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Effects of Physical Training in Different Modes on Cognitive Function and GNDF Level in Old Mice

We compared the effects of physical high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the cognitive functions in old mice and on serum levels of glial cell line-derived neurotrophic factor (GDNF) in these animals. Thirty old (aged 22 months) mice were divided into control (no training), MICT, and HIIT groups; the training protocol (treadmill running) was applied for 8 weeks. The spontaneous alternation test (Y-maze) and inhibitory avoidance test were used to assess cognitive function. The GDNF levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Both HIIT and MICT cycles improved cognitive functions compared to those in the control group; HIIT provided a greater improvement than MICT, and this difference was significant in the inhibitory avoidance test. Both training cycles increased the serum GDNF level compared with the control group; however, this increase was greater in the HIIT group. Thus, both HIIT and MICT could improve cognitive functions in old mice and increase the serum GNDF level, but HIIT seems to provide greater beneficial effects by resulting in a greater increase in the amount of this neurotrophic factor.

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Sarvat, S., Sabaghi, A., Yosofvand, N. et al. Effects of Physical Training in Different Modes on Cognitive Function and GNDF Level in Old Mice. Neurophysiology 53, 132–139 (2022).

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  • old mice
  • physical high-intensity interval training (HIIT)
  • moderate-intensity continuous training (MICT)
  • cognitive function
  • alteration and avoidance tests
  • GDNF