, Volume 49, Issue 6, pp 453–457 | Cite as

Effects of Memantine on Behavioral Indices of Rats in the Open Field

  • Yu. M. Tyshchenko
  • E. A. Lukyanetz

Effects of course (5 days) peroral introductions of memantine on behavioral indices of rafts in the open field test were examined. Ten animals were divided into two groups, control and experimental; rats of the latter group obtained five everyday introductions of 20 mg/kg memantine hydrochloride. Animals of the experimental group demonstrated more intense orientational/research activity (number of rearings) and significantly greater number of goings to the arena center. The dynamics of nearly all indices shown by rats of the two groups were dissimilar; memantine noticeably modified the structure of grooming behavior. Behavioral patterns in the open field allow one to conclude that memantine induces significant decreases in the levels of anxiety and fear. In general, effects of this agent can be characterized as adaptational/stimulatory ones. [1, 2]


open field memantine behavioral/emotional indices dementia rats 


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  1. 1.
    Kh. Yu. Ismailova, T. M. Agayev, and T. P. Semenova, Individual Peculiarities of Behavior (Monoaminergic Mechanisms), Nurlan, Baku (2007).Google Scholar
  2. 2.
    V. I. Rodina, N. A. Krupina, G. N. Kryzhanovskii, and N. B. Oknina, “A novel technique of estimation of the anxiety/phobic states in rats,” Zh. Vyssh. Nerv. Deyat., 43, No. 5, 1006–1017 (1993).Google Scholar
  3. 3.
    Z. A. Kruchenko, V. A. Gorbachenko, I. S. Chereda, et al., “Effect of memantine on motor behavioral phenomena in rats of different ages,” Neurophysiology, 46, 448–451 (2014).CrossRefGoogle Scholar
  4. 4.
    V. Gorbachenko, I. Chereda, S. Vrublevsky, et al., “Development and testing of the experimental system for registration of food reflex in rats,” Bull. Taras Shevchenko Natl. Univ. Kyiv Ser. Radiophys. Electron., 1/2, 31-33 (2014).Google Scholar
  5. 5.
    V. A. Gorbachenko, J. O. Kruchenko, I. S. Chereda, et al., “Measurements of the time parameters of conditioned food reflex in rats under memantine treatment using the automatic registration system,” Bull. Taras Shevchenko Natl. Univ. Kyiv. Ser. Radiophys. Electron., 1, 23-26 (2015).Google Scholar
  6. 6.
    J. Bureš, O. Burešova, and J. P. Huston, Techniques and Basic Experiments for the Study of Brain and Behavior [in Russian], Vyssh. Shkola, Moscow (1991).Google Scholar
  7. 7.
    D. A. Kulagin and V. N. Fedorov, “Study of emotionality in Wistar and Krushinskii–Molodkina rats in the open field test,” in Genetics of Behavior, Nauka, Leningrad (1969).Google Scholar
  8. 8.
    M. Wohrand and M. L. Scattoni, “Behavioural methods used in rodent models of autism spectrum disorders: current standards and new developments,” Behav. Brain Res., 251, 5-17 (2013).CrossRefGoogle Scholar
  9. 9.
    I. P. Zapadnyuk, V. I. Zapadnyuk, and Ye. A. Zakhariya, Laboratory Animals: Breeding, Keeping, and Using in Experiments, Vyshcha Shkola, Kyiv (1983).Google Scholar
  10. 10.
    A. V. Korosov and V. V. Gorbach, Computer Processing of Biological Data, Publ. House of the PetrSU, Petrozavodsk (2007).Google Scholar
  11. 11.
    N. A. Plokhinskii, Biometry, Publ. House of the MSU, Moscow (1970).Google Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Bogomolets Institute of Physiology of the NAS of UkraineKyivUkraine

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