Amelioration of Age Associated Neuroinflammation on Long Term Bacosides Treatment

Neurochemical Research volume 37, pages869–874(2012)Cite this article

Abstract

Bacopa monnieri (L.) is a revered medicinal plant of traditional Indian system of medicine effective against cognitive impairment in ageing and SDAT. In our previous study, long term administration of bacosides was found to exhibit remarkable anti ageing effect, ameliorate age associated neurochemical and neurobehavioral deficits and prevent hippocampal neuronal degeneration in middle aged and aged rat brain cortex. In continuation to the previous study, the present study aims to investigate the neuroprotective effect of bacosides against age related chronic neuroinflammation in Wistar rat brain on 3 months treatment. Recently, neuroinflammation has gained considerable interest in age associated neurodegeneration and pathologies like SDAT due to its slow onset and chronic nature. The results of the present study demonstrated the significant attenuation of age dependant elevation of pro inflammatory cytokines, iNOS protein expression, total nitrite and lipofuscin content in middle aged and aged rat brain cortex on long term oral administration of bacosides. Thus, the present results suggest that bacosides possess immense potential to act as a neuroprotective agent due to its pleiotropic action for the prevention of ageing complications and SDAT progression.

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Acknowledgments

We acknowledge the Vice Chancellor, SASTRA University for granting permission to carry out this work in Centre for Advanced Research in Indian System of Medicine (CARISM).

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Affiliations

  1. Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur, India

    Manisha Rastogi & Rudra P. Ojha

  2. Department of Pharmacy, School of Chemical and Biotechnology, SASTRA University, Thanjavur, India

    B. Parimala Devi

  3. National Institute of Medical Statistics, ICMR, New Delhi, India

    Aabha Aggarwal

  4. Centre for Psychosomatic and Biofeedback Medicine, IMS, Banaras Hindu University, Varanasi, India

    Aruna Agrawal

  5. Emeritus Scientist, CCRAS, Department of AYUSH, Ministry of Health and Family Welfare, New Delhi, India

    G. P. Dubey

Authors
  1. Manisha Rastogi
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  2. Rudra P. Ojha
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  3. B. Parimala Devi
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  4. Aabha Aggarwal
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  5. Aruna Agrawal
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  6. G. P. Dubey
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Correspondence to G. P. Dubey.

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Rastogi, M., Ojha, R.P., Devi, B.P. et al. Amelioration of Age Associated Neuroinflammation on Long Term Bacosides Treatment. Neurochem Res 37, 869–874 (2012). https://doi.org/10.1007/s11064-011-0681-1

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Keywords

  • Ageing
  • SDAT
  • Inflammation
  • Lipofuscin
  • Bacosides