Abstract
Results of a comparative study of the sensitivity of the system of respiratory control to increases in the CO2 concentration and the intensity of free-radical processes in young and elderly subjects are described. It is shown that normal (natural) aging is accompanied by a decrease in the sensitivity of the respiratory system to hypercapnic stimulation and a parallel significant decrease in the activity of catalase in the blood of examined subjects. Mechanisms responsible for the modifications of the sensitivity of the system of respiratory control to hypercapnia are discussed; these shifts can be at least partly related to changes in the intensity of production of free radicals observed in elderly subjects.
Similar content being viewed by others
References
D. Ballantyne and P. Scheid, “Central chemosensitivity of respiration: brief overview,” Respir. Physiol., 129, 5–12 (2001).
D. Ballantyne and P. Sheid, “Mammalian brainstem chemosensitive neurons: linking them to respiration in vitro,” J. Physiol., 525, Part 3, 567–577 (2000).
I. S. Breslav and V. D. Glebovskii, Regulation of Respiration [in Russian], Nauka, Leningrad (1981).
R. G. Kronenberg and C. W. Drage, “Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal man,” J. Clin. Invest., 52, No. 8, 1812–1819 (1973).
T. W. Chick, T. G. Cagle, F. A. Vegas, et al., “The effect or aging on submaximal exercise performance and recovery,” J. Gerontol., 46, No. 1, B34–B38 (1991).
D. K. Mulkey, R. A. Henderson III, N. A. Ritucci, et al., “Oxidative stress decreases pHi and Na+/H+ exchange and increases excitability of solitary complex neurons from rat brain slices,” Am. J. Physiol. Cell Physiol., 286, C940–C951 (2004).
D. J. C. Read, “A clinical method for assessing the ventilatory response to carbon dioxide,” Austral. Ann. Med., 16, 20–32 (1966).
T. V. Serebrovskaya and T. G. Vergulis, “On a technique of estimation of the ventilatory sensitivity in humans to hypoxia and hypercapnia,” in: Problems of Regulation of Respiration and Circulation [in Russian], Kuibyshev Med. Inst., Kuibyshev (1985), pp. 56–81.
V. B. Gavrilov, A. P. Gavrilova, and L. M. Mazhoul, “Analysis of the methods of measurements of products of lipid peroxidation in the blood serum according to the thiobarbituric acid test,” Vopr. Med. Khim., 33, No. 1, 118–122 (1987).
M. A. Korolyuk, L. I. Ivanova, and I. G. Maiorova, “A technique for measurement of the activity of catalase,” Lab. Delo, No. 1, 16–19 (1988).
T. A. Timirbulatov and S. I. Seleznev, “A technique for measurement of the intensity of free-radical oxidation of lipid-containing blood components and its diagnostic value,” Lab. Delo, No. 4, 209–211 (1988).
V. A. Kostyuk, A. I. Potapovich, and Zh. I. Kovaleva, “A simple and sensitive technique for measurement of superoxide dismutase based on the reaction of oxidation of quercetin,” Vopr. Med. Khim., No. 2, 88–91 (1990).
A. D. Bolzan, O. A. Brown, R. G. Goya, and M. S. Bianchi, “Hormonal modulation of antioxidant enzyme activities in young and old rats,” Exp. Gerontol., 30, No. 2, 169–175 (1995).
D. K. Mulkey, R. A. Henderson III, R. W. Putnam, and J. B. Dean, “Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brainstem slices,” J. Appl. Physiol., 95, 910–921 (2003).
S. Zakynthinos, P. Katsaounou, M.-H. Katarza, et al., “Antioxidants increase the ventilatory response to hyperoxic hypercapnia,” Am. J. Respir. Crit. Care Med., 175, 62–68 (2007).
H. V. Forster, P. Martino, M. Hodges, et al., “The carotid chemoreceptors are a major determinant of ventilatory CO2 sensitivity and PaCO2 during eupneic breathing,” Adv. Exp. Med. Biol., 605, 322–326 (2008).
A. C. Takakura, T. S. Moreira, E. Colombari, et al., “Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats,” J. Physiol., 752, Part 2, 503–523 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
Neirofiziologiya/Neurophysiology, Vol. 40, No. 1, pp. 53–57, January–February, 2008.
Rights and permissions
About this article
Cite this article
Kolesnikova, E.É. Aging-related changes in the sensitivity of the system of respiratory control and the intensity of free-radical processes in humans. Neurophysiology 40, 48–52 (2008). https://doi.org/10.1007/s11062-008-9017-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11062-008-9017-4