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Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat Brain

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Abstract

We investigated the effects of lamotrigine, aripiprazole and escitalopram administration and experimental depression on lipid peroxidation (LP) and antioxidant levels in cortex of the brain in rats. Forty male wistar rats were randomly divided into five groups. First group was used as control although second group was depression-induced group. Aripiprazole, lamotrigine and escitalopram per day were orally supplemented to chronic mild stress (CMS) depression-induced rats constituting the third, fourth and fifth groups for 28 days, respectively. Depression resulted in significant decrease in the glutathione peroxidase (GSH-Px) activity, reduced glutathione and vitamin C of cortex of the brain although their levels and beta-carotene concentrations were increased by the three drugs administrations to the animals of CMS induced depression group. The LP levels in the cortex of the brain and plasma of depression group were elevated although their levels were decreased by the administrations. The increases of antioxidant values in lamotrigine group were higher according to aripiprazole and escitalopram supplemented groups. Vitamin A level did not change in the five groups. In conclusion, the experimental depression is associated with elevated oxidative stress although treatment with lamotrigine has most protective effects on the oxidative stress within three medicines.

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Abbreviations

CMS:

Chronic mild stress

GSH-Px:

Glutathione peroxidase

GSH:

Glutathione

LP:

Lipid peroxidation

MAO:

Monoaminooxidase

MDA:

Malondialdehyde

PUFAs:

Polyunsaturated fatty acids

ROS:

Reactive oxygen species

SSRIs:

Selective- serotonin reuptake inhibitors

SOD:

Superoxide dismutase

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Acknowledgement

Authors wish to thank A. Cihangir Uğuz and Ömer Çelik for excellent help on the analysis of antioxidant parameters.

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Authors and Affiliations

  1. Department of Psychiatry, Medical Faculty, Suleyman Demirel University, Isparta, Turkey

    İbrahim Eren & Arif Demirdaş

  2. Department of Biophysics, Medical Faculty, Suleyman Demirel University, Postakutusu 68 Cunur, Isparta, TR, 32260, Turkey

    Mustafa Nazıroğlu

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  1. İbrahim Eren
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  2. Mustafa Nazıroğlu
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  3. Arif Demirdaş
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Correspondence to Mustafa Nazıroğlu.

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Eren, İ., Nazıroğlu, M. & Demirdaş, A. Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat Brain. Neurochem Res 32, 1188–1195 (2007). https://doi.org/10.1007/s11064-007-9289-x

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  • DOI: https://doi.org/10.1007/s11064-007-9289-x

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