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Taurine Interaction with Neurotransmitter Receptors in the CNS: An Update

Abstract

Taurine appears to have multiple functions in the brain participating both in volume regulation and neurotransmission. In the latter context it may exert its actions by serving as an agonist at receptors of the GABAergic and glycinergic neurotransmitter systems. Its interaction with GABAA and GABAB receptors as well as with glycine receptors is reviewed and the physiological relevance of such interactions is evaluated. The question as to whether local extracellular concentrations of taurine are likely to reach the threshold level for the pertinent receptor populations cannot presently be answered satisfactorily. Hence more sophisticated analytical methods are warranted in order to obtain a definite answer to this important question.

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References

  1. M. Palkovits I. Elekes T. Lang A. Patthy (1986) ArticleTitleTaurine levels in discrete brain nuclei of rats J. Neurochem. 47 1333–1335 Occurrence Handle3760864 Occurrence Handle1:CAS:528:DyaL28XmtF2msrs%3D

    PubMed  CAS  Google Scholar 

  2. M. Banay-Schwartz M. Palkovits A. Lajtha (1993) ArticleTitleHeterogeneous distribution of functionally important amino acids in brain areas of adult and aging humans Neurochem. Res. 18 417–423 Occurrence Handle8474566 Occurrence Handle10.1007/BF00967245 Occurrence Handle1:CAS:528:DyaK3sXit1Kgt7k%3D

    PubMed  Article  CAS  Google Scholar 

  3. T. S. Haugstadt E. Try Valo I. A. Langmoen (1995) ArticleTitleChanges in brain amino acid content induced by hyposmolar stress and energy deprivation Neurol. Res. 17 402–408

    Google Scholar 

  4. H. Pasantes-Morales (1996) ArticleTitleVolume regulation in brain cells: Cellular and molecular mechanisms Metab. Brain Dis. 11 187–204 Occurrence Handle8869940 Occurrence Handle10.1007/BF02237957 Occurrence Handle1:CAS:528:DyaK28Xlslylsr0%3D

    PubMed  Article  CAS  Google Scholar 

  5. T. J. Miller R. D. Hanson P. H. Yancey (2000) ArticleTitleDevelopmental changes in organic osmolytes in prenatal and postnatal rat tissues Comp. Biochem. Physiol. Part A 125 45–56 Occurrence Handle10.1016/S1095-6433(99)00160-9 Occurrence Handle1:STN:280:DC%2BD3c3ktlyrtQ%3D%3D

    Article  CAS  Google Scholar 

  6. I. Holopainen S. S. Oja K. M. Marnela P. Kontro (1986) ArticleTitleFree amino acids of rat astrocytes in primary culture: Changes during cell maturation Int. J. Dev. Neurosci. 4 493–496 Occurrence Handle3455607 Occurrence Handle1:CAS:528:DyaL28Xmt1entLo%3D Occurrence Handle10.1016/0736-5748(86)90031-6

    PubMed  CAS  Article  Google Scholar 

  7. H. Pasantes-Morales A. Schousboe (1988) ArticleTitleVolume regulation in astrocytes: A role for taurine as an osmoeffector J. Neurosci. Res. 20 505–509 Occurrence Handle1:CAS:528:DyaL1MXlt1Kr

    CAS  Google Scholar 

  8. M. N. Brookes (1993) ArticleTitleInteraction between the glutamine cycle and the uptake of large neutral amino acids in astrocytes J. Neurochem. 60 1923–1928 Occurrence Handle8097238 Occurrence Handle1:CAS:528:DyaK3sXisFajsrc%3D

    PubMed  CAS  Google Scholar 

  9. U. Wysmyk S. S. Oja P. Saransaari J. Albrecht (1994) ArticleTitleLong-term treatment with ammonia affects the content and release of taurine in cultured cerebellar astrocytes and granule neurons Neurochem. Int. 24 317–322 Occurrence Handle8061596 Occurrence Handle10.1016/0197-0186(94)90109-0 Occurrence Handle1:CAS:528:DyaK2cXktVarur0%3D

    PubMed  Article  CAS  Google Scholar 

  10. H. Pasantes-Morales A. Schousboe (1989) ArticleTitleRelease of taurine from astrocytes during potassium-evoked swelling Glia 2 45–50 Occurrence Handle2523338 Occurrence Handle10.1002/glia.440020105 Occurrence Handle1:STN:280:BiaB3M3nvFw%3D

    PubMed  Article  CAS  Google Scholar 

  11. H. Pasantes-Morales A. Schousboe (1997) ArticleTitleRole of taurine in osmoregulation in brain cells: Mechanisms and functional implications Amino Acids 12 281–292 Occurrence Handle10.1007/BF01373008 Occurrence Handle1:CAS:528:DyaK2sXkvFKgs7Y%3D

    Article  CAS  Google Scholar 

  12. S. Basavappa A. Mobasheri R. Errington C. C. Huang S. Al-Adawi J. C. Ellory (1998) ArticleTitleInhibition of Na+, K+-ATPase activates swelling-induced taurine efflux in a human neuroblastoma cell line J. Cell Physiol. 174 145–153 Occurrence Handle9428800 Occurrence Handle10.1002/(SICI)1097-4652(199802)174:2<145::AID-JCP1>3.0.CO;2-O Occurrence Handle1:CAS:528:DyaK1cXivFyltA%3D%3D

    PubMed  Article  CAS  Google Scholar 

  13. R. Franco O. Quesada H. Pasantes-Morales (2000) ArticleTitleEfflux of osmolyte amino acids during isovolumic regulation in hippocampal slices J. Neurosci. Res. 61 701–711 Occurrence Handle10972967 Occurrence Handle10.1002/1097-4547(20000915)61:6<701::AID-JNR14>3.0.CO;2-T Occurrence Handle1:CAS:528:DC%2BD3cXmsVygsbY%3D

    PubMed  Article  CAS  Google Scholar 

  14. P. Saransaari S. S. Oja (2000) ArticleTitleTaurine and neural cell damage Amino Acids 19 509–526 Occurrence Handle11140356 Occurrence Handle10.1007/s007260070003 Occurrence Handle1:CAS:528:DC%2BD3MXotFSqsw%3D%3D

    PubMed  Article  CAS  Google Scholar 

  15. H. Benveniste J. Drejer A. Schousboe N. H. Diemer (1984) ArticleTitleElevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis J. Neurochem. 43 1369–1374 Occurrence Handle6149259 Occurrence Handle1:CAS:528:DyaL2cXmt1yjt7k%3D

    PubMed  CAS  Google Scholar 

  16. N. Menendez J. M. Solis O. Herreras M. Galarreta C. Conejero R. Martin del Rio (1993) ArticleTitleTaurine release evoked by NMDA receptor activation is largely dependent on calcium mobilization from intracellular stores Eur. J. Neurosci. 5 1273–1279 Occurrence Handle8275229 Occurrence Handle1:STN:280:ByuC3c7islI%3D

    PubMed  CAS  Google Scholar 

  17. S. Shibanoki M. Kogure M. Sugahara K. Ishikawa (1993) ArticleTitleEffect of systemic administration of N-methyl-D-aspartic acid on extracellular taurine level measured by microdialysis in the hippocampal CA1 field and striatum of rats J. Neurochem. 61 1698–1704 Occurrence Handle7901330 Occurrence Handle1:CAS:528:DyaK2cXhtFKj

    PubMed  CAS  Google Scholar 

  18. G. Segovia A. Del Arco F. Mora (1997) ArticleTitleEndogenous glutamate increases extracellular concentrations of dopamine, GABA, and taurine through NMDA and AMPA/kainate receptors in striatum of the freely moving rat: a microdialysis study J. Neurochem. 69 1476–1483 Occurrence Handle9326276 Occurrence Handle1:CAS:528:DyaK2sXmsVCksL8%3D

    PubMed  CAS  Google Scholar 

  19. Y. Seki P. J. Feustel R. W. Keller SuffixJr. B. I. Tranmer H. K. Kimelberg (1999) ArticleTitleInhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker Stroke 30 433–440 Occurrence Handle9933284 Occurrence Handle1:CAS:528:DyaK1MXht1KmsLY%3D

    PubMed  CAS  Google Scholar 

  20. M. Zielińska W. Hilgier H. D. Borkowska S. S. Oja P. Saransaari J. Albrecht (2002) ArticleTitleMechanism of ammonia-induced taurine accumulation in the rat striatum in vivo Neurochem. Res. 27 37–42 Occurrence Handle11926274

    PubMed  Google Scholar 

  21. S. Molchanova S. S. Oja P. Saransaari (2004) ArticleTitleCharacteristics of basal taurine release in the rat striatum measured by microdialysis Amino Acids 27 261–268 Occurrence Handle15549491 Occurrence Handle10.1007/s00726-004-0139-8 Occurrence Handle1:CAS:528:DC%2BD2cXhtVGgt7jK

    PubMed  Article  CAS  Google Scholar 

  22. S. Ahmad L. J. Fowler P. S. Whitton (2005) ArticleTitleEffects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats Naunyn Schmiedebergs Arch. Pharmacol. 371 1–8 Occurrence Handle15660242 Occurrence Handle10.1007/s00210-004-1008-4 Occurrence Handle1:CAS:528:DC%2BD2MXhsFGjsrg%3D

    PubMed  Article  CAS  Google Scholar 

  23. P. Kontro S. S. Oja (1983) ArticleTitleSodium-independent taurine binding to brain synaptic membranes Cell Mol. Biochem. 3 183–187 Occurrence Handle1:CAS:528:DyaL2cXksFyltg%3D%3D

    CAS  Google Scholar 

  24. P. Kontro S. S. Oja (1987) ArticleTitleCo-operativity in sodium-independent taurine binding to brain membranes in the mouse Neuroscience 23 567–570 Occurrence Handle3437979 Occurrence Handle10.1016/0306-4522(87)90076-5 Occurrence Handle1:CAS:528:DyaL1cXkvFyjuw%3D%3D

    PubMed  Article  CAS  Google Scholar 

  25. B. A. McCool S. K. Botting (2000) ArticleTitleCharacterization of strychnine-sensitive glycine receptors in acutely isolated adult rat basolateral membranes Brain Res. 859 341–351 Occurrence Handle10719083 Occurrence Handle10.1016/S0006-8993(00)02026-6 Occurrence Handle1:CAS:528:DC%2BD3cXhsleqsro%3D

    PubMed  Article  CAS  Google Scholar 

  26. D. -S. Wang T. -L. Xu Z. -P. Pang J. -S. Li N. Akaike (1998) ArticleTitleTaurine-activated chloride currents in the rat dorsal commissural neurons Brain Res. 792 41–47 Occurrence Handle9593814 Occurrence Handle1:CAS:528:DyaK1cXivVCrs7s%3D

    PubMed  CAS  Google Scholar 

  27. M. Mori B. H. Gähwiler U. Gerber (2002) ArticleTitleBeta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro J. Physiol. 539 191–200 Occurrence Handle11850512 Occurrence Handle10.1113/jphysiol.2001.013147 Occurrence Handle1:CAS:528:DC%2BD38XislGnt7Y%3D

    PubMed  Article  CAS  Google Scholar 

  28. A. Dahchour E. Quertemont P. Witte ParticleDe (1996) ArticleTitleTaurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats Brain Res. 735 9–19 Occurrence Handle8905164 Occurrence Handle10.1016/0006-8993(96)00537-9 Occurrence Handle1:CAS:528:DyaK28XlvFCqtrs%3D

    PubMed  Article  CAS  Google Scholar 

  29. G. Martin G. R. Siggins (2002) ArticleTitleElectrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens J. Pharmacol. Exp. Therap. 302 1135–1145 Occurrence Handle10.1124/jpet.102.033399 Occurrence Handle1:CAS:528:DC%2BD38XmsF2htrc%3D

    Article  CAS  Google Scholar 

  30. Z. Jiang K. Krnjevic F. Wang J. H. Ye (2004) ArticleTitleTaurine activates strychnine-sensitive glycine receptors in neurons freshly isolated from nucleus accumbens of young rats J. Neurophysiol. 91 248–257 Occurrence Handle12878709 Occurrence Handle1:CAS:528:DC%2BD2cXht1aks7k%3D

    PubMed  CAS  Google Scholar 

  31. A. N. Chepkova N. Doreulee Y. Yanovsky D. Mukhopadhyay H. L. Haas O. A. Sergeeva (2002) ArticleTitleLong-lasting enhancement of cortocostriatal neurotransmission by taurine Eur. J. Neurosci. 16 1523–1530 Occurrence Handle12405966 Occurrence Handle10.1046/j.1460-9568.2002.02223.x Occurrence Handle1:STN:280:DC%2BD38nkslWjsA%3D%3D

    PubMed  Article  CAS  Google Scholar 

  32. O. A. Sergeeva A. N. Chepkova N. Doreulee K. S. Eriksson W. Poelchen I. Monnighoff B. Heller-Stilb U. Warskulat D. Haussinger H. L. Haas (2003) ArticleTitleTaurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters J.Physiology. 550 911–919 Occurrence Handle10.1113/jphysiol.2003.045864 Occurrence Handle1:CAS:528:DC%2BD3sXnslGitb4%3D

    Article  CAS  Google Scholar 

  33. A. N. Chepkova O. A. Sergeeva H. L. Haas (2005) ArticleTitleLong-lasting enhancement of corticostriatal transmission by taurine: role of dopamine and acetylcholine Cell Mol. Neurobiol. 25 767–776 Occurrence Handle16075390 Occurrence Handle10.1007/s10571-005-3974-6 Occurrence Handle1:CAS:528:DC%2BD2MXnslyqsr0%3D

    PubMed  Article  CAS  Google Scholar 

  34. P. Wahl L. Elster A. Schousboe (1994) ArticleTitleIdentification and function of glycine receptors in cultured cerebellar granule cells J. Neurochem. 62 2457–2463 Occurrence Handle7910635 Occurrence Handle1:CAS:528:DyaK2cXktVWktrw%3D

    PubMed  CAS  Google Scholar 

  35. H. Inomata J. Nabekura N. Akaike (1993) ArticleTitleSuppression of taurine response in acutely dissociated substantia nigra neurons by intracellular cyclic AMP Brain Res. 615 347–350 Occurrence Handle8395961 Occurrence Handle10.1016/0006-8993(93)90048-R Occurrence Handle1:CAS:528:DyaK3sXltlaisbY%3D

    PubMed  Article  CAS  Google Scholar 

  36. J. Nabekura N. Omura N. Akaike (1996) ArticleTitle2 adrenoceptor potentiates glycine receptor-mediated taurine response through protein kinase A in rat substantia nigra neurons J. Neurophysiol. 76 2447–2454 Occurrence Handle8899617 Occurrence Handle1:CAS:528:DyaK28XmvFKgtro%3D

    PubMed  CAS  Google Scholar 

  37. J. Nabekura N. Omura T. Horimoto N. Ogawa N. Akaike (1996) ArticleTitleAlpha 1 adrenoceptor activation potentiates taurine response mediated by protein kinase C in substantia nigra neurons J. Neurophysiol. 76 2455–2460 Occurrence Handle8899618 Occurrence Handle1:STN:280:ByiD2MrjtlU%3D

    PubMed  CAS  Google Scholar 

  38. K. Yu S. Ge D. Ruan (2003) ArticleTitleFe2+ decreases the taurine-induced Cl- current in acutely dissociated rat hippocampal neurons Brain Res. 960 25–35 Occurrence Handle12505654 Occurrence Handle10.1016/S0006-8993(02)03736-8 Occurrence Handle1:CAS:528:DC%2BD38XpslSnurY%3D

    PubMed  Article  CAS  Google Scholar 

  39. J. S. Farroni B. A. McCool (2004) ArticleTitleExtrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors BMC Pharmacol. 4 16 Occurrence Handle15301692 Occurrence Handle10.1186/1471-2210-4-16 Occurrence Handle1:CAS:528:DC%2BD2cXnslSlt7o%3D

    PubMed  Article  CAS  Google Scholar 

  40. N. Hussy C. Deleuze A. Pantaloni M. G. Desarmenien F. Moos (1997) ArticleTitleAgonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation J. Physiology. 502 609–621 Occurrence Handle10.1111/j.1469-7793.1997.609bj.x Occurrence Handle1:CAS:528:DyaK2sXlsF2qtL4%3D

    Article  CAS  Google Scholar 

  41. C. Decavel G. I. Hatton (1995) ArticleTitleTaurine immunoreactivity in the rat supraoptic nucleus: prominent localization in glial cells J. Comp. Neurol. 354 13–26 Occurrence Handle7615871 Occurrence Handle10.1002/cne.903540103 Occurrence Handle1:CAS:528:DyaK2MXkvF2mur4%3D

    PubMed  Article  CAS  Google Scholar 

  42. N. Hussy V. Bres M. Rochette A. Duvoid G. Alonso G. Dayanithi F. C. Moos (2001) ArticleTitleOsmoregulation of vasopressin secretion via activation of neurohypophysial nerve terminals glycine receptors by glial taurine J. Neurosci. 21 7110–7116 Occurrence Handle11549721 Occurrence Handle1:CAS:528:DC%2BD3MXmvFWhtbs%3D

    PubMed  CAS  Google Scholar 

  43. C. Deleuze G. Alonso I. A. Lefevre A. Duvoid-Guillou N. Hussy (2005) ArticleTitleExtrasynaptic localization of glycine receptors in the rat supraoptic nucleus: further evidence for their involvement in glia-to-neuron communication Neuroscience 133 175–183 Occurrence Handle15893641 Occurrence Handle10.1016/j.neuroscience.2005.01.060 Occurrence Handle1:CAS:528:DC%2BD2MXktVOltbc%3D

    PubMed  Article  CAS  Google Scholar 

  44. A. C. Flint X. Liu A. R. Kriegstein (1998) ArticleTitleNonsynaptic glycine receptor activation during early neocortical development Neuron. 20 43–53 Occurrence Handle9459441 Occurrence Handle10.1016/S0896-6273(00)80433-X Occurrence Handle1:CAS:528:DyaK1cXnvVSlug%3D%3D

    PubMed  Article  CAS  Google Scholar 

  45. M. H. Bureau R. W. Olsen (1993) ArticleTitleGABAA receptor subtypes: ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography J. Neurochem. 61 1479–1491 Occurrence Handle8397295 Occurrence Handle1:CAS:528:DyaK3sXms1eitLo%3D

    PubMed  CAS  Google Scholar 

  46. M. R. Quinn C. L. Miller (1992) ArticleTitleTaurine allosterically modulates flunitrazepam binding to synaptic membranes J. Neurosci. Res. 33 136–141 Occurrence Handle1453477 Occurrence Handle10.1002/jnr.490330117 Occurrence Handle1:CAS:528:DyaK38XmtVGjuro%3D

    PubMed  Article  CAS  Google Scholar 

  47. M. R. Quinn C. L. Harris (1995) ArticleTitleTaurine allosterically inhibits binding of [35S]-t-butylbicyclophosphorothionate (TBPS) to rat brain synaptic membranes Neuropharmacology 34 1607–1613 Occurrence Handle8788958 Occurrence Handle10.1016/0028-3908(95)00118-2 Occurrence Handle1:CAS:528:DyaK28XhvFGkug%3D%3D

    PubMed  Article  CAS  Google Scholar 

  48. C. Dominguez-Perrot P. Feltz M. O. Poulter (1996) ArticleTitleRecombinant GABAA receptor desensitization : the role of the gamma 2 subunit and its physiological significance J. Physiol. 497 145–159 Occurrence Handle8951718 Occurrence Handle1:CAS:528:DyaK28XnsV2iurk%3D

    PubMed  CAS  Google Scholar 

  49. W. Shen S. Mennerick D. F. Covey C. F. Zorumski (2000) ArticleTitlePregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA A receptor desensitization J. Neurosci. 20 3571–3579 Occurrence Handle10804198 Occurrence Handle1:CAS:528:DC%2BD3cXjtlKqs74%3D

    PubMed  CAS  Google Scholar 

  50. N. Del Olmo J. Bustamante R. M. Del Rio J. M. Solis (2000) ArticleTitleTaurine activates GABA A but not GABA B receptors in rat hippocampal CA1 area Brain Res. 864 298–307 Occurrence Handle10802037 Occurrence Handle10.1016/S0006-8993(00)02211-3 Occurrence Handle1:CAS:528:DC%2BD3cXivVGgs7Y%3D

    PubMed  Article  CAS  Google Scholar 

  51. O. A. Sergeeva H. L. Haas (2001) ArticleTitleExpression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse Neuroscience 104 1043–1055 Occurrence Handle11457589 Occurrence Handle10.1016/S0306-4522(01)00130-0 Occurrence Handle1:CAS:528:DC%2BD3MXlt1Sit7o%3D

    PubMed  Article  CAS  Google Scholar 

  52. G. Ye A. C. Tse W. Yung (1997) ArticleTitleTaurine inhibits rat substantia nigra pars reticulata neurons by activation of GABA- and glycine-linked chloride conductance Brain Res. 749 175–179 Occurrence Handle9070647 Occurrence Handle10.1016/S0006-8993(96)01427-8 Occurrence Handle1:CAS:528:DyaK2sXpt12htg%3D%3D

    PubMed  Article  CAS  Google Scholar 

  53. M. Puopolo I. Kratskin O. Beluzzi (1998) ArticleTitleDirect inhibitory effect of taurine on relay neurones of the rat olfactory bulb in vitro Neuroreport 9 2319–2323 Occurrence Handle9694221 Occurrence Handle1:CAS:528:DyaK1cXltVKlt78%3D

    PubMed  CAS  Google Scholar 

  54. O. Belluzzi M. Puopolo M. Benedusi I. Kratskin (2004) ArticleTitleSelective neuroinhibitory effects of taurine in slices of rat main olfactory bulb Neuroscience 124 929–944 Occurrence Handle15026133 Occurrence Handle10.1016/j.neuroscience.2003.12.032 Occurrence Handle1:CAS:528:DC%2BD2cXitFCjurw%3D

    PubMed  Article  CAS  Google Scholar 

  55. Z. Song G. I. Hatton (2003) ArticleTitleTaurine and the control of basal hormone release from rat neurohypophysis Exp. Neurol. 183 330–337 Occurrence Handle14552874 Occurrence Handle10.1016/S0014-4886(03)00105-5 Occurrence Handle1:CAS:528:DC%2BD3sXnvVykt70%3D

    PubMed  Article  CAS  Google Scholar 

  56. A. Martinez-Torres R. Miledi (2004) ArticleTitleExpression of functional receptors by the human gamma-aminobutyric acid A gamma 2 subunit Proc. Natl. Acad. Sci. US 101 3220–3223 Occurrence Handle10.1073/pnas.0308682101 Occurrence Handle1:CAS:528:DC%2BD2cXitlWhtbY%3D

    Article  CAS  Google Scholar 

  57. A. A. Boldyrev P. Johnson Y. Wei Y. Tan D. O. Carpenter (1999) ArticleTitleCarnosine and taurine protect rat cerebellar granular cells from free radical damage Neurosci. Lett. 263 169–172 Occurrence Handle10213162 Occurrence Handle10.1016/S0304-3940(99)00150-0 Occurrence Handle1:CAS:528:DyaK1MXitlKis78%3D

    PubMed  Article  CAS  Google Scholar 

  58. A. El Idrissi E. Trenkner (1999) ArticleTitleGrowth factors and taurine againts excitotoxicity by stabilizing calcium homeostasis and energy metabolism J. Neurosci. 19 9459–9468 Occurrence Handle10531449 Occurrence Handle1:CAS:528:DyaK1MXnslyiurk%3D

    PubMed  CAS  Google Scholar 

  59. P. Zhao Y. L. Huang J. S. Chen (1999) ArticleTitleTaurine antagonizes calcium overload induced by glutamate or chemical hypoxia in cultured rat hippocampal neurons Neurosci. Lett. 268 25–28 Occurrence Handle10400069 Occurrence Handle10.1016/S0304-3940(99)00373-0 Occurrence Handle1:CAS:528:DyaK1MXjs1SgtrY%3D

    PubMed  Article  CAS  Google Scholar 

  60. P. R. Louzada A. C. P. Lima D. L. Mendonca-Silva F. Noel F. G. Mello Particlede S. T. Ferreira (2004) ArticleTitleTaurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disorders FASEB J. 18 511–518 Occurrence Handle15003996 Occurrence Handle10.1096/fj.03-0739com Occurrence Handle1:CAS:528:DC%2BD2cXisFWks7s%3D

    PubMed  Article  CAS  Google Scholar 

  61. M. B. O‘Byrne K. F. Tipton (2000) ArticleTitleTaurine-induced attenuation of MPP+ neurotoxicity in vitro: a possible role for the GABA A subclass of GABA receptors J. Neurochem. 74 2087–2093 Occurrence Handle10800953 Occurrence Handle1:CAS:528:DC%2BD3cXis12ru74%3D

    PubMed  CAS  Google Scholar 

  62. M. Zielińska R. O. Law J. Albrecht (2003) ArticleTitleExcitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia Neurochem. Int. 43 299–303 Occurrence Handle12742072

    PubMed  Google Scholar 

  63. J. H. Abraham A. Schousboe (1989) ArticleTitleEffects of taurine on cell morphology and expression of low-affinity GABA receptors in cultured cerebellar granule cells Neurochem. Res. 14 1031–1038 Occurrence Handle2558322 Occurrence Handle10.1007/BF00965939 Occurrence Handle1:CAS:528:DyaK3cXjtFSlug%3D%3D

    PubMed  Article  CAS  Google Scholar 

  64. W. Hilgier S. S. Oja P. Saransaari J. Albrecht (2005) ArticleTitleTaurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors Brain Res. 1043 242–246 Occurrence Handle15862540 Occurrence Handle10.1016/j.brainres.2005.02.066 Occurrence Handle1:CAS:528:DC%2BD2MXjs1GjsLc%3D

    PubMed  Article  CAS  Google Scholar 

  65. A. Lehmann J. W. Lazarewicz M. Zeise (1985) ArticleTitleN-methylaspartate-evoked liberation of taurine and phosphoethanolamine in vivo: site of release J. Neurochem. 45 1172–1177 Occurrence Handle3897458 Occurrence Handle1:CAS:528:DyaL2MXlvFWjsLo%3D

    PubMed  CAS  Google Scholar 

  66. D. Scheller M. Korte S. Szathmary F. Tegtmeier (2000) ArticleTitleCerebral taurine release mechanisms in vivo: pharmacological investigations in rats using microdialysis for proof of principle Neurochem. Res. 25 801–807 Occurrence Handle10943998 Occurrence Handle10.1023/A:1007513423270 Occurrence Handle1:CAS:528:DC%2BD3cXlt1ajs7g%3D

    PubMed  Article  CAS  Google Scholar 

  67. V. L. R. Rao R. M. Audet R. F. Butterworth (1995) ArticleTitleSelective alterations of extracellular brain amino acids in relation to function in experimental portal-systemic encephalopathy: Results of an in vivo microdialysis study J. Neurochem. 65 1221–1228 Occurrence Handle7643101 Occurrence Handle1:CAS:528:DyaK2MXns1eisrs%3D

    PubMed  CAS  Google Scholar 

  68. W. Hilgier E. Anderzhanova S. S. Oja P. Saransaari J. Albrecht (2003) ArticleTitleTaurine reduces ammonia- and N-methyl-D-aspartate-induced accumulation of cyclic GMP and hydroxyl radicals in microdialysates of the rat striatum Eur. J. Pharmacol. 468 21–25 Occurrence Handle12729839 Occurrence Handle10.1016/S0014-2999(03)01667-4 Occurrence Handle1:CAS:528:DC%2BD3sXjt1Kgtb0%3D

    PubMed  Article  CAS  Google Scholar 

  69. J. Albrecht A. S. Bender M. D. Norenberg (1994) ArticleTitleAmmonia stimulates the release of taurine from cultured astrocytes Brain Res. 660 228–232 Occurrence Handle10.1016/0006-8993(94)91301-3

    Article  Google Scholar 

  70. L. Faff-Michalak A. Reichenbach D. Dettmer K. Kellner J. Albrecht (1994) ArticleTitleK+, -Hypoosmolarity-, and NH4+ -induced taurine release from cultured rabbit Müller cells: Role of Na+ and Cl- ions and relation to cell volume changes Glia 10 114–120 Occurrence Handle8168865 Occurrence Handle10.1002/glia.440100205 Occurrence Handle1:STN:280:ByuB383ksFM%3D

    PubMed  Article  CAS  Google Scholar 

  71. L. Faff A. Reichenbach J. Albrecht (1996) ArticleTitleAmmonia-induced taurine release from cultured rabbit Muller cells is an osmoresistant process mediated by intracellular accumulation of cyclic AMP J. Neurosci. Res. 46 231–238 Occurrence Handle8915900 Occurrence Handle1:CAS:528:DyaK28Xms1anurk%3D

    PubMed  CAS  Google Scholar 

  72. L. Faff A. Reichenbach J. Albrecht (1997) ArticleTitleTwo modes of stimulation by ammonia of taurine release from cultured rabbit Muller cells Neurochem. Int. 31 301–305 Occurrence Handle9220463 Occurrence Handle10.1016/S0197-0186(96)00126-X Occurrence Handle1:CAS:528:DyaK2sXksFahsLY%3D

    PubMed  Article  CAS  Google Scholar 

  73. M. Zielińska W. Hilgier R. O. Law P. Goryński J. Albrecht (1999) ArticleTitleEffects of ammonia in vitro on endogenous taurine efflux and cell volume in rat cerebrocortical minislices: influence of inhibitors of volume-sensitive amino acid transport Neuroscience 91 631–638 Occurrence Handle10366020

    PubMed  Google Scholar 

  74. P. Kontro S. S. Oja (1990) ArticleTitleInteractions of taurine with GABA-B binding sites in mouse brain Neuropharmacology 29 243–247 Occurrence Handle2158001 Occurrence Handle10.1016/0028-3908(90)90008-F Occurrence Handle1:CAS:528:DyaK3cXhvFagu7o%3D

    PubMed  Article  CAS  Google Scholar 

  75. S. S. Smith J. Li (1991) ArticleTitleGABA B receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neoanatal rat cerebellum Neurosci. Lett. 132 59–64 Occurrence Handle1686306 Occurrence Handle10.1016/0304-3940(91)90433-T Occurrence Handle1:CAS:528:DyaK38Xlt1SntA%3D%3D

    PubMed  Article  CAS  Google Scholar 

  76. J. M. Fritschy V. Meskenaite O. Weinmann M. Honer D. Benke H. Mohler (1999) ArticleTitleGABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization Eur. J. Neurosci. 11 761–768 Occurrence Handle10103070 Occurrence Handle10.1046/j.1460-9568.1999.00481.x Occurrence Handle1:STN:280:DyaK1M3gtlejsQ%3D%3D

    PubMed  Article  CAS  Google Scholar 

  77. I. Mody (2001) ArticleTitleDistinguishing between GABA(A) receptors responsible for tonic and phasic conductances Neurochem. Res. 26 907–913 Occurrence Handle11699942 Occurrence Handle10.1023/A:1012376215967 Occurrence Handle1:CAS:528:DC%2BD3MXnvF2itrs%3D

    PubMed  Article  CAS  Google Scholar 

  78. A. Schousboe O. M. Larsson A. Sarup H. S. White (2004) ArticleTitleRole of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy Eur. J. Pharmacol. 500 281–287 Occurrence Handle15464040 Occurrence Handle10.1016/j.ejphar.2004.07.032 Occurrence Handle1:CAS:528:DC%2BD2cXotFClu7c%3D

    PubMed  Article  CAS  Google Scholar 

  79. E. Fedele M. A. Ansaldo G. Varnier M. Raiteri (2000) ArticleTitleBenzodiazepine-sensitive GABAA receptors limit the activity of the NMDA/NO/cyclic GMP pathway: a microdialysis study in the cerebellum of freely moving rats J. Neurochem. 75 782–787 Occurrence Handle10899955 Occurrence Handle10.1046/j.1471-4159.2000.0750782.x Occurrence Handle1:CAS:528:DC%2BD3cXltFCltbg%3D

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Jan Albrecht.

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Special issue dedicated to Dr. Simo S. Oja

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Albrecht, J., Schousboe, A. Taurine Interaction with Neurotransmitter Receptors in the CNS: An Update. Neurochem Res 30, 1615–1621 (2005). https://doi.org/10.1007/s11064-005-8986-6

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Key words

  • Taurine
  • GABAA receptor
  • GABAB receptor
  • glycine receptor