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Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania

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Abstract

Studies have demonstrated that oxidative stress is associated with amphetamine-induced neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain after amphetamine exposure. We studied the effects of acute and chronic amphetamine administration on superoxide dismutase (SOD) and catalase (CAT) activity, in a rodent model of mania. Male Wistar rats received either a single IP injection of d-amphetamine (1 mg/kg, 2 mg/kg, or 4 mg/kg) or vehicle (acute treatment). In the chronic treatment rats received a daily IP injection of either d-amphetamine (1 mg/kg, 2 mg/kg, or 4 mg/kg) or vehicle for 7 days. Locomotor behavior was assessed using the open field test. SOD and CAT activities were measured in the prefrontal cortex, hippocampus, and striatum. Acute and to a greater extent chronic amphetamine treatment increased locomotor behavior and affected SOD and CAT activities in the prefrontal cortex, hippocampus and striatum. Our findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum.

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Acknowledgements

This study was partly supported by CNPq, FAPESC, UNESC, and CAPES Foundation (Brazil).

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Authors and Affiliations

  1. Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil

    Benício N. Frey & Flávio Kapczinski

  2. Bipolar Disorders Program, Hospital de Clínicas de Porto Alegre, 90035-003, Porto Alegre, RS, Brazil

    Benício N. Frey & Flávio Kapczinski

  3. MOOD-CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA

    Benício N. Frey

  4. Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil

    Samira S. Valvassori, Gislaine Z. Réus, Márcio R. Martins & João Quevedo

  5. Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil

    Fabrícia C. Petronilho, Katrine Bardini & Felipe Dal-Pizzol

Authors
  1. Benício N. Frey
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  2. Samira S. Valvassori
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  3. Gislaine Z. Réus
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  4. Márcio R. Martins
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  5. Fabrícia C. Petronilho
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  6. Katrine Bardini
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  7. Felipe Dal-Pizzol
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  8. Flávio Kapczinski
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  9. João Quevedo
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Corresponding author

Correspondence to João Quevedo.

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Frey, B.N., Valvassori, S.S., Réus, G.Z. et al. Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania. Neurochem Res 31, 699–703 (2006). https://doi.org/10.1007/s11064-006-9070-6

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  • DOI: https://doi.org/10.1007/s11064-006-9070-6

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