, Volume 49, Issue 1, pp 53–58 | Cite as

Short- and Long-Term Effects of Methylphenidate on Cost-Benefit Decision Making in Adult Rats

  • S. Daniali
  • H. Manaheji
  • V. Nazemian
  • M. Taheri

Decision making is one of the most complicated and controversial topics in neuroscience. Today, there are important classes of chemicals that increase cognitive performance; in particular these are psychostimulants (e.g., methylphenidate, MPH). However, the long-term effects of MPH on cost-benefit decision making in healthy animals remain unknown. Therefore, we aimed to compare the short- and long-term effects of MPH in adult healthy male rats on the decision making in two distinct T-maze tasks and the ability of the animals to adjust the height of the obstacle in a T-maze or to process information on the reward amount. We found that short-term effects of MPH (2 weeks) played a significant role in making the correct decision in T-maze tasks, while the respective effects of long-term administration (12 weeks) were much weaker. These data suggest that chronic application of MPH has short- but not long-term effects on cost-benefit decision making in healthy adult animals.


methylphenidate (MPH) T-maze cost-benefit decision making cognitive performance 


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • S. Daniali
    • 1
    • 2
  • H. Manaheji
    • 1
    • 2
  • V. Nazemian
    • 1
    • 2
  • M. Taheri
    • 3
  1. 1.Neurophysiology Research CenterShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Physiology, School of MedicineShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Department of Anesthesiology, Imam Hosein HospitalShahid Beheshti University of Medical SciencesTehranIran

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