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Thudichum’s Successors

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Abstract

This paper describes the work of five scientists who, among others, carried on the work of J. L. W. Thudichum, the pre-eminent investigator of brain chemistry in the latter half of the 19th century, after his death in 1901.

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References

  1. Drabkin DL (1958) Thudichum, chemist of the brain. University of Pennsylvania Press, Philadelphia

    Google Scholar 

  2. McIlwain H (1958) Thudichum and the medical chemistry of the 1860s to 1880s. Proc Roy Soc Med 51:127–132

    PubMed  CAS  Google Scholar 

  3. Sourkes TL (2003) The life and work of J. L. W. Thudichum, 1829–1901. Osler Library, McGill University, Montreal

    Google Scholar 

  4. Sourkes TL (2004) Social and medical origins of neurochemistry. Progr. Neuro-Psychopharm. Biol Psychiat 28:885–890

    CAS  Google Scholar 

  5. Thudichum JLW (1884) A treatise on the chemical constitution of the brain. Baillière, Tindall & Cox, London

    Google Scholar 

  6. Thudichum JLW (1901) Die chemische Konstitution des Gehirns des Menschen und Tiere. Pietzcker, Tübingen

    Google Scholar 

  7. Hoppe-Seyler F, Thierfelder H (1893) Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse. 6th ed. A Hirschwald, Berlin

    Google Scholar 

  8. Thierfelder H (1924) Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse. 9th ed J. Springer, Berlin

    Google Scholar 

  9. Thierfelder H (1889) Űber die Identität des Gehirnzuckers mit Galactose. Hoppe-Seylers Ztsch Physiol Chem 14:209–216

    Google Scholar 

  10. Wörner E, Thierfelder H (1900) Untersuchungen über die chemische Zusammensetzung des Gehirns. Hoppe-Seylers Ztschr Physiol Chem 30:542–551

    Google Scholar 

  11. Thierfelder H (1904) Űber das Cerebron. Hoppe-Seylers Ztsch Physiol Chem 43:21–31

    CAS  Google Scholar 

  12. Thierfelder H, Klenk E (1930) Die Chemie der Cerebroside und Phosphatide. Springer, Berlin

    Google Scholar 

  13. Brigl P (1930) Hans Thierfelder Ber. Deutsch Chem Gesellsch 63(part A):176–177

    Google Scholar 

  14. Klenk E (1930) Hans Thierfelder†. Hoppe-Seylers Ztsch Physiol Chem 203:1–9

    Google Scholar 

  15. Lesch JE (1981) Hans Thierfelder. Dict Scientif Biog 18 (Suppl. 2):904–906

    Google Scholar 

  16. Anonymous (1963) Siegfried Josef Thannhauser. New Engl J Med 268:680–681

    Google Scholar 

  17. Heilmeyer L (1955) S. J. Thannhauser zum 70. Geburtstag Münch Med Wschr 97:1183–1184

    CAS  Google Scholar 

  18. Hohmann G (1963) Zum Andenken an Professor Dr. Siegfried Thannhauser. Münch. Med Wschr 105:357–359

    PubMed  CAS  Google Scholar 

  19. Proger S (1963) Siegfried Josef Thannhauser, M.D., 28. Juni 1885 bis 18. Dezember 1962. Gedenkrede Med Welt 9:482–483

    CAS  Google Scholar 

  20. Zöllner N (1963) Siegfried J. Thannhauser, 1885–1962. Deutsch Med Wchschr 88:337–340

    Google Scholar 

  21. Thannhauser SJ, Benotti J (1938) Untersuchungen über Organlipoide. XIII. Eigenschaften und Struktur des Sphingomyelins aus normaler Milz. Ztschr Physiol Chem 253:217–224

    CAS  Google Scholar 

  22. Thannhauser SJ, Boncoddo NF, Schmidt G (1951a) Studies of acetal phospholipides of brain. I. Procedure of isolation of crystallized acetal phospholipide from brain. J Biol Chem 188:417–421

    CAS  Google Scholar 

  23. Thannhauser SJ, Boncoddo NF, Schmidt G (1951b) Studies of acetal phospholipides of brain. II. The α structure of acetal phospholipide of brain J Biol Chem 188:423–426

    CAS  Google Scholar 

  24. Thannhauser SJ (1940) Lipidoses, diseases of the cellular lipid metabolism. Ed. A Christian. London, New York: Oxford University Press

  25. Thannhauser SJ, Schmidt G (1946) Lipins and lipidoses. Physiol Rev 26:275–317

    Google Scholar 

  26. Ottenstein B, Schmidt G, Thannhauser SJ (1948) Studies concerning the pathogenesis of Gaucher’s disease. Blood 3:1250–1258

    CAS  PubMed  Google Scholar 

  27. Schmidt G (1955) Űber Thannhausers wissenschaftliche Arbeit seit 1935. Deutsch Med Wchschr 80:988–989

    Article  CAS  Google Scholar 

  28. Zöllner N (ed.) (1962–1964) Thannhauser’s textbook of metabolism and metabolic disorders. 2nd ed., tr. S. Estren. New York, London, Grune & Stratton

  29. Himwich HE (1951) Brain metabolism and cerebral disorders. Williams & Wilkins, Baltimore

    Google Scholar 

  30. Himwich HE, Nahum LH (1932) The respiratory quotient of the brain. Am J Physiol 101:446–453

    CAS  Google Scholar 

  31. Himwich HE et al. (1945) Cerebral metabolism in patients with depression. Am J Psychiatry 101:453–454

    CAS  Google Scholar 

  32. Himwich WA et al. (1947) Brain metabolism in man: unanesthetized and in pentothal narcosis. Am J Psychiatry 103:689–696

    CAS  Google Scholar 

  33. Himwich HE et al. (1939) The mechanism of the symptoms of insulin hypoglycaemia. Am J Psychiatry 96:371–385

    CAS  Google Scholar 

  34. Aring CD (1975) Harold E Himwich, 1894–1975. Trans Am Neurol Assoc 100:272–273

    PubMed  CAS  Google Scholar 

  35. Costa E (1975) Harold E Himwich. J Neurochem 25:735–736

    Article  CAS  Google Scholar 

  36. Dill DB (1982) Physiologists at Med Labs, 1946–61. Physiologist 25:475

    Google Scholar 

  37. Wortis J. (1975) Harold . E. Himwich. Biol Psychiatry 10:681–683

    PubMed  CAS  Google Scholar 

  38. Klenk E, Sakai R (1939) Inositmonophosphorsäure, ein Spaltprodukt der Sojabohnenphosphatide. Ztschr Physiol Chem 258:33–38

    CAS  Google Scholar 

  39. Klenk E (1970) On the discovery and chemistry of neuraminic acid and gangliosides. Chem Phys Lipids 5:193–197

    Article  PubMed  CAS  Google Scholar 

  40. Yamakawa T (1988) Thus started ganglioside research. TIBS 13:452–454

    PubMed  CAS  Google Scholar 

  41. Yamakawa T (1996) A reflection on the early history of glycosphingolipids. Glycoconj J 13:123–126

    Article  PubMed  CAS  Google Scholar 

  42. Klenk E (1935) Űber die Natur des Phosphatide und anderer Lipoide des Gehirns und der Leber bei der Niemann-Pickschen Krankheit. Ztschr Physiol Chem 235:24–36

    CAS  Google Scholar 

  43. Klenk E, Schumann E (1940–1941) Beitrage zur Chemie der Lipoidosen. Ztschr Physiol Chem 267:128–144

    CAS  Google Scholar 

  44. Klenk E (1941) Neuraminsäure, das Spaltprodukt eines neuen Gehirnlipoids. Ztschr Physiol Chem 268:50–58

    CAS  Google Scholar 

  45. Klenk E, Debuch H (1955) Zur Kenntnis des cholinhaltigen Plasmalogene (Acetalphosphatide) des Rinderherzmuskels. Ztschr Physiol Chem 499:66–73

    Google Scholar 

  46. Debuch H (1966) Ernst Klenk zum 70. Geburtstag Ztschr Physiol Chem 347 (Suppl):1–2

    Google Scholar 

  47. Debuch H (1973) Ernst Klenk, 1896–1971. J Neurochem 21:725–727

    Article  PubMed  CAS  Google Scholar 

  48. Morgan N (1981) Ernst Klenk. Dict Scientif Biog 17 (Suppl. 2):484–485

    Google Scholar 

  49. Folch J, Schneider HA (1941) An amino acid constituent of ox brain cephalin. J Biol Chem 137:51–62

    CAS  Google Scholar 

  50. Folch J (1942) Brain cephalin, a mixture of phosphatides. Separation from it of phosphatidyl serine, phosphatidyl ethanolamine, and a fraction containing an inositol phosphate. J Biol Chem 146:35–44

    CAS  Google Scholar 

  51. Folch J (1948) The chemical structure of phosphatidyl serine. J Biol Chem 174:439–450

    CAS  PubMed  Google Scholar 

  52. Folch J, Woolley DW (1942) Inositol A constituent of a brain phosphatide. J Biol Chem 142:963–964

    CAS  Google Scholar 

  53. Folch J (1949) Brain diphosphoinositide, a new phosphatide having inositol metadiphosphate as a constituent. J Biol Chem 174:505–519

    Google Scholar 

  54. Folch J, Lees M, Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem 226:497–509

    PubMed  CAS  Google Scholar 

  55. Folch J, Lees M (1951) Proteolipids, a new type pf tissue lipoproteins. Their isolation from brain. J Biol Chem 191:807–817

    PubMed  CAS  Google Scholar 

  56. Folch J, Arsove S, Meath JA (1951) Isolation of brain strandin A new type of large molecule tissue component. J Biol Chem 191:819–831

    PubMed  CAS  Google Scholar 

  57. Folch J, Lees M (1959) Studies on the brain ganglioside strandin in normal brain and in Tay-Sachs disease. AMA J Dis Child 97 (part 2):730–738

    Google Scholar 

  58. Pope A, Lees MB, Hauser G (1981) Jordi Folch-Pi. Neurochem Res 6:1039–1041

    PubMed  CAS  Google Scholar 

  59. Lees NB, Pope A (2001) Jordi Folch, 1911–1979. Biog Memoirs, Nat Acad Sci 79:134–157

    Google Scholar 

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Authors and Affiliations

  1. Departments of Psychiatry, Biochemistry, and Pharmacology and Therapeutics, McGill University, 1033 Pine Avenue West, Montreal, QC, Canada, H3A 1A1

    Theodore L. Sourkes

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  1. Theodore L. Sourkes
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Correspondence to Theodore L. Sourkes.

Additional information

This paper is dedicated to my friend Moussa Ben-Hur Youdim, who spent three years (1963–1966) in my laboratory, as a graduate student in the Department of Biochemistry, McGill University. During this time, Moussa purified monoamine oxidase of rat liver, and provided the first evidence of its multiplicity. He also contributed to the recognition of iron and riboflavin as constituents of the enzyme.

Appendix

Appendix

A selection of reviews of chemistry of the nervous system and of lipids published in the first three decades of the 20th century, presented in chronological order.

Halliburton W. D. (1905) Die Biochemie der peripheren Nerven. Ergebn. d. Physiol. 4: 23–83.

Coriat I. H. (1905) A review of some recent literature on the chemistry of the central nervous system. J. Comp. Neurol. Psychol. 15: 148–159.

Fränkel S. (1909) Gehirn-Chemie. Ergebn. d. Physiol. 8: 212–253.

Peritz G. (1909) Biochemie des Zentralnervensystems. In: Handbuch der Biochemie des Menschen und der Tiere. Ed. C. Oppenheimer. 2 (Part 2): 282–299.

Leathes J. B. (1910) The fats. London: Longmans, Green.

Levene P. A. (1921) Structure and significance of the phosphatides. Physiol. Rev. 1: 327– 393.

Fürth O. (1925) Nervensubstanz und Gehirn. Lehrbuch der physiologischen und pathologischen Chemie. 1: 291–307. Leipzig: Vogel.

MacLean H, MacLean I. S. (1927) Lecithin and allied substances: the lipins. London: Longmans, Green. 2nd ed.

Sando C E (1928) Lipides and their estimation in vegetable tissues. Plant Physiol. 3: 155–184.

Winterstein H. (1929) Der Stoffwechsel des Zentralnervensystems. In: Handbuch der normalen und pathologischen Physiologie. Ed. A. Bethe, G. v. Bergmann, G. Embden, A. Ellinger. Berlin: Springer.

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Sourkes, T.L. Thudichum’s Successors. Neurochem Res 32, 1808–1812 (2007). https://doi.org/10.1007/s11064-006-9182-z

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