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Neurophysiological and Neuropsychological Analysis of the Cognitive Functions in Dysthyroid Female Patients

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Neurophysiology Aims and scope

The P300 potential was recorded in 29 newly diagnosed hypothyroid and 29 newly diagnosed hyperthyroid female patients using a standard odd-ball paradigm of the acoustic stimuli. Cognitive functions were further assessed in these groups using the color trails test, triads test, and digit vigilance test. Similar procedures were repeated in 29 age- and education-matched normal euthyroid women. All the tests showed statistically significant differences (P < 0.05) in hypothyroid patients compared to the controls. The color trails test showed statistically significant differences between normal and hyperthyroid individuals. There were also statistically significant differences between hyperthyroid and hypothyroid individuals in all tests. Thus, a clear cognitive decline was observed in hypothyroid patients. This can be detected electrophysiologically, as well as by appropriate cognitive functional tests. Early detection and intervention may prevent further cognitive decline. Hyperthyroid individuals were found to show slower information processing, as compared to euthyroid individuals.

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Authors and Affiliations

  1. Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, India

    P. Mishra & B. L. Preethi

  2. Department of Endocrinology, M. S. Ramaiah Medical College, Bengaluru, India

    P. Kalra

Authors
  1. P. Mishra
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  2. B. L. Preethi
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  3. P. Kalra
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Correspondence to B. L. Preethi.

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Mishra, P., Preethi, B.L. & Kalra, P. Neurophysiological and Neuropsychological Analysis of the Cognitive Functions in Dysthyroid Female Patients. Neurophysiology 50, 183–188 (2018). https://doi.org/10.1007/s11062-018-9735-1

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  • DOI: https://doi.org/10.1007/s11062-018-9735-1

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