  3. Manal F. El-khadragy
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Arafa, N.M.S., Abdel-Rahman, M., El-khadragy, M.F. et al. Evaluation of the Possible Epileptogenic Activity of Ciprofloxacin: The Role of Nigella sativa on Amino Acids Neurotransmitters. Neurochem Res 38, 174–185 (2013). https://doi.org/10.1007/s11064-012-0905-z

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Keywords

  • Epilepsy
  • Nigella sativa
  • Ciprofloxacin
  • PTZ
  • Aspartate
  • Glutamate
  • GABA
  • Glycine