Neurochemical Research

, Volume 33, Issue 8, pp 1568–1573 | Cite as

Sex Steroids Effects on the Content of GAD, TH, GABAA, and Glutamate Receptors in the Olfactory Bulb of the Male Rat

  • Christian Guerra-Araiza
  • Alfredo Miranda-Martinez
  • Teresa Neri-Gómez
  • Ignacio Camacho-Arroyo
Original Paper


Sex steroids exert multiple functions in the central nervous system. They modulate responses to olfactory information in mammals but their participation in the regulation of neurotransmission in the olfactory bulb is unknown. We studied by Western blot the effects of estradiol (E2), progesterone (P4), and allopregnanolone (Allo) on the content of glutamic acid decarboxylase (GAD), γ-aminobutyric acid A receptor α-2 subunit (GABAAR α-2), glutamate receptor 2/3 (GlutR 2/3), and tyrosine hydroxylase (TH) in the olfactory bulb of gonadectomized male rats. GAD content was increased by all steroids administered alone. Interestingly, progestins reduced E2 effects on GAD content. Steroids increased the content of TH and GABAAR α-2. In contrast, GlutR 2/3 content was decreased by E2 and P4, whereas Allo did not modify it. These results suggest that estrogens and progestins regulate olfactory bulb functions in the male rat by modulating the expression of key proteins involved in several neurotransmission systems.


Olfactory bulb Estradiol Progesterone Glutamic acid decarboxylase Tyrosine hydroxylase GABAA receptor Glutamate receptor 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Christian Guerra-Araiza
    • 1
  • Alfredo Miranda-Martinez
    • 1
  • Teresa Neri-Gómez
    • 2
  • Ignacio Camacho-Arroyo
    • 2
  1. 1.Unidad de Investigación Médica en Farmacología, Hospital de Especialidades, Centro Médico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexicoMexico
  2. 2.Facultad de Química, Departamento de BiologíaUniversidad Nacional Autónoma de MéxicoMexicoMexico

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