, Volume 48, Issue 6, pp 414–420 | Cite as

Parameters of the P300 Potential in Mild Neurocognitive Disorders of Different Etiologies

  • O. V. LevadaEmail author
  • N. V. Cherednichenko
  • S. V. Gorbachev

The latency and amplitude of the auditory evoked Р300 potential were measured in 25 elderly and old persons without any cognitive impairments (control group), 32 patients with mild neurocognitive disorder induced by Alzheimer’s disease (AD MNCD), and 33 patients with analogous impairment of subcortical vascular genesis (SCV MNCD). The examined groups did not differ from each other significantly in age, sex, and educational level. It was found that the mean latency of the Р300 wave in patients suffering from SCV MNCD (507.9 ± 203.6 msec) was significantly longer as compared with the analogous parameter in two other groups. The value of such increment allows one to differentiate SCV MNCD from the groups without cognitive impairment (326.9 ± 103.6 msec, Р = 0.00005) and AD MNCD (378.9 ± 99.9 msec Р = 0.0007). The increased P300 latency is related to the severity and clinical specificity of SCV MNCD and reflects a crucial influence of the microvascular cerebral frontosubcortical injury on the generation of this neurophysiological phenomenon. We conclude that the level of increase in the latency of wave Р300 can be used as a valid neurophysiological marker for differential diagnostics of MNCDs of the main etiological types.


mild neurocognitive disorders (MNCDs) evoked auditory Р300 potential latency amplitude 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Diagnostic and Statistical Manual of Mental Disorders, Am. Psychiat. Assoc., Arlington (2013).Google Scholar
  2. 2.
    R. C. Petersen, G. E. Smith, S. C. Waring, et al., “Aging, memory, and mild cognitive impairment,” Int. Psychogeriat., 9 , Suppl. 1, 65-69 (1997).CrossRefGoogle Scholar
  3. 3.
    R. C. Petersen, B. Caracciolo, C. Brayne, et al., “Mild cognitive impairment: a concept in evolution,” J. Int. Med., 275, No. 3, 214-228 (2014).CrossRefGoogle Scholar
  4. 4.
    E. M. Ebly, D. B. Hogan, and I. M. Parhad, “Cognitive impairment in the nondemented elderly: results from the Canadian study of health and aging,” Arch. Neurol., 52, No. 1, 37-42 (1995).Google Scholar
  5. 5.
    K. Ritchie, S. Artero, and J. Touchon, “Classification criteria for mild cognitive impairment: a populationbased validation study,” Neurology, 56, No. 1, 37-42 (2001).CrossRefPubMedGoogle Scholar
  6. 6.
    H. Jacqmin-Gadda, A. Alperovitch, C. Montlahuc, et al., “20-Year prevalence projections for dementia and impact of preventive policy about risk factors,” Eur. J. Epidemiol., 28, No. 6, 493-502 (2013).CrossRefPubMedGoogle Scholar
  7. 7.
    Y. Cheng and S. Xiao, “Recent research about mild cognitive impairment in China,” Shanghai Arch. Psychiat., 26, No. 1, 4-14 (2014).Google Scholar
  8. 8.
    H. Ishii, K. Meguro, S. Yamaguchi, et al., “Prevalence and cognitive performances of vascular cognitive impairment on dementia in Japan: the Osaki-Tajiri Project,” Eur. J. Neurol., 14, No. 6, 609-616 (2007).CrossRefPubMedGoogle Scholar
  9. 9.
    R. V. Pedroso, F. J. Fraga, D. I. Corazza, et al., “P300 latency and amplitude in Alzheimer’s disease: a systematic review,” Braz. J. Otorhinolaryngol., 78, No. 4, 126-132 (2012).CrossRefPubMedGoogle Scholar
  10. 10.
    O. A. Levada, A. V. Trailin, A. L. Kvitka, and O. V. Stolbinskaia, “P300 potential parameters at the stages of formation of the subcortical vascular dementia in elderly,” Lik. Sprava, Nos. 1/2, 60-66 (2014).Google Scholar
  11. 11.
    T. W. Picton, “The P300 wave of the human eventrelated potential,” J. Clin. Neurophysiol., 9, 456-479 (1992).CrossRefPubMedGoogle Scholar
  12. 12.
    B. F. O’Donnell, S. F. Faux, R. W. McCarley, et al., “Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process,” Arch. Gen. Psychiat., 52, 544-549 (1995).CrossRefPubMedGoogle Scholar
  13. 13.
    M. A. Parra, L. L. Ascencio, H. F. Urquina, et al., “P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia,” Front. Neurol., 3, 172 (2012).CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    T. Frodl, H. Hampel, G. Juckel, et al., “Value of eventrelated P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer’s disease,” Psychophysiology, 39, 175-181 (2001).CrossRefGoogle Scholar
  15. 15.
    E. J. Golob, J. K. Johnson, and A. Starr, “Auditory eventrelated potentials during target detection are abnormal in mild cognitive impairment,” Clin. Neurophysiol., 113, 151-161 (2002).CrossRefPubMedGoogle Scholar
  16. 16.
    E. J. Golob, R. Irimajiri, and A. Starr, “Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia,” Brain, 130, 740-752 (2007).CrossRefPubMedGoogle Scholar
  17. 17.
    G. B. Frisoni, S. Galluzzi, L. Bresciani, et al., “Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome,” J. Neurol., 249, No. 10, 1423-1432 (2002).CrossRefPubMedGoogle Scholar
  18. 18.
    M. F. Folstein, S. E. Folstein, and P. R. McHugh, “Minimental state: a practical method for grading the cognitive state of patients for the clinician,” J. Psychiat. Res., 12, 189-198 (1975).CrossRefPubMedGoogle Scholar
  19. 19.
    M. R. Schoenberg and J. G. Scott, The Little Black Book of Neuropsychology, Springer Science+Business Media, LLC (2011).Google Scholar
  20. 20.
    D. J. Libon, R. A. Swenson, E. J. Barnoski, and L. P. Sands, “Clock drawing as an assessment tool for dementia,” Arch. Clin. Neuropsychol., 8, 405-415 (1993).CrossRefPubMedGoogle Scholar
  21. 21.
    J. G. Borkowski, A. L. Benton, and O. Spreen, “Word fluency and brain damage,” Neuropsychology, 5, 135-140 (1967).CrossRefGoogle Scholar
  22. 22.
    J. L. Cummings, M. Mega, K. Gray, et al., “The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia,” Neurology, 44, 2308-2314 (1994).CrossRefPubMedGoogle Scholar
  23. 23.
    Z. Katsarou, S. Bostantjopoulou, V. Kimiskidis, et al., “Auditory event-related potentials in Parkinson’s disease in relation to cognitive ability,” Precept. Mot. Skills, 98, 1441-1448 (2004).CrossRefGoogle Scholar
  24. 24.
    F. Vecchio and S. Määttä, “The use of auditory eventrelated potentials in Alzheimer’s disease diagnosis,” Int. J. Alzheimer’s Disease, 2011, Article ID 653173, 7 P, doi:10.4061/2011/653173 (2011).Google Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • O. V. Levada
    • 1
    Email author
  • N. V. Cherednichenko
    • 1
    • 2
  • S. V. Gorbachev
    • 3
  1. 1.Zaporizhzhya Medical Academy of Postgraduate Education, Ministry of Public Health of UkraineZaporizhzhyaUkraine
  2. 2.Central Hospital of the Communar DistrictZaporizhzhyaUkraine
  3. 3.Zaporozhzhya State Medical UniversityZaporizhzhyaUkraine

Personalised recommendations