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Effects of Atorvastatin on E-Selectin and Myeloperoxidase Expressions after Cerebral Ischemia-Reperfusion Injury in Rats

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Neurophysiology Aims and scope

We examined expressions of E-selectin and myeloperoxidase (MPO) in cerebral tissues after cerebral ischemia-reperfusion (CIR) in rats and evaluated neuroprotective effects of atorvastatin under these conditions. Immunohistochemical methods were used to detect E-selectin and MPO expression in the tissue. Small numbers of E-selectin- and MPO-positive cells were observed in the sham group within 4 to 24 h time intervals. In the operation group, numerous positive cells were found in the cortex and hippocampus after CIR. E-selectin expression occurred at 4 h, peaked at 12 h, and returned to nearly normal levels at 24 h. However, E-selectin expression in the intervention (CIR + atorvastatin) group was significantly lower than that in the operation group at each time (P < 0.05). Myeloperoxidase had nearly similar timing of changes in E-selectin expression, and MPO expressions at different time points in the intervention group were significantly lower than those in the operation group (P < 0.05). Therefore, expressions of E-selectin and MPO change dynamically after CIR. Atorvastatin, an agent having antiinflammatory properties, demonstrates an obvious protective effect with respect to acute CIR-related damage.

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Authors and Affiliations

  1. Department of Neurology, Second Xiangya Hospital of the Central South University, Changsha, China

    H. Cao, W. Zhong, W. Wu & X. Tang

  2. Departments of Geriatrics, Third Xiangya Hospital of the Central South University, Changsha, China

    Q. Tu

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  1. H. Cao
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  2. W. Zhong
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  3. W. Wu
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  4. Q. Tu
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  5. X. Tang
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Correspondence to X. Tang.

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Cao, H., Zhong, W., Wu, W. et al. Effects of Atorvastatin on E-Selectin and Myeloperoxidase Expressions after Cerebral Ischemia-Reperfusion Injury in Rats. Neurophysiology 46, 331–337 (2014). https://doi.org/10.1007/s11062-014-9452-3

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