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Human Mesenchymal Stem Cells Signals Regulate Neural Stem Cell Fate

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Abstract

Neural stem cells (NSCs) differentiate into neurons, astrocytes and oligodendrocytes depending on their location within the central nervous system (CNS). The cellular and molecular cues mediating end-stage cell fate choices are not completely understood. The retention of multipotent NSCs in the adult CNS raises the possibility that selective recruitment of their progeny to specific lineages may facilitate repair in a spectrum of neuropathological conditions. Previous studies suggest that adult human bone marrow derived mesenchymal stem cells (hMSCs) improve functional outcome after a wide range of CNS insults, probably through their trophic influence. In the context of such trophic activity, here we demonstrate that hMSCs in culture provide humoral signals that selectively promote the genesis of neurons and oligodendrocytes from NSCs. Cell–cell contacts were less effective and the proportion of hMSCs that could be induced to express neural characteristics was very small. We propose that the selective promotion of neuronal and oligodendroglial fates in neural stem cell progeny is responsible for the ability of MSCs to enhance recovery after a wide range of CNS injuries.

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Acknowledgments

The authors thank Dr. Madjid Belkadi and Rae Wang for help with technical aspects of the manuscript and Anne DeChant for her help with graphics and editorial comments. This work was supported by funds from the Center for Stem Cells and Regenerative Medicine and the Myelin Repair Foundation.

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Authors and Affiliations

  1. Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    Lianhua Bai & Robert H. Miller

  2. Skeletal Research Center, Case Western Reserve University, Cleveland, OH, USA

    Arnold Caplan & Donald Lennon

Authors
  1. Lianhua Bai
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  2. Arnold Caplan
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  3. Donald Lennon
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  4. Robert H. Miller
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Correspondence to Robert H. Miller.

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Special issue dedicated to Anthony Campagnoni.

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Bai, L., Caplan, A., Lennon, D. et al. Human Mesenchymal Stem Cells Signals Regulate Neural Stem Cell Fate. Neurochem Res 32, 353–362 (2007). https://doi.org/10.1007/s11064-006-9212-x

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  • DOI: https://doi.org/10.1007/s11064-006-9212-x

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