Parameters of the P300 Potential in Mild Neurocognitive Disorders of Different Etiologies
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The latency and amplitude of the auditory evoked Р300 potential were measured in 25 elderly and old persons without any cognitive impairments (control group), 32 patients with mild neurocognitive disorder induced by Alzheimer’s disease (AD MNCD), and 33 patients with analogous impairment of subcortical vascular genesis (SCV MNCD). The examined groups did not differ from each other significantly in age, sex, and educational level. It was found that the mean latency of the Р300 wave in patients suffering from SCV MNCD (507.9 ± 203.6 msec) was significantly longer as compared with the analogous parameter in two other groups. The value of such increment allows one to differentiate SCV MNCD from the groups without cognitive impairment (326.9 ± 103.6 msec, Р = 0.00005) and AD MNCD (378.9 ± 99.9 msec Р = 0.0007). The increased P300 latency is related to the severity and clinical specificity of SCV MNCD and reflects a crucial influence of the microvascular cerebral frontosubcortical injury on the generation of this neurophysiological phenomenon. We conclude that the level of increase in the latency of wave Р300 can be used as a valid neurophysiological marker for differential diagnostics of MNCDs of the main etiological types.
Keywordsmild neurocognitive disorders (MNCDs) evoked auditory Р300 potential latency amplitude
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