, Volume 46, Issue 3, pp 247–253 | Cite as

Effects of a Saffron Alcoholic Extract on Visual Short-Term Memory in Humans: a Psychophysical Study

  • M. Ghodrat
  • H. Sahraei
  • J. Razjouyan
  • G. H. MeftahiEmail author

The effects of an extract from saffron (Crocus sativus L.) on visual short-term memory (STM) were examined in 20 volunteers. The extract was obtained from saffron petals using 100% ethylic alcohol, concentrated by vacuum evaporation, dried, and encapsulated (30 mg per capsula). Ten participants received the extract each day for three weeks, while other 10 subjects received encapsulated placebo. Then, the contrast sensitivity of a subject was estimated; sinusoidal grating patches with different contrast levels (0 – 100%) were used (experiment 1). In experiment 2, the retention of STM was assessed in two-force choice tests, using a delayed match to sample paradigm. In experiment 3, the n-back memory test with different interstimulus intervals (up to 14 sec) was used. It was found that subjects after medication with the saffron extract demonstrated better correct memorizing of the preceding visual stimuli (from two to five). At the same time, extract medication somewhat improved retention of visual STM, but only for several intermediate interstimulus intervals, and the effect was not very remarkable. Our findings emphasize the expedience to research the effects of physiologically active dietary constituents in humans.


saffron short-term memory visual memory contrast sensitivity test delayed match to a sample paradigm n-back memory test 


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  1. 1.
    J. Xu, V. D. Calhoun, G. D. Pearlson, and M. N. Potenza, “Opposite modulation of brain functional networks implicated at low vs. high demand of attention and working memory,” PLoS One, 31, No. 9 (1) (2014).Google Scholar
  2. 2.
    A. K. Barbey, M. Koenigs, and J. Grafman, “Orbitofrontal contribution to human working memory,” Cerebr. Cortex, 21, 789-795 (2011).CrossRefGoogle Scholar
  3. 3.
    R. Sala-Llonch, C. Pena-Gomez, E. M. Arenaza-Urquijo, et al., “Brain connectivity during resting state and subsequent working memory task predicts behavioural performance,” Cortex, 48, 1187-1196 (2012).PubMedCrossRefGoogle Scholar
  4. 4.
    J. R. Jonides, D. E. Lewis, C. A. Nee, et al., “The mind and brain of short-term memory,” Annu. Rev. Psychol., 59, 193-224 (2008).PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Y. Yang and N. Calakos, “Presynaptic long-term plasticity,” Front. Synapt. Neurosci., 17, No. 5, 8 (2013).Google Scholar
  6. 6.
    K. Oberauer and R. A. Kliegl, “Formal model of capacity limits in working memory,” J. Mem. Lang., 55, No. 4, 601-626 (2006).CrossRefGoogle Scholar
  7. 7.
    C. Berr, F. Portet, I. Carriere, et al., “Olive oil and cognition: results from the three-city study,” Dement. Geriat. Cogn. Disord., 28, No. 4, 357-364 (2009).CrossRefGoogle Scholar
  8. 8.
    A. Nilsson, J. Tovar, M. Johansson, et al., “A diet based on multiple functional concepts improves cognitive performance in healthy subjects,” Nutr. Metab., 15, No. 10 (1), 49 (2013).CrossRefGoogle Scholar
  9. 9.
    L. Deng, Z. N. Wu, and P. Z. Han, “Effects of different levels of food restriction on passive-avoidance memory and the expression of synapsin I in young mice,” Int. J. Neurosci., 119, No. 2, 291-304 (2009).PubMedCrossRefGoogle Scholar
  10. 10.
    T. Hashimoto and S. Watanabe, “Chronic food restriction enhances memory in mice – analysis with matched drive levels,” NeuroReport, 16, No. 10, 1129-1133 (2005).PubMedCrossRefGoogle Scholar
  11. 11.
    I. G. Newton, M. E. Forbes, C. Legault, et al., “Caloric restriction does not reverse aging-related changes in hippocampal BDNF,” Neurobiol. Aging, 26, No. 5, 683-688 (2005).PubMedCrossRefGoogle Scholar
  12. 12.
    M. C. Roberge, J. Hotte-Bernard, C. Messier, and H. Plamondon, “Food restriction attenuates ischemiainduced spatial learning and memory deficits despite extensive CA1 ischemic injury,” Behav. Brain Res., 187, No. 1, 123-132 (2008).PubMedCrossRefGoogle Scholar
  13. 13.
    S. Akhondzadeh, N. A. Tahmacebi-Pour, H. Noorbala, et al., “Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial,” Phytother. Res., 19, No. 2, 148-151 (2005).PubMedCrossRefGoogle Scholar
  14. 14.
    S. Kianbakht and A. Ghazavi, “Evaluation of immunological and hematological effects of saffron in men,” Ethnopharmacologia, 36, 78 (2005).Google Scholar
  15. 15.
    M. Liakopoulou-Kyriakides and D. A. Kyriakidis, “Croscus sativus – biological active constitutents,” Stud. Nat. Prod. Chem., 26, 293-312 (2002).CrossRefGoogle Scholar
  16. 16.
    D. H. Brainard, “The psychophysics toolbox,” Spat. Vis., 10, No. 4, 433-436.Google Scholar
  17. 17.
    M. Kleiner, D. Brainard, A. Pelli, et al., “What’s new in Psychtoolbox-3,” Perception, 36, (2007).Google Scholar
  18. 18.
    P. Harnett, D. McCarthy, and M. Davison, “Delayed signal detection, differential reinforcement and short term memory in the pigeon,” J. Exp. Anal. Behav., 42, 87-111 (1984).PubMedCentralPubMedCrossRefGoogle Scholar
  19. 19.
    D. McCarthy and P. Voss, “Delayed matching to sample performance: effects of relative reinforce frequency and of signal adverse unsigned reinforces magnitudes,” J. Exp. Anal. Behav., 63, 33-51 (1995).PubMedCentralPubMedCrossRefGoogle Scholar
  20. 20.
    W. K. Kirchner, “Age differences in short-term retention of rapidly changing information,” J. Exp. Psychol., 55, 352-358 (1958).PubMedCrossRefGoogle Scholar
  21. 21.
    M. S. Gazzaniga, “Cognitive neuroscience,” Concise Introd., 2 (2010).Google Scholar
  22. 22.
    F. J. Massey, “The Kolmogorov-Smirnov test for goodness of fit,” J. Am. Stat. Assoc., 46, No. 253, 68-78 (1951).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • M. Ghodrat
    • 1
  • H. Sahraei
    • 1
  • J. Razjouyan
    • 2
  • G. H. Meftahi
    • 1
    Email author
  1. 1.Neuroscience Research Center, Baqiyatallah (a.s.)University of Medical SciencesTehranIran
  2. 2.Electrical Engineering FacultyGarmsar Branch of the Islamic Azad UniversityGarmsarIran

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